Brsk2 - BR serine/threonine kinase 2 Gene

Also Known as SADA; SAD-A; 4833424K13Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 75770

Summary

Enables protein kinase binding activity; protein serine/threonine kinase activity; and tau-protein kinase activity. Involved in several processes, including microtubule Cytoskeleton organization involved in establishment of planar polarity; regulation of axonogenesis; and regulation of Insulin secretion involved in cellular response to glucose stimulus. Acts upstream of or within neuron projection morphogenesis and peptidyl-serine phosphorylation. Predicted to be located in distal axon and endoplasmic reticulum. Predicted to be active in centrosome and cytoplasm. Is expressed in several structures, including central nervous system and retina. Orthologous to human BRSK2 (BR serine/threonine kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Brsk2 Products (4)

mRNA	Protein	Name
NM_001009929.3	NP_001009929.1	serine/threonine-protein kinase BRSK2 isoform beta
NM_001009930.3	NP_001009930.1	serine/threonine-protein kinase BRSK2 isoform gamma
NM_001276763.1	NP_001263692.1	serine/threonine-protein kinase BRSK2 isoform delta
NM_029426.2	NP_083702.1	serine/threonine-protein kinase BRSK2 isoform alpha

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20026642	MGI
enables protein kinase binding	IPI IPI: Inferred from physical interaction	17482548	MGI
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	15705853	MGI
enables tau-protein kinase activity	IDA IDA: Inferred from direct assay	15705853	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in axonogenesis	IMP IMP: Inferred from mutant phenotype	17482548	MGI
acts upstream of or within establishment of cell polarity	IGI IGI: Inferred from genetic interaction	15705853	MGI
involved in establishment of cell polarity	IGI IGI: Inferred from genetic interaction	15705853	MGI
involved in establishment of cell polarity	IMP IMP: Inferred from mutant phenotype	17482548	MGI
involved in microtubule cytoskeleton organization involved in establishment of planar polarity	IGI IGI: Inferred from genetic interaction	18268107	MGI
acts upstream of or within neuron differentiation	IGI IGI: Inferred from genetic interaction	15705853	MGI
involved in neuron differentiation	IGI IGI: Inferred from genetic interaction	15705853	MGI
acts upstream of or within neuron projection morphogenesis	IGI IGI: Inferred from genetic interaction	20026642	MGI
acts upstream of or within peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	20026642	MGI
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	15705853	MGI
involved in regulation of axonogenesis	IGI IGI: Inferred from genetic interaction	18268107	MGI
involved in regulation of insulin secretion involved in cellular response to glucose stimulus	IMP IMP: Inferred from mutant phenotype	22798068	MGI
involved in regulation of neuron projection development	IGI IGI: Inferred from genetic interaction	18268107	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
serine/threonine-protein kinase BRSK2	BR serine/threonine-protein kinase 2 brain-specific serine/threonine-protein kinase 2 serine/threonine-protein kinase SAD-A

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS23792	Brsk2 Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Brsk2	NCBI	NCBI:9024