PTP4A1 - protein tyrosine phosphatase 4A1 Gene

Also Known as HH72; PRL1; PRL-1; PTPCAAX1; PTP(CAAX1)

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7803

About PTP4A1

Cytogenetic location: 6q12 Genomic coordinates (GRCh38): 6:63,516,440-63,583,588 (from NCBI)

This gene has 8 transcripts (splice variants), 210 orthologues and 8 paralogues. Broad expression in liver (RPKM 141.5), adrenal (RPKM 72.5) and 24 other tissues.

Summary

This gene encodes a member of a small class of prenylated Protein tyrosine phosphatases (PTPs), which contain a PTP domain and a characteristic C-terminal prenylation motif. The encoded protein is a cell signaling molecule that plays regulatory roles in a variety of cellular processes, including cell proliferation and migration. The protein may also be involved in Cancer development and metastasis. This tyrosine Phosphatase is a nuclear protein, but may associate with plasma membrane by means of its prenylation motif. Pseudogenes related to this gene are located on chromosomes 1, 2, 5, 7, 11 and X. [provided by RefSeq, Jun 2013]

PTP4A1 Products (14)

mRNA Protein Name
NM_001385254.1 NP_001372183.1 protein tyrosine phosphatase type IVA 1 isoform 1
NM_001385255.1 NP_001372184.1 protein tyrosine phosphatase type IVA 1 isoform 1
NM_001385256.1 NP_001372185.1 protein tyrosine phosphatase type IVA 1 isoform 1
NM_001385257.1 NP_001372186.1 protein tyrosine phosphatase type IVA 1 isoform 1
NM_001385258.1 NP_001372187.1 protein tyrosine phosphatase type IVA 1 isoform 1
NM_001385259.1 NP_001372188.1 protein tyrosine phosphatase type IVA 1 isoform 1
NM_001385260.1 NP_001372189.1 protein tyrosine phosphatase type IVA 1 isoform 1
NM_001385262.2 NP_001372191.1 protein tyrosine phosphatase type IVA 1 isoform 1
NM_001385263.2 NP_001372192.1 protein tyrosine phosphatase type IVA 1 isoform 2
NM_001385265.1 NP_001372194.1 protein tyrosine phosphatase type IVA 1 isoform 3
NM_001385266.1 NP_001372195.1 protein tyrosine phosphatase type IVA 1 isoform 4
NM_001385267.2 NP_001372196.1 protein tyrosine phosphatase type IVA 1 isoform 1
NM_001385268.2 NP_001372197.1 protein tyrosine phosphatase type IVA 1 isoform 5
NM_003463.5 NP_003454.1 protein tyrosine phosphatase type IVA 1 isoform 1

PTP4A1 Protein Structure

DSPc

DSPc: Dual specificity phosphatase, catalytic domain (34 - 142)

  • 0
  • 100
  • 173 a.a.
Protein Preferred Names Protein Names

protein tyrosine phosphatase type IVA 1

  • PVT1/PTP4A1 fusion

PTP4A1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PTP4A1 Q93096 CNNM1 Homo sapiens Q9NRU3
Validated Y2H
32296183
Intra
PTP4A1 Q93096 CNNM1 Homo sapiens Q9NRU3
Pull Down
28330616
Intra
PTP4A1 Q93096 CNNM1 Homo sapiens Q9NRU3
Y2H Array
32296183
Intra
PTP4A1 Q93096 CNNM1 Homo sapiens Q9NRU3
Anti Tag CoIP
33961781
Intra
PTP4A1 Q93096 CNNM1 Homo sapiens Q9NRU3
Anti Tag CoIP
27880917
Intra
PTP4A1 Q93096 CNNM1 Homo sapiens Q9NRU3
Y2H Prey Pooling
32296183
Intra
PTP4A1 Q93096 CNNM1 Homo sapiens Q9NRU3
BioID
28330616
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PTP4A1 Proteins

Cat. No. Product Name Accession Purity
HY-P701032 PTP4A1 Protein, Human (His) Q93096 (M1-C170) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Ovarian Lymphoma
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-135457 JMS-053 Inhibitor 98.0% Unkown
HY-183953 JMS-038 Inhibitor / Unkown
HY-RS11409 PTP4A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19806 Ptp4a1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26302 Ptp4a1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus PTP4A1 VGNC VGNC:33523
Mus musculus PTP4A1 MGD MGI:1277096
Macaca mulatta PTP4A1 VGNC VGNC:83452
Felis catus PTP4A1 VGNC VGNC:97575
Rattus norvegicus PTP4A1 RGD RGD:61970
Others PTP4A1 NCBI