Bcl2l12 - BCL2-like 12 (proline rich) Gene

Also Known as Bcl-L12; Bcl2-L12; 2810475P17Rik; 5430429M05Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 75736

Summary

Enables p53 binding activity. Acts upstream of or within negative regulation of cellular senescence and negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator. Predicted to be located in nucleus. Is expressed in several structures, including adrenal gland; genitourinary system; gut; quadriceps femoris muscle; and respiratory system. Orthologous to human BCL2L12 (BCL2 like 12). [provided by Alliance of Genome Resources, Apr 2022]

Bcl2l12 Products (4)

mRNA Protein Name
NM_001403495.1 NP_001390424.1 bcl-2-like protein 12 isoform a
NM_001403496.1 NP_001390425.1 bcl-2-like protein 12 isoform a
NM_001403497.1 NP_001390426.1 bcl-2-like protein 12 isoform b
NM_029410.4 NP_083686.1 bcl-2-like protein 12 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables p53 binding IPI
IPI: Inferred from physical interaction
20837658 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of cellular senescence IDA
IDA: Inferred from direct assay
20837658 MGI
acts upstream of or within negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IDA
IDA: Inferred from direct assay
20837658 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

bcl-2-like protein 12

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-149622 Bcl-2-IN-12 Inhibitor / Unkown
HY-RS01430 BCL2L12 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21989 Bcl2l12 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28507 Bcl2l12 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bcl2l12 NCBI NCBI:83596