KDM8 - lysine demethylase 8 Gene

Also Known as JMJD5

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 79831

About KDM8

Cytogenetic location: 16p12.1 Genomic coordinates (GRCh38): 16:27,203,526-27,221,768 (from NCBI)

This gene has 14 transcripts (splice variants), 205 orthologues and 4 paralogues. Broad expression in liver (RPKM 13.5), small intestine (RPKM 5.4) and 18 other tissues.

Summary

This gene likely encodes a histone lysine demethylase. Studies of a similar protein in mouse indicate a potential role for this protein as a tumor suppressor. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2009]

KDM8 Products (2)

mRNA	Protein	Name
NM_001145348.2	NP_001138820.1	bifunctional peptidase and arginyl-hydroxylase JMJD5 isoform 1
NM_024773.3	NP_079049.2	bifunctional peptidase and arginyl-hydroxylase JMJD5 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables aminopeptidase activity	IDA IDA: Inferred from direct assay	28847961	GOA
enables chromatin binding	IDA IDA: Inferred from direct assay	20457893	GOA
enables endopeptidase activity	IDA IDA: Inferred from direct assay	28847961	GOA
enables histone H3K36 demethylase activity	IDA IDA: Inferred from direct assay	20457893	GOA
enables methylated histone binding	IDA IDA: Inferred from direct assay	28847961	GOA
enables peptidyl-arginine 3-dioxygenase activity	EXP EXP: Inferred from Experiment	29563586	GOA
enables peptidyl-arginine 3-dioxygenase activity	IDA IDA: Inferred from direct assay	29563586	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	24981860	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in G2/M transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	20457893	GOA
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	30500822	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	20457893	GOA
involved in protein destabilization	IMP IMP: Inferred from mutant phenotype	30500822	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in nucleus	IDA IDA: Inferred from direct assay	20457893	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KDM8 Protein Structure

Cupin_8

0
100
200
300
416 a.a.

Protein Preferred Names	Protein Names
bifunctional peptidase and arginyl-hydroxylase JMJD5	JmjC arginyl-hydroxylase

KDM8 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	KDM8	Q8N371	RCCD1	Homo sapiens	A6NED2	Anti Bait CoIP	24981860

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Glycogen Storage Disease Xv	GSD15 Gsd Xv Glycogenin Deficiency Gyg1 Deficiency Glycogen Storage Disease Type Xv Glycogen Storage Disease With Severe Cardiomyopathy Due To Glycogenin Deficiency Gsd Type 15 Gsd Type Xv Gsd With Severe Cardiomyopathy Due To Glycogenin Deficiency Glycogen Storage Disease Type 15 Glycogenosis Type 15 Glycogenosis Type Xv Glycogenosis With Severe Cardiomyopathy Due To Glycogenin Deficiency Glycogen Storage Disease 15 Storage Disease, Glycogen, Type Xv

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS07225	KDM8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20759	Kdm8 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27272	Kdm8 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	KDM8	VGNC	VGNC:80586
Mus musculus	KDM8	MGD	MGI:1924285
Bos taurus	KDM8	VGNC	VGNC:30534
Canis familiaris	KDM8	VGNC	VGNC:42330
Macaca mulatta	KDM8	VGNC	VGNC:81426
Rattus norvegicus	KDM8	RGD	RGD:1304823
Others	KDM8	NCBI