Nt5c2 - 5'-nucleotidase, cytosolic II Gene

Also Known as Gmp; CnII; Nt5b; Pnt5; cN-II; Gm9751; 2010002I23Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 76952

Summary

Enables GMP 5'-nucleotidase activity. Involved in GMP catabolic process to guanine; allantoin metabolic process; and dGMP catabolic process. Located in cytosol. Is expressed in several structures, including alimentary system; integumental system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 45. Orthologous to human NT5C2 (5'-nucleotidase, cytosolic II). [provided by Alliance of Genome Resources, Apr 2022]

Nt5c2 Products (7)

mRNA Protein Name
NM_001164363.2 NP_001157835.1 cytosolic purine 5'-nucleotidase isoform 1
NM_001164365.2 NP_001157837.1 cytosolic purine 5'-nucleotidase isoform 2
NM_001377066.1 NP_001363995.1 cytosolic purine 5'-nucleotidase isoform 3
NM_001377068.1 NP_001363997.1 cytosolic purine 5'-nucleotidase isoform 3
NM_001377069.1 NP_001363998.1 cytosolic purine 5'-nucleotidase isoform 3
NM_001377070.1 NP_001363999.1 cytosolic purine 5'-nucleotidase isoform 4
NM_029810.5 NP_084086.3 cytosolic purine 5'-nucleotidase isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GMP 5'-nucleotidase activity IDA
IDA: Inferred from direct assay
5560407 MGI
Biological Process GO Annotation Evidence References Source
involved in GMP catabolic process IDA
IDA: Inferred from direct assay
5560407 MGI
involved in GMP catabolic process to guanine IDA
IDA: Inferred from direct assay
5560407 MGI
involved in allantoin metabolic process IDA
IDA: Inferred from direct assay
5560407 MGI
involved in amide catabolic process IDA
IDA: Inferred from direct assay
5560407 MGI
involved in dGMP catabolic process IDA
IDA: Inferred from direct assay
5560407 MGI
Cellular Component GO Annotation Evidence References Source
is active in cytosol IDA
IDA: Inferred from direct assay
11690631 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cytosolic purine 5'-nucleotidase

  • cytosolic 5'-nucleotidase II

  • cytosolic nucleoside phosphotransferase 5'N

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-167710 CRCD2 99.02% Unkown
HY-RS09609 NT5C2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21673 Nt5c2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28191 Nt5c2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nt5c2 NCBI NCBI:22978