MFAP5 - microfibril associated protein 5 Gene

Homo sapiens

Also known as AAT9; MP25; MAGP2; MAGP-2; MFAP-5

Gene ID: 8076 | Gene type: protein coding

About MFAP5

Cytogenetic location: 12p13.31 Genomic coordinates (GRCh38): 12:8,645,943-8,662,826 (from NCBI)

This gene has 15 transcripts (splice variants), 185 orthologues, 1 paralogue and is associated with 2 phenotypes. Biased expression in fat (RPKM 53.2), endometrium (RPKM 51.6) and 11 other tissues.

Summary

This gene encodes a 25-kD microfibril-associated glycoprotein which is a component of microfibrils of the extracellular matrix. The encoded protein promotes attachment of cells to microfibrils via alpha-V-beta-3 Integrin. Deficiency of this gene in mice results in neutropenia. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]

MFAP5 Products(5)

mRNA	Protein	Name
NM_001297709.2	NP_001284638.1	microfibrillar-associated protein 5 isoform b precursor
NM_001297710.2	NP_001284639.1	microfibrillar-associated protein 5 isoform c precursor
NM_001297711.2	NP_001284640.1	microfibrillar-associated protein 5 isoform d precursor
NM_001297712.2	NP_001284641.1	microfibrillar-associated protein 5 isoform e precursor
NM_003480.4	NP_003471.1	microfibrillar-associated protein 5 isoform a precursor

MFAP5 Protein Structure

MAGP

0
100
173 a.a.

Protein Preferred Names

Protein Names

microfibrillar-associated protein 5

THE1A-MFAP5

Recombinant MFAP5 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76494	MAGP-2/MFAP5 Protein, Human (HEK293, His)	Q13361-1 (I22-L173)	≥95%

Related Diseases

Diseases

Alias

Aortic Aneurysm, Familial Thoracic 9

AAT9	Aortic Aneurysm, Thoracic, With Or Without Aortic Dissection
Aneurysm, Aortic, Thoracic, Familial, Type 9

Aortic Aneurysm, Familial Thoracic 1

Thoracic Aortic Aneurysm	Annuloaortic Ectasia
Familial Thoracic Aortic Aneurysm And Aortic Dissection	Familial Aortic Dissection
Familial Taad	Familial Thoracic Aortic Aneurysm
Congenital Aneurysm Of Ascending Aorta	Familial Aortic Aneurysm
Familial Thoracic Aortic Aneurysm And Dissection	Aortic Aneurysm, Thoracic
AAT1	Faa1
Aortic Dissection, Familial	Aortic Aneurysm, Familial Thoracic
Aneurysm, Thoracic Aortic	Faa
Ftaad	Taa
Taad	Cystic Medial Necrosis Of Aorta
Familial Non-Syndromic Thoracic Aortic Aneurysm And Aortic Dissection	Aortic Aneurysm Thoracic
Familial Aortic Aneurysms	Aneurysm, Aortic, Thoracic, Familial, Type 1
Aneurysm Of Thoracic Aorta	Intrathoracic Aneurysm
Thoracic Aorta Aneurysm	Thoracic Aortic Aneurysm Without Rupture
Thoracic Aneurysm	Thorax Arterial Aneurysm
Thoracic Artery Aneurysm	Thoracic Arterial Aneurysm
Thorax Aneurysm	Thorax Aortic Aneurysm
Dissection Of Thoracic Aorta

Aortic Aneurysm

Aortic Rupture	Thoracoabdominal Aortic Aneurysm, Ruptured
Ruptured Aortic Aneurysm	Aortic Aneurysms
Aortic Aneurysm Without Mention Of Rupture Nos	Ruptured Abdominal Aortic Aneurysm
Aortic Aneurysm, Ruptured	Ruptured Thoracic Aortic Aneurysm

Contractural Arachnodactyly, Congenital

Congenital Contractural Arachnodactyly	Beals Syndrome
CCA	Beals-Hecht Syndrome
Distal Arthrogryposis Type 9	Arthrogryposis, Distal, Type 9
Da9	Arachnodactyly, Contractural Beals Type
Contractures, Multiple With Arachnodactyly	Ear Anomalies-Contractures-Dysplasia Of Bone With Kyphoscoliosis
Arthrogyroposis, Distal, Type 9	Distal Arthrogyropsis Type 9
Cca Syndrome	Arachnodactyly

Loeys-Dietz Syndrome

Loeys-Dietz Aortic Aneurysm Syndrome	Lds
Aortic Aneurysm Syndrome Due To Tgf-Beta Receptors Anomalies	Furlong Syndrome

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Cancer Of The Ovary
Epithelial Ovarian Cancer	Neoplasm Of Ovary
Ovarian Neoplasms	Ovarian Cancers
Malignant Neoplasm Of Ovary	Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic	Malignant Ovarian Tumor
Ovary Neoplasm	Primary Ovarian Cancer
Tumor Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Aortic Dissection

Ehlers-Danlos Syndrome

Eds	Cutis Hyperelastica
Elastic Skin	Ehlers-Danlos Syndromes
Ed Syndrome	Ehlers Danlos Syndrome
Ehlers Danlos Disease	Eds - [Ehlers-Danlos Syndrome]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08379	MFAP5 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	MFAP5	VGNC	VGNC:31425
Canis familiaris	MFAP5	VGNC	VGNC:43191
Mus musculus	MFAP5	MGD	MGI:1354387
Macaca mulatta	MFAP5	VGNC	VGNC:74621
Rattus norvegicus	MFAP5	RGD	RGD:1307919
Others	MFAP5	NCBI

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