2. Gene
  3. PTP4A1 - protein tyrosine phosphatase 4A1 Gene

PTP4A1 - protein tyrosine phosphatase 4A1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HH72; PRL1; PRL-1; PTPCAAX1; PTP(CAAX1)

Gene ID: 7803 | Gene type: protein coding

About PTP4A1

Cytogenetic location: 6q12 Genomic coordinates (GRCh38): 6:63,516,440-63,583,588 (from NCBI)

This gene has 8 transcripts (splice variants), 210 orthologues and 8 paralogues. Broad expression in liver (RPKM 141.5), adrenal (RPKM 72.5) and 24 other tissues.

Summary

This gene encodes a member of a small class of prenylated Protein tyrosine phosphatases (PTPs), which contain a PTP domain and a characteristic C-terminal prenylation motif. The encoded protein is a cell signaling molecule that plays regulatory roles in a variety of cellular processes, including cell proliferation and migration. The protein may also be involved in Cancer development and metastasis. This tyrosine Phosphatase is a nuclear protein, but may associate with plasma membrane by means of its prenylation motif. Pseudogenes related to this gene are located on chromosomes 1, 2, 5, 7, 11 and X. [provided by RefSeq, Jun 2013]

PTP4A1 Products(14)

mRNA Protein Name
NM_001385254.1 NP_001372183.1 protein tyrosine phosphatase type IVA 1 isoform 1
NM_001385255.1 NP_001372184.1 protein tyrosine phosphatase type IVA 1 isoform 1
NM_001385256.1 NP_001372185.1 protein tyrosine phosphatase type IVA 1 isoform 1
NM_001385257.1 NP_001372186.1 protein tyrosine phosphatase type IVA 1 isoform 1
NM_001385258.1 NP_001372187.1 protein tyrosine phosphatase type IVA 1 isoform 1
NM_001385259.1 NP_001372188.1 protein tyrosine phosphatase type IVA 1 isoform 1
NM_001385260.1 NP_001372189.1 protein tyrosine phosphatase type IVA 1 isoform 1
NM_001385262.2 NP_001372191.1 protein tyrosine phosphatase type IVA 1 isoform 1
NM_001385263.2 NP_001372192.1 protein tyrosine phosphatase type IVA 1 isoform 2
NM_001385265.1 NP_001372194.1 protein tyrosine phosphatase type IVA 1 isoform 3
NM_001385266.1 NP_001372195.1 protein tyrosine phosphatase type IVA 1 isoform 4
NM_001385267.2 NP_001372196.1 protein tyrosine phosphatase type IVA 1 isoform 1
NM_001385268.2 NP_001372197.1 protein tyrosine phosphatase type IVA 1 isoform 5
NM_003463.5 NP_003454.1 protein tyrosine phosphatase type IVA 1 isoform 1

PTP4A1 Protein Structure

DSPc

DSPc: Dual specificity phosphatase, catalytic domain (34 - 142)

  • 0
  • 100
  • 173 a.a.
Protein Preferred Names Protein Names

protein tyrosine phosphatase type IVA 1

PVT1/PTP4A1 fusion

Recombinant PTP4A1 Proteins

Cat. No. Product Name Accession Purity
HY-P701032 PTP4A1 Protein, Human (His) Q93096 (M1-C170) ≥95%

Related Diseases

Diseases Alias
Ovarian Lymphoma
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-135457 JMS-053 ≥98.0% Unkown
HY-RS11409 PTP4A1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus PTP4A1 VGNC VGNC:33523
Mus musculus PTP4A1 MGD MGI:1277096
Macaca mulatta PTP4A1 VGNC VGNC:83452
Felis catus PTP4A1 VGNC VGNC:97575
Rattus norvegicus PTP4A1 RGD RGD:61970
Others PTP4A1 NCBI