Bdkrb1 - bradykinin receptor B1 Gene

Also Known as BKR; Bdkrb; b1bkr

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 81509

About Bdkrb1

Primary_assembly 6: 124,510,870-124,513,747 forward strand.mRatBN7.2:CM026979.1

This gene has 1 transcript (splice variant), 147 orthologues, 8 paralogues and is associated with 34 phenotypes. Biased expression in Uterus (RPKM 5.6), Adrenal (RPKM 1.6) and 3 other tissues.

Summary

Enables Bradykinin Receptor activity and peptide binding activity. Involved in several processes, including positive regulation of release of sequestered calcium ion into cytosol; protein kinase C-activating G protein-coupled receptor signaling pathway; and response to lipopolysaccharide. Located in neuron projection and plasma membrane. Used to study diabetic angiopathy; epilepsy; hypertension; neuropathy (multiple); and pleurisy. Biomarker of diabetic retinopathy; hypertension; and myocardial infarction. Human ortholog(s) of this gene implicated in end stage renal disease; hypertension; and pulmonary fibrosis. Orthologous to human BDKRB1 (Bradykinin Receptor B1). [provided by Alliance of Genome Resources, Apr 2022]

Bdkrb1 Products (1)

mRNA Protein Name
NM_030851.1 NP_110478.1 B1 bradykinin receptor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables bradykinin receptor activity IDA
IDA: Inferred from direct assay
12025968 RGD
enables peptide binding IPI
IPI: Inferred from physical interaction
10422787 RGD
Biological Process GO Annotation Evidence References Source
involved in cell migration IMP
IMP: Inferred from mutant phenotype
20411591 RGD
involved in negative regulation of blood pressure IMP
IMP: Inferred from mutant phenotype
15253105 RGD
involved in negative regulation of cell growth IMP
IMP: Inferred from mutant phenotype
16497153 RGD
involved in negative regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
16497153 RGD
involved in positive regulation of leukocyte migration IMP
IMP: Inferred from mutant phenotype
12522068 RGD
NOT involved in positive regulation of release of sequestered calcium ion into cytosol IDA
IDA: Inferred from direct assay
15319421 RGD
involved in positive regulation of release of sequestered calcium ion into cytosol IDA
IDA: Inferred from direct assay
15576455 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
19561153 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Bdkrb1 Protein Structure

7tmA_BK-1

7tmA_BK-1: cd15380 (36 - 332)

7tmA_BK-1

7tmA_BK-1: cd15380 (37 - 63)

7tmA_BK-1

7tmA_BK-1: cd15380 (81 - 106)

7tmA_BK-1

7tmA_BK-1: cd15380 (119 - 149)

7tmA_BK-1

7tmA_BK-1: cd15380 (162 - 183)

7tmA_BK-1

7tmA_BK-1: cd15380 (208 - 237)

7tmA_BK-1

7tmA_BK-1: cd15380 (252 - 282)

7tmA_BK-1

7tmA_BK-1: cd15380 (300 - 325)

  • 0
  • 100
  • 200
  • 300
  • 337 a.a.
Protein Preferred Names Protein Names

B1 bradykinin receptor

  • B1R

  • BK-1 receptor

  • KB1

  • bradykinin B1 receptor

  • bradykinin receptor, beta 1

  • kinin B1 receptor

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P4676 Lys-(Des-Arg9,Leu8)-Bradykinin Antagonist 99.78% Unkown
HY-P4676A Lys-(Des-Arg9,Leu8)-Bradykinin TFA Antagonist / Unkown
HY-RS01454 BDKRB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01455 Bdkrb1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01456 Bdkrb1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bdkrb1 NCBI NCBI:623