2. Gene
  3. Acvr1 - activin A receptor type 1 Gene

Acvr1 - activin A receptor type 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 79558 | Gene type: protein coding

About Acvr1

Primary_assembly 3: 42,978,561-43,098,241 reverse strand.mRatBN7.2:CM026976.1

This gene has 2 transcripts (splice variants), 174 orthologues, 11 paralogues and is associated with 11 phenotypes. Biased expression in Heart (RPKM 32.9), Kidney (RPKM 31.) and 9 other tissues.

Summary

Enables activin receptor activity, type I. Involved in cellular response to glucocorticoid stimulus; regulation of skeletal muscle tissue development; and transforming growth factor beta receptor signaling pathway. Acts upstream of or within urogenital system development. Part of activin receptor complex. Human ortholog(s) of this gene implicated in fibrodysplasia ossificans progressiva. Orthologous to human ACVR1 (Activin A receptor type 1). [provided by Alliance of Genome Resources, Apr 2022]

Acvr1 Products(1)

mRNA Protein Name
NM_024486.1 NP_077812.1 activin receptor type-1 precursor

Acvr1 Protein Structure

Activin_recp

Activin_recp: pfam01064 (51 - 120)

TGF_beta_GS

TGF_beta_GS: pfam08515 (197 - 224)

STKc_ACVR1_ALK1

STKc_ACVR1_ALK1: cd14142 (220 - 517)

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  • 528 a.a.
Protein Preferred Names Protein Names

activin receptor type-1

ACTR-I

ALK2-B

SKR1

TGF-B superfamily receptor type I

TSR-I

activin A receptor, type I

activin receptor type I

activin type I receptor

serine/threonine-protein kinase receptor R1

Recombinant Acvr1 Proteins

Cat. No. Product Name Accession Purity
HY-P75538 ACVR1 Protein, Rat (HEK293, hFc) P80201 (M21-E123) ≥95%

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-109179 Itacnosertib Inhibitor 99.77% Phase 2
Pre-clinical Phase
Bioactive Molecules (10)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-109179A Itacnosertib (hydrocholide) Inhibitor 98.98% Unkown
HY-RS00236 ACVR1 Human Pre-designed siRNA Set A / Unkown
HY-RS00237 Acvr1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS00238 Acvr1 Rat Pre-designed siRNA Set A / Unkown
HY-RS00239 ACVR1B Human Pre-designed siRNA Set A / Unkown
HY-RS00240 Acvr1b Mouse Pre-designed siRNA Set A / Unkown
HY-RS00241 Acvr1b Rat Pre-designed siRNA Set A / Unkown
HY-RS00242 ACVR1C Human Pre-designed siRNA Set A / Unkown
HY-RS00243 Acvr1c Mouse Pre-designed siRNA Set A / Unkown
HY-RS00244 Acvr1c Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Acvr1 NCBI NCBI:90
Canis familiaris Acvr1 NCBI NCBI:478757
Macaca fascicularis Acvr1 NCBI NCBI:102134051
Mus musculus Acvr1 NCBI NCBI:11477
Macaca mulatta Acvr1 NCBI NCBI:697935