Atf2 - activating transcription factor 2 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 81647

Summary

Enables cAMP response element binding activity. Involved in several processes, including amelogenesis; positive regulation of neuron apoptotic process; and regulation of transcription by RNA polymerase II. Located in nucleus. Used to study hypertension and transient cerebral ischemia. Biomarker of glaucoma and transient cerebral ischemia. Orthologous to human ATF2 (activating transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Atf2 Products (2)

mRNA Protein Name
NM_031018.2 NP_112280.1 cyclic AMP-dependent transcription factor ATF-2
NM_031018.2 NP_112280.1 cyclic AMP-dependent transcription factor ATF-2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cAMP response element binding IDA
IDA: Inferred from direct assay
12196528 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
17428807 RGD
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
17428807 RGD
Biological Process GO Annotation Evidence References Source
involved in amelogenesis IDA
IDA: Inferred from direct assay
15218628 RGD
involved in negative regulation of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
20181929 RGD
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
20181929 RGD
involved in positive regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
19255142 RGD
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12453892 RGD
Cellular Component GO Annotation Evidence References Source
part of CCAAT-binding factor complex IDA
IDA: Inferred from direct assay
8703044 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cyclic AMP-dependent transcription factor ATF-2

  • cAMP response element-binding protein CRE-BP1

  • cAMP-dependent transcription factor ATF-2

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B1198 Piperonyl butoxide Inhibitor 98.0% Unkown
HY-B1198R Piperonyl butoxide (Standard) Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-13241A Ralimetinib Inhibitor 98.58% Phase 2
HY-152860 Darizmetinib 99.94% Phase 1

Pre-clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-13241 Ralimetinib dimesylate 99.97% Unkown
HY-134963 SBI-0087702 99.55% Unkown
HY-117987 CPS-11 99.39% Unkown
HY-B1198S Piperonyl butoxide-d9 Inhibitor 98.68% Unkown
HY-RS01128 ATF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W585976 Benzo[a]pyrene diol epoxide 90.0% Unkown
HY-180419 SF-3-030 / Unkown
HY-RS05361 GDNF Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-107091R Aspartyl-alanyl-diketopiperazine (Standard) Inhibitor / Unkown
HY-RS17003 Atf2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23446 Atf2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Atf2 NCBI NCBI:1386