BIRC7 - baculoviral IAP repeat containing 7 Gene

Also Known as KIAP; LIVIN; MLIAP; RNF50; ML-IAP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 79444

About BIRC7

Cytogenetic location: 20q13.33 Genomic coordinates (GRCh38): 20:63,235,905-63,240,495 (from NCBI)

This gene has 3 transcripts (splice variants), 156 orthologues and 7 paralogues. Biased expression in placenta (RPKM 3.1), skin (RPKM 0.7) and 5 other tissues.

Summary

This gene encodes a member of the inhibitor of Apoptosis protein (IAP) family, and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is essential for inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit Apoptosis alone. Elevated levels of the encoded protein may be associated with Cancer progression and play a role in chemotherapy sensitivity. Alternative splicing results in multiple transcript variants [provided by RefSeq, Jul 2013]

BIRC7 Products (2)

mRNA	Protein	Name
NM_022161.4	NP_071444.1	baculoviral IAP repeat-containing protein 7 isoform beta
NM_139317.3	NP_647478.1	baculoviral IAP repeat-containing protein 7 isoform alpha

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11024045	GOA
enables ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	16729033	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	16729033	GOA
involved in negative regulation of tumor necrosis factor-mediated signaling pathway	IDA IDA: Inferred from direct assay	11865055	GOA
involved in positive regulation of JNK cascade	IDA IDA: Inferred from direct assay	11865055	GOA
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	16729033	GOA
acts upstream of negative effect regulation of apoptotic process	IDA IDA: Inferred from direct assay	11865055	GOA
involved in regulation of cell population proliferation	IDA IDA: Inferred from direct assay	21617971	GOA
involved in regulation of natural killer cell apoptotic process	IDA IDA: Inferred from direct assay	18034418	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	17294084	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	17294084	GOA
located in nucleus	IDA IDA: Inferred from direct assay	17294084	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BIRC7 Protein Structure

BIR

zf-C3HC4_3

0
100
200
298 a.a.

Protein Preferred Names	Protein Names
baculoviral IAP repeat-containing protein 7	RING finger protein 50

BIRC7 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	BIRC7	Q96CA5	BOLA1	Homo sapiens	Q9Y3E2	Validated Y2H	32296183
Intra	BIRC7	Q96CA5	POLR1C	Homo sapiens	O15160	Y2H Prey Pooling	25416956
Intra	BIRC7	Q96CA5	POLR1C	Homo sapiens	O15160	Validated Y2H	25416956
Intra	BIRC7	Q96CA5	LCOR	Homo sapiens	Q96JN0-2	Validated Y2H	32296183
Intra	BIRC7	Q96CA5	TEPSIN	Homo sapiens	Q96N21	Validated Y2H	32296183
Intra	BIRC7	Q96CA5	DDX6	Homo sapiens	P26196	Y2H Array	25416956
Intra	BIRC7	Q96CA5	AURKC	Homo sapiens	Q9UQB9	Validated Y2H	32296183
Intra	BIRC7	Q96CA5	UBE2K	Homo sapiens	P61086	Validated Y2H	32814053
Intra	BIRC7	Q96CA5	UBE2K	Homo sapiens	P61086	Y2H Pooling	32814053
Intra	BIRC7	Q96CA5	UBE2K	Homo sapiens	P61086	Y2H Array	32814053
Intra	BIRC7	Q96CA5	BIRC2	Homo sapiens	Q13490	Anti Tag CoIP	33961781
Intra	BIRC7	Q96CA5	BIRC2	Homo sapiens	Q13490	Anti Tag CoIP	28514442
Intra	BIRC7	Q96CA5	BIRC2	Homo sapiens	Q13490	Y2H Array	31515488
Intra	BIRC7	Q96CA5	BIRC2	Homo sapiens	Q13490	Y2H Prey Pooling	25416956
Intra	BIRC7	Q96CA5	BIRC2	Homo sapiens	Q13490	Validated Y2H	25416956
Intra	BIRC7	Q96CA5	CASP9	Homo sapiens	P55211	Y2H Prey Pooling	25416956
Intra	BIRC7	Q96CA5	CASP9	Homo sapiens	P55211	Anti Tag CoIP	11801603
Intra	BIRC7	Q96CA5	CASP9	Homo sapiens	P55211	CoIP	11024045
Intra	BIRC7	Q96CA5	CASP9	Homo sapiens	P55211	Pull Down	11801603
Intra	BIRC7	Q96CA5	HTRA2	Homo sapiens	O43464	Anti Tag CoIP	33961781
Intra	BIRC7	Q96CA5	HTRA2	Homo sapiens	O43464	FPS	11801603
Intra	BIRC7	Q96CA5	HTRA2	Homo sapiens	O43464	Pull Down	11801603
Intra	BIRC7	Q96CA5	DIABLO	Homo sapiens	Q9NR28	Pull Down	11801603
Intra	BIRC7	Q96CA5	DIABLO	Homo sapiens	Q9NR28	Anti Tag CoIP	11801603
Intra	BIRC7	Q96CA5	DIABLO	Homo sapiens	Q9NR28	Anti Tag CoIP	33961781
Intra	BIRC7	Q96CA5	TLE5	Homo sapiens	Q08117	Validated Y2H	25416956
Intra	BIRC7	Q96CA5	TLE5	Homo sapiens	Q08117	Y2H Array	25416956
Intra	BIRC7	Q96CA5	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	32296183
Intra	BIRC7	Q96CA5	FAM124B	Homo sapiens	Q9H5Z6	Y2H Prey Pooling	25416956
Intra	BIRC7	Q96CA5	FAM124B	Homo sapiens	Q9H5Z6	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant BIRC7 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77065	Livin/BIRC7 Protein, Human (His)	Q96CA5-1 (M1-S298)	≥ 95%, as determined by reducing SDS-PAGE.

