MANEA - mannosidase endo-alpha Gene

Also Known as ENDO; hEndo

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79694

About MANEA

Cytogenetic location: 6q16.1 Genomic coordinates (GRCh38): 6:95,577,535-95,609,452 (from NCBI)

This gene has 11 transcripts (splice variants), 200 orthologues and 1 paralogue. Ubiquitous expression in urinary bladder (RPKM 7.3), thyroid (RPKM 6.8) and 25 other tissues.

Summary

N-glycosylation of proteins is initiated in the endoplasmic reticulum (ER) by the transfer of the preassembled oligosaccharide glucose-3-mannose-9-N-acetylglucosamine-2 from dolichyl pyrophosphate to acceptor sites on the target protein by an oligosaccharyltransferase complex. This core oligosaccharide is sequentially processed by several ER glycosidases and by an endomannosidase (E.C. 3.2.1.130), such as MANEA, in the Golgi. MANEA catalyzes the release of mono-, di-, and triglucosylmannose oligosaccharides by cleaving the alpha-1,2-mannosidic bond that links them to high-mannose glycans (Hamilton et al., 2005 [PubMed 15677381]).[supplied by OMIM, Sep 2008]

MANEA Products (1)

mRNA Protein Name
NM_024641.4 NP_078917.2 glycoprotein endo-alpha-1,2-mannosidase

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables glycoprotein endo-alpha-1,2-mannosidase activity IDA
IDA: Inferred from direct assay
15760709 GOA
Cellular Component GO Annotation Evidence References Source
is active in Golgi membrane IDA
IDA: Inferred from direct assay
15760709 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

glycoprotein endo-alpha-1,2-mannosidase

  • alpha 1,2-endomannosidase

Related Diseases

Diseases Alias
Congenital Disorder Of Glycosylation, Type Iib

  • CDG2B

  • CDGIIB

  • Glucosidase I Deficiency

  • Congenital Disorder Of Glycosylation Type Iib

  • Cdg Iib

  • Mogs-Cdg

  • Cdg Syndrome Type Iib

  • Cdg-Iib

  • Carbohydrate Deficient Glycoprotein Syndrome Type Iib

  • Congenital Disorder Of Glycosylation Type 2b

  • Glucosidase 1 Deficiency

  • Type Iib Congenital Disorder Of Glycosylation

  • Glycosylation, Congenital Disorder Of, Type Iib
Mannosidosis, Beta A, Lysosomal

  • Beta-Mannosidosis

  • Lysosomal Beta-Mannosidase Deficiency

  • Beta-Mannosidase Deficiency

  • Beta-D-Mannosidosis

  • Mannosidosis, Beta

  • MANSB

  • Lysosomal Beta A Mannosidosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08015 MANEA Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus MANEA RGD RGD:620327
Felis catus MANEA VGNC VGNC:102455
Mus musculus MANEA MGD MGI:2444484
Bos taurus MANEA VGNC VGNC:31169
Canis familiaris MANEA VGNC VGNC:42950
Macaca mulatta MANEA VGNC VGNC:74326
Others MANEA NCBI