Lum - lumican Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 81682

Summary

Predicted to enable Collagen binding activity. Involved in cartilage development; response to growth factor; and response to organic cyclic compound. Located in extracellular matrix. Biomarker of ureteral obstruction. Human ortholog(s) of this gene implicated in carotid artery disease; coronary artery disease; and pancreatic Cancer. Orthologous to human LUM (lumican). [provided by Alliance of Genome Resources, Apr 2022]

Lum Products (1)

mRNA Protein Name
NM_031050.2 NP_112312.1 lumican precursor

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in cartilage development IEP
IEP: Inferred from expression pattern
19746167 RGD
involved in response to growth factor IEP
IEP: Inferred from expression pattern
18482974 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
18602130 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

lumican

  • KSPG lumican

  • keratan sulfate proteoglycan lumican

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-16747 Maralixibat chloride Inhibitor 99.61% Unkown

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-101190 Volixibat 99.76% Phase 2

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-101190A (3R,4S,5S)-Volixibat 99.14% Unkown
HY-163539A Pegulicianine / Unkown
HY-RS07891 LUM Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17525 Lum Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23982 Lum Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lum NCBI NCBI:4060