BCL2L12 - BCL2 like 12 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 83596

About BCL2L12

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:49,665,142-49,673,916 (from NCBI)

This gene has 19 transcripts (splice variants), 153 orthologues, 1 paralogue and is associated with 49 phenotypes. Ubiquitous expression in lymph node (RPKM 7.1), spleen (RPKM 6.8) and 25 other tissues.

Summary

This gene encodes a member of a family of proteins containing a Bcl-2 homology domain 2 (BH2). The encoded protein is an anti-apoptotic factor that acts as an inhibitor of caspases 3 and 7 in the cytoplasm. In the nucleus, it binds to the p53 tumor suppressor protein, preventing its association with target genes. Overexpression of this gene has been detected in a number of different cancers. There is a pseudogene for this gene on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

BCL2L12 Products (8)

mRNA	Protein	Name
NM_001040668.2	NP_001035758.2	bcl-2-like protein 12 isoform 3
NM_001282516.2	NP_001269445.2	bcl-2-like protein 12 isoform 4
NM_001282517.2	NP_001269446.2	bcl-2-like protein 12 isoform 2
NM_001282519.2	NP_001269448.2	bcl-2-like protein 12 isoform 5
NM_001282520.1	NP_001269449.1	bcl-2-like protein 12 isoform 6
NM_001282521.2	NP_001269450.2	bcl-2-like protein 12 isoform 7
NM_001385706.1	NP_001372635.1	bcl-2-like protein 12 isoform 8
NM_138639.2	NP_619580.2	bcl-2-like protein 12 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19376117	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in inhibition of cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: Inferred from direct assay	22262180	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	22262180	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	20837658	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
bcl-2-like protein 12	BCL2-like 12 (proline rich)

BCL2L12 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	BCL2L12	Q9HB09	BAX	Homo sapiens	Q07812	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant BCL2L12 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76165	BCL2L12 Protein, Human (GST)	Q9HB09-1 (P64-K143)	≥ 95%, as determined by reducing SDS-PAGE.

BCL2L12 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82648	BPR Antibody (YA2393)	WB, IHC-P, ICC/IF, IP, FC	Human

Related Diseases

Diseases	Alias
Skin Squamous Cell Carcinoma	Squamous Cell Carcinoma Of Skin Epidermoid Skin Carcinoma Squamous Cell Carcinoma Of The Skin Squamous Cell Epithelioma Of Skin Cutaneous Squamous Cell Carcinoma Scc - [Squamous Cell Carcinoma] Of Skin
Skin Melanoma	Cutaneous Melanoma Malignant Ear Melanoma Malignant Lip Melanoma Malignant Lower Limb Melanoma Malignant Melanoma Of Ear And/Or External Auricular Canal Malignant Melanoma Of Skin Of Lower Limb Malignant Melanoma Of Skin Of Trunk Except Scrotum Malignant Melanoma Of Skin Of Upper Limb Malignant Neck Melanoma Malignant Scalp Melanoma Malignant Trunk Melanoma Malignant Upper Limb Melanoma Melanoma, Cutaneous Malignant Melanoma Malignant Melanoma Of Skin Melanoma Nos Malignant Mole, Meaning Melanoma Of Unspecified Site Melanoma Of Unspecified Site Cutaneous Malignant Melanoma Mm - [Malignant Melanoma]
Autoimmune Lymphoproliferative Syndrome, Type Iii	ALPS3 Autoimmune Lymphoproliferative Syndrome Type 3 Immunodeficiency, Common Variable, 9, Formerly Cvid9, Formerly Autoimmune Lymphoproliferative Syndrome Type Iii Autoimmune Lymphoproliferative Syndrome 3 Cvid9 Immunodeficiency, Common Variable, 9 Type 3 Autoimmune Lymphoproliferative Syndrome Immunodeficiency, Variable, Common, Type 9
Laryngeal Benign Neoplasm	Laryngeal Tumor Larynx Neoplasm Neoplasm Of Larynx Laryngeal Cancer Laryngeal Carcinoma Cancer Of Larynx
Gliosarcoma	Glioblastoma With Sarcomatous Component Sarcomatous Glioblastoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-149622	Bcl-2-IN-12	Inhibitor	/	Unkown
HY-RS01430	BCL2L12 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21989	Bcl2l12 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28507	Bcl2l12 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	BCL2L12	MGD	MGI:1922986
Rattus norvegicus	BCL2L12	RGD	RGD:1307361
Bos taurus	BCL2L12	VGNC	VGNC:26447
Macaca mulatta	BCL2L12	VGNC	VGNC:103792
Canis familiaris	BCL2L12	VGNC	VGNC:53525
Others	BCL2L12	NCBI