VCPIP1 - valosin containing protein interacting protein 1 Gene

Also Known as DUBA3; VCIP135

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 80124

About VCPIP1

Cytogenetic location: 8q13.1 Genomic coordinates (GRCh38): 8:66,628,487-66,667,231 (from NCBI)

This gene has 1 transcript (splice variant) and 209 orthologues. Ubiquitous expression in bone marrow (RPKM 10.6), spleen (RPKM 6.5) and 25 other tissues.

Summary

Enables thiol-dependent Deubiquitinase. Involved in protein deubiquitination; protein-DNA covalent cross-linking repair; and regulation of protein localization to chromatin. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

VCPIP1 Products (1)

mRNA	Protein	Name
NM_025054.5	NP_079330.2	deubiquitinating protein VCPIP1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cysteine-type deubiquitinase activity	IDA IDA: Inferred from direct assay	23827681	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA damage response	IDA IDA: Inferred from direct assay	32649882	GOA
involved in protein K11-linked deubiquitination	IDA IDA: Inferred from direct assay	23827681	GOA
involved in protein K48-linked deubiquitination	IDA IDA: Inferred from direct assay	23827681	GOA
involved in protein deubiquitination	IDA IDA: Inferred from direct assay	32649882	GOA
involved in protein-DNA covalent cross-linking repair	IDA IDA: Inferred from direct assay	32649882	GOA
involved in regulation of protein localization to chromatin	IDA IDA: Inferred from direct assay	32649882	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	32649882	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VCPIP1 Protein Structure

OTU

0
200
400
600
800
1000
1222 a.a.

Protein Preferred Names	Protein Names
deubiquitinating protein VCPIP1	VCP/p47 complex-interacting 135-kDa protein

Related Diseases

Diseases	Alias
Inclusion Body Myopathy With Paget Disease Of Bone And Frontotemporal Dementia	Ibmpfd Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal Dementia Pagetoid Amyotrophic Lateral Sclerosis Pagetoid Neuroskeletal Syndrome Inclusion Body Myopathy With Paget Disease Of Bone And/Or Frontotemporal Dementia Inclusion Body Myopathy With Early-Onset Paget Disease Of Bone And/Or Frontotemporal Dementia Multisystem Proteinopathy Limb-Girdle Muscular Dystrophy With Paget Disease Of Bone Inclusion Body Myopathy With Paget'S Disease Of Bone And Frontotemporal Dementia Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal Dement Lower Motor Neuron Degeneration With Paget-Like Bone Disease Muscular Dystrophy, Limb-Girdle, With Paget Disease Of Bone Myopathy, Inclusion Body, With Early-Onset Paget Disease And Frontotemporal Dementia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-159000	VCPIP1-IN-2	Inhibitor	98.0%	Unkown
HY-158999	VCPIP1-IN-1		99.53%	Unkown
HY-RS15624	VCPIP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19827	Vcpip1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26324	Vcpip1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	VCPIP1	VGNC	VGNC:48244
Rattus norvegicus	VCPIP1	RGD	RGD:708520
Felis catus	VCPIP1	VGNC	VGNC:66934
Macaca mulatta	VCPIP1	VGNC	VGNC:79895
Mus musculus	VCPIP1	MGD	MGI:1917925
Others	VCPIP1	NCBI