Acvr1 - activin A receptor type 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 79558

About Acvr1

Primary_assembly 3: 42,978,561-43,098,241 reverse strand.mRatBN7.2:CM026976.1

This gene has 2 transcripts (splice variants), 174 orthologues, 11 paralogues and is associated with 11 phenotypes. Biased expression in Heart (RPKM 32.9), Kidney (RPKM 31.) and 9 other tissues.

Summary

Enables activin receptor activity, type I. Involved in cellular response to glucocorticoid stimulus; regulation of skeletal muscle tissue development; and transforming growth factor beta receptor signaling pathway. Acts upstream of or within urogenital system development. Part of activin receptor complex. Human ortholog(s) of this gene implicated in fibrodysplasia ossificans progressiva. Orthologous to human ACVR1 (Activin A receptor type 1). [provided by Alliance of Genome Resources, Apr 2022]

Acvr1 Products (1)

mRNA	Protein	Name
NM_024486.1	NP_077812.1	activin receptor type-1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables activin receptor activity, type I	IDA IDA: Inferred from direct assay	8248234	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to glucocorticoid stimulus	IEP IEP: Inferred from expression pattern	16150914	RGD
involved in regulation of skeletal muscle tissue development	IEP IEP: Inferred from expression pattern	12968668	RGD
involved in transforming growth factor beta receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	12968668	RGD
acts upstream of or within urogenital system development	IMP IMP: Inferred from mutant phenotype	11376112	RGD

Cellular Component GO Annotation	Evidence	References	Source
part of activin receptor complex	IDA IDA: Inferred from direct assay	8248234	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Acvr1 Protein Structure

Activin_recp

TGF_beta_GS

STKc_ACVR1_ALK1

0
100
200
300
400
500
528 a.a.

Protein Preferred Names	Protein Names
activin receptor type-1	ACTR-I ALK2-B SKR1 TGF-B superfamily receptor type I TSR-I activin A receptor, type I activin receptor type I activin type I receptor serine/threonine-protein kinase receptor R1

Recombinant Acvr1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75538	ACVR1 Protein, Rat (HEK293, hFc)	P80201 (M21-E123)	≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-109179A	Itacnosertib hydrochloride	Inhibitor	99.43%	Phase 2

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P990022	Prafnosbart	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (16)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-112815	ALK2-IN-2	Inhibitor	99.93%	Unkown
HY-109179	Itacnosertib	Inhibitor	99.06%	Unkown
HY-RS00242	ACVR1C Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00243	Acvr1c Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-112414	ALK2-IN-7	Inhibitor	/	Unkown
HY-RS00236	ACVR1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00237	Acvr1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00238	Acvr1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00239	ACVR1B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00240	Acvr1b Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00241	Acvr1b Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00244	Acvr1c Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W064657	Momelotinib dihydrochloride	Inhibitor	99.56%	Unkown
HY-174784	Human ACVR1C mRNA		/	Unkown
HY-174785	Human ACVR1B mRNA		/	Unkown
HY-174786	Human ACVR1 mRNA		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Acvr1	NCBI	NCBI:90