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CNNM1 - cyclin and CBS domain divalent metal cation transport mediator 1 Gene

Also Known as ACDP1; CLP-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 26507

About CNNM1

Cytogenetic location: 10q24.2 Genomic coordinates (GRCh38): 10:99,329,356-99,394,330 (from NCBI)

This gene has 3 transcripts (splice variants), 262 orthologues and 3 paralogues. Biased expression in testis (RPKM 7.0), brain (RPKM 4.2) and 7 other tissues.

Summary

This gene encodes a member of the ancient conserved domain protein family. The encoded protein may bind copper. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]

CNNM1 Products (4)

mRNA	Protein	Name
NM_001345887.2	NP_001332816.1	metal transporter CNNM1 isoform 2
NM_001345888.2	NP_001332817.1	metal transporter CNNM1 isoform 3
NM_001345889.2	NP_001332818.1	metal transporter CNNM1 isoform 4
NM_020348.3	NP_065081.2	metal transporter CNNM1 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	27880917	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CNNM1 Protein Structure

DUF21

CBS

0
200
400
600
800
951 a.a.

Protein Preferred Names	Protein Names
metal transporter CNNM1	ancient conserved domain-containing protein 1

CNNM1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CNNM1	Q9NRU3	PTP4A2	Homo sapiens	Q12974	Y2H Prey Pooling	32296183
Intra	CNNM1	Q9NRU3	PTP4A2	Homo sapiens	Q12974	Y2H Array	32296183
Intra	CNNM1	Q9NRU3	HSF2BP	Homo sapiens	O75031	Y2H Array	32296183
Intra	CNNM1	Q9NRU3	HSF2BP	Homo sapiens	O75031	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Jalili Syndrome	Cone-Rod Dystrophy And Amelogenesis Imperfecta Cone Rod Dystrophy-Amelogenesis Imperfecta Syndrome Cone-Rod Dystrophy Amelogenesis Imperfecta Cone-Rod Dystrophy With Amelogenesis Imperfecta JALIS Cone Rod Dystrophy Amelogenesis Imperfecta
Urofacial Syndrome 1	Urofacial Syndrome Ochoa Syndrome Hydronephrosis With Peculiar Facial Expression Ufs Inverted Smile And Occult Neuropathic Bladder Partial Facial Palsy With Urinary Abnormalities UFS1 Urofacial Ochoa'S Syndrome Urofacial Syndrome Type 1 Facial Palsy, Partial, With Urinary Abnormalities Hydronephrosis-Inverted Smile Inverted Smile-Neurogenic Bladder Hydronephrosis-Inverted Smile Syndrome Inverted Smile-Neurogenic Bladder Syndrome Partial Facial Palsy Partial With Urinary Abnormalities Urologic Diseases
Primary Hypomagnesemia	Familial Primary Hypomagnesemia Homg Primary Familial Hypomagnesemia Genetic Primary Hypomagnesemia Hypomagnesemia 1, Intestinal
Cone-Rod Dystrophy 2	Cone-Rod Dystrophy CORD2 Cone-Rod Retinal Dystrophy Rcrd2 Cone-Rod Retinal Dystrophy 2 Crd2 Cord Crd Retinal Cone-Rod Dystrophy Cone-Rod Retinal Dystrophy-2 Retinal Cone-Rod Dystrophy 2 Tapetoretinal Degeneration Cone-Rod Degeneration Cone Rod Dystrophy Dystrophy, Cone-Rod Dystrophy, Cone-Rod, Type 2 Retinitis Pigmentosa Retinitis Pigmentosa 2 Progressive Cone-Rod Dystrophy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02895	CNNM1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21534	Cnnm1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28052	Cnnm1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CNNM1	MGD	MGI:1891366
Macaca mulatta	CNNM1	VGNC	VGNC:103799
Felis catus	CNNM1	VGNC	VGNC:61023
Rattus norvegicus	CNNM1	RGD	RGD:1308728
Bos taurus	CNNM1	VGNC	VGNC:27510
Canis familiaris	CNNM1	VGNC	VGNC:39406
Others	CNNM1	NCBI