CRELD2 - cysteine rich with EGF like domains 2 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79174

About CRELD2

Cytogenetic location: 22q13.33 Genomic coordinates (GRCh38): 22:49,918,634-49,927,537 (from NCBI)

This gene has 11 transcripts (splice variants), 205 orthologues and 8 paralogues. Ubiquitous expression in thyroid (RPKM 19.3), testis (RPKM 9.9) and 25 other tissues.

Summary

Predicted to enable calcium ion binding activity and protein disulfide isomerase activity. Predicted to be located in Golgi apparatus; endoplasmic reticulum; and extracellular space. [provided by Alliance of Genome Resources, Apr 2022]

CRELD2 Products (4)

mRNA Protein Name
NM_001135101.3 NP_001128573.1 protein disulfide isomerase CRELD2 isoform a precursor
NM_001284317.2 NP_001271246.1 protein disulfide isomerase CRELD2 isoform c precursor
NM_001284318.2 NP_001271247.1 protein disulfide isomerase CRELD2 isoform d precursor
NM_024324.5 NP_077300.3 protein disulfide isomerase CRELD2 isoform b precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16238698 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CRELD2 Protein Structure

DUF3456

DUF3456: TLR4 regulator and MIR-interacting MSAP (30 - 86)

DUF3456

DUF3456: TLR4 regulator and MIR-interacting MSAP (88 - 128)

EGF_CA

EGF_CA: Calcium-binding EGF domain (290 - 330)

  • 0
  • 100
  • 200
  • 300
  • 353 a.a.
Protein Preferred Names Protein Names

protein disulfide isomerase CRELD2

  • cysteine-rich with EGF-like domain protein 2

Recombinant CRELD2 Proteins

Cat. No. Product Name Accession Purity
HY-P70081 CRELD2 Protein, Human (HEK293, His) Q6UXH1-2 (A25-L321) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P700637 CRELD2 Protein, Human (329a.a, HEK293, His) Q6UXH1-1 (A25-L353) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Spondyloperipheral Dysplasia

  • Spondyloperipheral Dysplasia With Short Ulna

  • Spondyloperipheral Dysplasia-Short Ulna Syndrome

  • SPD

  • Dysplasia, Spondyloperipheral

  • Spondyloperipheral Dysplasia Short Ulna
Epiphyseal Dysplasia, Multiple, 5

  • EDM5

  • Multiple Epiphyseal Dysplasia 5

  • Bhmed

  • Multiple Epiphyseal Dysplasia Type 5

  • Multiple Epiphyseal Dysplasia, Matn3-Related

  • Microepiphyseal Dysplasia, Bilateral Hereditary

  • Bilateral Hereditary Microepiphyseal Dysplasia

  • Multiple Epiphyseal Dysplasia Matn3-Related

  • Epiphyseal Dysplasia Multiple 5

  • Multiple Epiphyseal Dysplasia, Matn3 Related

  • Bilateral Hereditary Micro-Epiphyseal Dysplasia

  • Med5

  • Polyepiphyseal Dysplasia Type 5

  • Dysplasia, Epiphyseal, Multiple, Type 5
Multiple Epiphyseal Dysplasia

  • Med

  • Polyepiphyseal Dysplasia

  • Edm

  • Epiphyseal Dysplasia, Multiple, 1

  • Epiphyseal Dysplasia, Multiple, 2

  • Epiphyseal Dysplasia, Multiple, 3

  • Epiphyseal Dysplasia, Multiple, 4

  • Epiphyseal Dysplasia, Multiple, 5

  • Epiphyseal Dysplasia, Multiple

  • Edm1

  • Edm2

  • Edm3

  • Edm4

  • Edm5

  • Epiphyseal Dysplasia, Fairbank Type

  • Epiphyseal Dysplasia, Ribbing Type

  • Multiple Epiphyseal Dysplasia, Autosomal Dominant

  • Multiple Epiphyseal Dysplasia, Autosomal Recessive

  • Rmed

  • Dysplasia, Epiphyseal, Multiple

  • Osteochondrodysplasias
Short-Rib Thoracic Dysplasia 3 With Or Without Polydactyly