BIRC7 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P86950	Livin Antibody (YA6643)	WB, IHC-P, IP	Human

Related Diseases

Diseases	Alias
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Microphthalmia	Microphthalmos Isolated Anophthalmia-Microphthalmia Syndrome Isolated Microphthalmia-Anophthalmia-Coloboma Simple Microphthalmos Clinical Anophthalmia Isolated Anophthalmia - Microphthalmia Isolated Pure Microphthalmia Mac Spectrum Microphthalmia-Anophthalmia-Coloboma Spectrum Primitive Anophthalmia Globe Of Eye Small Small Eyeball Hypoplasia Of Eye Isolated Nanophthalmos Rudimentary Eye Dysplasia Of Eye
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Renal Cell Carcinoma, Nonpapillary	Renal Cell Carcinoma RCC Nonpapillary Renal Cell Carcinoma Clear Cell Renal Cell Carcinoma Hypernephroma Adenocarcinoma Of Kidney Renal Carcinoma, Chromophobe, Somatic Clear Cell Carcinoma Of Kidney Clear-Cell Metastatic Renal Cell Carcinoma Clear Cell Renal Carcinoma Renal Cell Carcinoma, Somatic Conventional Renal Cell Carcinoma Conventional Renal Cell Carcinoma Renal Clear Cell Carcinoma Ccrcc Hereditary Clear Cell Renal Cell Carcinoma Carcinoma, Renal Cell Renal Cell Carcinoma, Clear Cell, Somatic Renal Cell Carcinoma, Clear Cell Clear Cell Kidney Carcinoma Clear Cell Rcc Cystic-Multilocular Variant Clear Cell Renal Cell Adenocarcinoma Hereditary Clear Cell Renal Cell Adenocarcinoma Common Renal Cell Carcinoma Crcc Renal Cell Carcinoma Non-Papillary Carcinoma Renal Cell Renal Cell Cancer Carcinoma, Renal Cell, Nonpapillary
Leukemia, Chronic Lymphocytic	Chronic Lymphocytic Leukemia B-Cell Chronic Lymphocytic Leukemia CLL B-Cell Chronic Lymphoid Leukemia Chronic Lymphatic Leukemia Chronic Lymphocytic Leukaemia Lymphoplasmacytic Leukemia Small Lymphocytic Lymphoma Leukemia, Chronic Lymphatic B-Cell Chronic Lymphocytic Leukaemia Chronic Lymphatic Leukaemia Lymphoplasmacytic Leukaemia B Cell Chronic Lymphocytic Leukemia Chronic B-Cell Lymphocytic Leukemia Leukemia, Lymphocytic, Chronic B-Cll Chronic Lymphoid Leukemia Leukemia Lymphocytic Chronic Lymphoma Small Lymphocytic Leukemia, Lymphocytic, Chronic, B-Cell

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-50685	A 410099.1	Inhibitor	99.30%	Unkown
HY-184595	(6-OH)-SBP-0636457		/	Unkown
HY-RS01515	BIRC7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20864	Birc7 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27379	Birc7 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	BIRC7	VGNC	VGNC:60119
Mus musculus	BIRC7	MGD	MGI:2676458
Macaca mulatta	BIRC7	VGNC	VGNC:70302
Canis familiaris	BIRC7	VGNC	VGNC:38463
Bos taurus	BIRC7	VGNC	VGNC:26503
Rattus norvegicus	BIRC7	RGD	RGD:1562883
Others	BIRC7	NCBI