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Dbn1 - drebrin 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 81653

Summary

Enables actin filament binding activity; cytoskeletal motor inhibitor activity; and profilin binding activity. Involved in several processes, including positive regulation of cell development; regulation of nervous system process; and regulation of organelle organization. Located in several cellular components, including axon; dendrite; and lamellipodium. Is active in glutamatergic synapse; postsynaptic actin cytoskeleton; and postsynaptic membrane. Colocalizes with actin filament. Biomarker of Parkinson's disease; cognitive disorder; sciatic neuropathy; temporal lobe epilepsy; and transient cerebral ischemia. Orthologous to human DBN1 (drebrin 1). [provided by Alliance of Genome Resources, Apr 2022]

Dbn1 Products (1)

mRNA	Protein	Name
NM_031024.2	NP_112286.1	drebrin

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables actin filament binding	IDA IDA: Inferred from direct assay	17543276	RGD
enables cytoskeletal motor inhibitor activity	IDA IDA: Inferred from direct assay	17543276	RGD
enables cytoskeletal protein binding	IPI IPI: Inferred from physical interaction	22319661	RGD
enables profilin binding	IDA IDA: Inferred from direct assay	9473484	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	16025302	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to X-ray	IEP IEP: Inferred from expression pattern	23578130	RGD
involved in cellular response to transforming growth factor beta stimulus	IDA IDA: Inferred from direct assay	22319661	RGD
involved in cellular response to tumor necrosis factor	IDA IDA: Inferred from direct assay	22319661	RGD
involved in lung alveolus development	IEP IEP: Inferred from expression pattern	15928322	RGD
involved in modulation of inhibitory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	19174472	RGD
involved in negative regulation of actin filament bundle assembly	IDA IDA: Inferred from direct assay	8769857	RGD
involved in negative regulation of locomotion involved in locomotory behavior	IMP IMP: Inferred from mutant phenotype	15140563	RGD
involved in negative regulation of muscle filament sliding	IDA IDA: Inferred from direct assay	17543276	RGD
involved in nervous system development	IEP IEP: Inferred from expression pattern	1611026	RGD
involved in positive regulation of axon extension	IMP IMP: Inferred from mutant phenotype	19222710	RGD
involved in positive regulation of cell-substrate adhesion	IDA IDA: Inferred from direct assay	7478237	RGD
involved in positive regulation of dendritic spine morphogenesis	IMP IMP: Inferred from mutant phenotype	19174472	RGD
involved in positive regulation of excitatory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	19174472	RGD
involved in positive regulation of neuron projection development	IDA IDA: Inferred from direct assay	19222710	RGD
involved in positive regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	10320758	RGD
involved in positive regulation of substrate adhesion-dependent cell spreading	IDA IDA: Inferred from direct assay	7478237	RGD
involved in postsynaptic actin cytoskeleton organization	IDA IDA: Inferred from direct assay	12878700	RGD
involved in postsynaptic actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	12878700	RGD
involved in prepulse inhibition	IMP IMP: Inferred from mutant phenotype	15140563	RGD
involved in regulation of actin filament polymerization	IMP IMP: Inferred from mutant phenotype	19222710	RGD
involved in regulation of filopodium assembly	IMP IMP: Inferred from mutant phenotype	12878700	RGD
involved in regulation of postsynaptic density protein 95 clustering	IMP IMP: Inferred from mutant phenotype	12878700	RGD
involved in response to activity	IEP IEP: Inferred from expression pattern	21262320	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	14623141	RGD
involved in spermatogenesis	IEP IEP: Inferred from expression pattern	22319661	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in actin filament	IDA IDA: Inferred from direct assay	10234022	RGD
located in asymmetric synapse	IDA IDA: Inferred from direct assay	15700273	RGD
located in axonal growth cone	IDA IDA: Inferred from direct assay	19222710	RGD
located in axonal spine	IDA IDA: Inferred from direct assay	15700273	RGD
located in cell-cell junction	IDA IDA: Inferred from direct assay	22319661	RGD
located in dendritic filopodium	IDA IDA: Inferred from direct assay	12878700	RGD
located in dendritic shaft	IDA IDA: Inferred from direct assay	12878700	RGD
located in dendritic spine	IDA IDA: Inferred from direct assay	12878700	RGD
located in excitatory synapse	IDA IDA: Inferred from direct assay	15700273	RGD
located in filopodium	IDA IDA: Inferred from direct assay	19222710	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	8929425	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	12878700	RGD
located in lamellipodium	IDA IDA: Inferred from direct assay	19222710	RGD
located in neuron spine	IDA IDA: Inferred from direct assay	10234022	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	18304746	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	22319661	RGD
is active in postsynaptic actin cytoskeleton	IDA IDA: Inferred from direct assay	8929425	RGD
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	15700273	RGD
located in postsynaptic membrane	IDA IDA: Inferred from direct assay	19539702	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
drebrin	developmentally-regulated brain protein drebrin E

Dbn1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Dbn1	Q07266	Pten	Rattus norvegicus	O54857	Anti Bait CoIP	23940795
Intra	Dbn1	Q07266	Zmynd8	Rattus norvegicus	A8C4G9	IF	24117785
Intra	Dbn1	Q07266	Zmynd8	Rattus norvegicus	A8C4G9	Y2H	24117785
Intra	Dbn1	Q07266	Zmynd8	Rattus norvegicus	A8C4G9	Pull Down	24117785

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03548	DBN1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21320	Dbn1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27839	Dbn1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dbn1	NCBI	NCBI:1627