BRSK2 Protein, Human (Active, sf9, His-GST)

BRSK2 Protein serves as a serine/threonine-protein kinase with multifaceted roles in the regulation of cellular processes. It is a key player in the polarization of neurons and axonogenesis, as well as cell cycle progression and insulin secretion. Upon phosphorylation and activation by STK11/LKB1, BRSK2 assumes a crucial role in orchestrating the polarization of cortical neurons, potentially through phosphorylation of microtubule-associated proteins, including MAPT/TAU at 'Thr-529' and 'Ser-579.' Additionally, BRSK2 influences neuron polarization by mediating the phosphorylation of WEE1 at 'Ser-642,' down-regulating WEE1 activity in polarized neurons. The kinase is integral to the regulation of mitotic cell cycle progression and the onset of mitosis. Its involvement in insulin secretion, responsive to elevated glucose levels, is noteworthy, with distinct phosphorylation sites at Thr-174 and Thr-260 exhibiting differential effects on insulin secretion. Beyond these functions, BRSK2 plays a role in actin cytoskeleton reorganization and may contribute to the apoptotic response triggered by endoplasmic reticulum (ER) stress.