Prkaa2 - protein kinase AMP-activated catalytic subunit alpha 2 Gene

Also Known as Ampk; Ampka2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 78975

Summary

Enables AMP-activated protein kinase activity; ATP binding activity; and protein-macromolecule adaptor activity. Involved in several processes, including energy homeostasis; fatty acid homeostasis; and positive regulation of glycolytic process. Located in several cellular components, including apical plasma membrane; dendrite; and neuronal cell body. Part of nucleotide-activated protein kinase complex. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human PRKAA2 (protein kinase AMP-activated catalytic subunit alpha 2). [provided by Alliance of Genome Resources, Apr 2022]

Prkaa2 Products (1)

mRNA Protein Name
NM_023991.1 NP_076481.1 5'-AMP-activated protein kinase catalytic subunit alpha-2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables AMP-activated protein kinase activity IDA
IDA: Inferred from direct assay
11069105 RGD
enables AMP-activated protein kinase activity IMP
IMP: Inferred from mutant phenotype
8955377 RGD
enables ATP binding IDA
IDA: Inferred from direct assay
16648175 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
11069105 RGD
enables protein kinase activity IDA
IDA: Inferred from direct assay
12065578 RGD
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
8955377 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
14511394 RGD
enables protein-macromolecule adaptor activity IDA
IDA: Inferred from direct assay
15695819 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to calcium ion IMP
IMP: Inferred from mutant phenotype
25788287 RGD
involved in cellular response to glucose stimulus IMP
IMP: Inferred from mutant phenotype
25788287 RGD
involved in energy homeostasis IDA
IDA: Inferred from direct assay
11724780 RGD
involved in fatty acid homeostasis IDA
IDA: Inferred from direct assay
11724780 RGD
involved in positive regulation of glycolytic process IDA
IDA: Inferred from direct assay
11069105 RGD
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
8955377 RGD
involved in regulation of lipid metabolic process IDA
IDA: Inferred from direct assay
12065578 RGD
involved in response to activity IDA
IDA: Inferred from direct assay
17253964 RGD
involved in response to caffeine IDA
IDA: Inferred from direct assay
19608206 RGD
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
18256313 RGD
located in axon IMP
IMP: Inferred from mutant phenotype
25788287 RGD
located in cytoplasm IDA
IDA: Inferred from direct assay
18256313 RGD
located in dendrite IMP
IMP: Inferred from mutant phenotype
25788287 RGD
located in neuronal cell body IMP
IMP: Inferred from mutant phenotype
25788287 RGD
part of nucleotide-activated protein kinase complex IDA
IDA: Inferred from direct assay
16648175 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
14511394 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

5'-AMP-activated protein kinase catalytic subunit alpha-2

  • ACACA kinase

  • AMP-activated protein kinase

  • AMPK alpha-2 chain

  • AMPK subunit alpha-2

  • HMGCR kinase

  • acetyl-CoA carboxylase kinase

  • hydroxymethylglutaryl-CoA reductase kinase

  • protein kinase, AMP-activated, alpha 2 catalytic subunit

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P11779 Ac-RKAA-PABC-MMAE Inhibitor / Unkown
HY-P11779A Ac-RKAA-PABC-MMAE TFA Inhibitor / Unkown
HY-RS21177 Prkaa2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11101 PRKAA2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27694 Prkaa2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Prkaa2 NCBI NCBI:5563