BRSK2
BRSK2, also named SAD-A, is the second brain-enriched AMPK-related kinase, activated by LKB1 phosphorylation and cooperating with BRSK1 in neuronal development. It is additionally expressed in pancreatic islets, where functional studies implicate it in insulin granule exocytosis and glucose-stimulated insulin secretion. Like BRSK1, BRSK2 phosphorylates tau and microtubule-associated proteins, influencing cytoskeletal dynamics, and the two kinases act redundantly in many contexts, with combined loss causing severe defects in axon specification and synapse formation. Its catalytic domain is highly similar to BRSK1, yet the distinct tissue distribution suggests specialized endocrine roles beyond the brain, distinguishing BRSK2 from its purely neuronal sibling.
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BRSK2 Protéines Recombinantes (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formule: Human
- Masse moléculaire: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
