Dlst - dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) Gene

Also Known as DLTS; 1600017E01Rik; 4632413C10Rik; 4930529O08Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 78920

Summary

Predicted to enable chaperone binding activity; dihydrolipoyllysine-residue succinyltransferase activity; and heat shock protein binding activity. Predicted to be involved in several processes, including 2-oxoglutarate metabolic process; histone succinylation; and tricarboxylic acid cycle. Located in mitochondrion and myelin sheath. Is expressed in several structures, including alimentary system; metanephros; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease and paraganglioma. Orthologous to human DLST (dihydrolipoamide S-succinyltransferase). [provided by Alliance of Genome Resources, Apr 2022]

Dlst Products (1)

mRNA Protein Name
NM_030225.4 NP_084501.1 dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
29128334 MGI
Cellular Component GO Annotation Evidence References Source
part of oxoglutarate dehydrogenase complex IMP
IMP: Inferred from mutant phenotype
22169199 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

  • 2-oxoglutarate dehydrogenase complex component E2

  • E2K

  • OGDC-E2

  • dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex

Dlst Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Dlst Q9D2G2 Plec Mus musculus Q9QXS1
Anti Bait CoIP
29128334
Intra
Dlst Q9D2G2 Plec Mus musculus Q9QXS1
Crosslink
29128334
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03811 DLST Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18924 Dlst Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25414 Dlst Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dlst NCBI NCBI:1743