NME5 - NME/NM23 family member 5 Gene

Also Known as CILD48; NM23H5; RSPH23; NM23-H5

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8382

About NME5

Cytogenetic location: 5q31.2 Genomic coordinates (GRCh38): 5:138,115,175-138,139,428 (from NCBI)

This gene has 6 transcripts (splice variants), 199 orthologues and 8 paralogues. Biased expression in testis (RPKM 15.2), kidney (RPKM 4.4) and 8 other tissues.

Summary

Predicted to enable nucleoside diphosphate kinase activity. Predicted to be involved in negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway and spermatid development. Predicted to act upstream of or within cilium assembly; epithelial cilium movement involved in extracellular fluid movement; and ventricular system development. Predicted to be located in cilium. [provided by Alliance of Genome Resources, Apr 2022]

NME5 Products (1)

mRNA Protein Name
NM_003551.3 NP_003542.1 nucleoside diphosphate kinase homolog 5

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables 3'-5' exonuclease activity IDA
IDA: Inferred from direct assay
16313181 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Biological Process GO Annotation Evidence References Source
involved in spermatid development IMP
IMP: Inferred from mutant phenotype
32185794 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NME5 Protein Structure

NDK

NDK: Nucleoside diphosphate kinase (13 - 145)

Dpy-30

Dpy-30: Dpy-30 motif (157 - 197)

  • 0
  • 100
  • 200
  • 212 a.a.
Protein Preferred Names Protein Names

nucleoside diphosphate kinase homolog 5

  • IPIA-beta

NME5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NME5 P56597 JPH3 Homo sapiens Q8WXH2
Y2H Array
32814053
Intra
NME5 P56597 JPH3 Homo sapiens Q8WXH2
Validated Y2H
32814053
Intra
NME5 P56597 JPH3 Homo sapiens Q8WXH2
Y2H Pooling
32814053
Intra
NME5 P56597 DYDC1 Homo sapiens Q8WWB3
Y2H Array
32296183
Intra
NME5 P56597 DYDC1 Homo sapiens Q8WWB3
Y2H Pooling
16189514
Intra
NME5 P56597 DYDC1 Homo sapiens Q8WWB3
Y2H Prey Pooling
32296183
Intra
NME5 P56597 DYDC1 Homo sapiens Q8WWB3
Y2H Prey Pooling
25416956
Intra
NME5 P56597 DYDC1 Homo sapiens Q8WWB3
Validated Y2H
25416956
Intra
NME5 P56597 DYDC1 Homo sapiens Q8WWB3
Validated Y2H
32296183
Intra
NME5 P56597 DYDC1 Homo sapiens Q8WWB3
Y2H Array
25416956
Intra
NME5 P56597 DYDC2 Homo sapiens Q96IM9
Y2H Pooling
16189514
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Ciliary Dyskinesia, Primary, 48, Without Situs Inversus

  • CILD48
Primary Ciliary Dyskinesia

  • Immotile Cilia Syndrome

  • Kartagener Syndrome

  • Dextrocardia Bronchiectasis And Sinusitis

  • Pcd

  • Ciliary Motility Disorders

  • Ciliary Motility Disorder

  • Immotile Ciliary Syndrome

  • Ciliary Dyskinesia Primary

  • Ics

  • Polynesian Bronchiectasis

  • Dextrocardia-Bronchiectasis-Sinusitis Syndrome

  • Immotile Cilia Syndrome, Kartagener Type

  • Primary Ciliary Dyskinesia And Situs Inversus

  • Primary Ciliary Dyskinesia, Kartagener Type

  • Siewert Syndrome

  • Dyskinesia, Ciliary, Primary
Visceral Heterotaxy

  • Situs Ambiguus

  • Heterotaxia

  • Heterotaxy Syndrome

  • Heterotaxy

  • Lateralization Defect

  • Situs Ambiguous

  • Left Isomerism

  • Htx

  • Ivemark Syndrome

  • Right Isomerism

  • Situs Ambiguus Viscerum

  • Incomplete Situs Inversus

  • Partial Situs Inversus

  • Heterotaxy, Visceral

  • Asplenia Syndrome

  • Bilateral Left-Sidedness

  • Polysplenia Syndrome

  • Moller Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09376 NME5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22261 Nme5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28783 Nme5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus NME5 MGD MGI:1922783
Macaca mulatta NME5 VGNC VGNC:84453
Felis catus NME5 VGNC VGNC:68504
Rattus norvegicus NME5 RGD RGD:1583004
Bos taurus NME5 VGNC VGNC:32127
Others NME5 NCBI