  • Asphyxiating Thoracic Dystrophy 3

  • Saldino-Noonan Syndrome

  • SRTD3

  • Atd3

  • Srps1

  • Srps3

  • Verma-Naumoff Syndrome

  • Srps2b

  • Short Rib-Polydactyly Syndrome, Verma-Naumoff Type

  • Short Rib-Polydactyly Syndrome, Type I

  • Polydactyly With Neonatal Chondrodystrophy, Type I

  • Polydactyly With Neonatal Chondrodystrophy, Type Iii

  • Short Rib-Polydactyly Syndrome, Type Iib

  • Short Rib-Polydactyly Syndrome Type 3

  • Polydactyly With Neonatal Chondrodystrophy Type Iii

  • Short Rib-Polydactyly Syndrome Type Iii

  • Short Rib-Polydactyly Syndrome Type 1

  • Short Rib-Polydactyly Syndrome, Saldino-Noonan Type

  • Majewski Syndrome

  • Short Rib-Polydactyly Syndrome, Type Iii

  • Type I Short Rib Polydactyly Syndrome

  • Srps Type 3

  • Short Rib Polydactyly Syndrome Verma Naumoff Type

  • Verma Naumoff Syndrome

  • Polydactyly With Neonatal Chondrodystrophy Type 1

  • Srps Type 1

  • Short Rib-Polydactyly Syndrome Saldino-Noonan Type

  • Jatd

  • Jeune Asphyxiating Thoracic Dystrophy

  • Jeune Syndrome 3

  • Polydactyly With Neonatal Chondrodystrophy Type I

  • Short Rib-Polydactyly Syndrome Type I

  • Short Rib-Polydactyly Syndrome Type Iib

  • Srps Type Iib

  • Srps Type Iii
Atrioventricular Septal Defect

  • AVSD

  • Atrioventricular Canal Defect

  • Avcd

  • Endocardial Cushion Defect

  • Ecd

  • Avc Defect

  • Atrioventricular Septal Defect, Susceptibility To, 1

  • Atrioventricular Septal Defect 1

  • Endocardial Cushion Defects

  • Septal Defect, Atrioventricular

  • Atrioventricular Defect With Atrial Shunting Only

  • Incomplete Atrioventricular Septal Defect With Isolated Atrial Component

  • Incomplete Atrioventricular Canal Defect With Isolated Atrial Component

  • Primum Atrial Septal Defect

  • Partial Atrioventricular Canal Defect With Isolated Atrial Component

  • Partial Atrioventricular Septal Defect, Ostium Primum Type

  • Ostium Primum Atrial Septal Defect

  • Partial Atrioventricular Canal Defect

  • Partial Atrioventricular Septal Defect

  • Atrial Septum Primum Defect

  • Atrioventricular Canal Defect With Isolated Ventricular Component

  • Atrioventricular Canal Defect With Isolated Ventricular Communication

  • Atrioventricular Septal Defect With Isolated Ventricular Component

  • Atrioventricular Septal Defect With Atrial Shunting And Restrictive Ventricular Shunting

  • Intermediate Atrioventricular Canal Defect With Atrial And Ventricular Components And Separate Atrioventricular Valve

  • Transitional Atrioventricular Septal Defect With Atrial And Ventricular Components And Separate Atrioventricular Valves

  • Atrioventricular Canal Defect Associated With A Restrictive Ventricular Septal Defect

  • Intermediate Atrioventricular Canal Defect

  • Intermediate Atrioventricular Septal Defect With Atrial And Ventricular Components And Separate Atrioventricular Valvar Orifices

  • Intermediate Atrioventricular Septal Defect

  • Transitional Atrioventricular Canal Defect

  • Transitional Atrioventricular Septal Defect

  • Complete Atrioventricular Canal With Atrial And Ventricular Components

  • Complete Atrioventricular Canal Defect

  • Complete Atrioventricular Septal Defect
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03164 CRELD2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18196 Creld2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24670 Creld2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CRELD2 MGD MGI:1923987
Bos taurus CRELD2 VGNC VGNC:27705
Macaca mulatta CRELD2 VGNC VGNC:84579
Rattus norvegicus CRELD2 RGD RGD:1310614
Felis catus CRELD2 VGNC VGNC:83541
Canis familiaris CRELD2 VGNC VGNC:39608
Others CRELD2 NCBI