Actr3 - actin related protein 3 Gene

Also Known as Arp3

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 81732

Summary

Enables ATPase binding activity and actin binding activity. Involved in several processes, including neurogenesis; positive regulation of cellular component organization; and positive regulation of protein localization to membrane. Located in several cellular components, including apical ectoplasmic specialization; basal ectoplasmic specialization; and concave side of sperm head. Part of apical tubulobulbar complex. Is active in glutamatergic synapse and postsynapse. Colocalizes with actin filament. Used to study focal segmental glomerulosclerosis. Biomarker of focal segmental glomerulosclerosis and schizophrenia. Human ortholog(s) of this gene implicated in opisthorchiasis. Orthologous to human ACTR3 (actin related protein 3). [provided by Alliance of Genome Resources, Apr 2022]

Actr3 Products (1)

mRNA Protein Name
NM_031068.1 NP_112330.1 actin-related protein 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATPase binding IPI
IPI: Inferred from physical interaction
23403943 RGD
enables actin binding IDA
IDA: Inferred from direct assay
20566646 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
18064521 RGD
Biological Process GO Annotation Evidence References Source
involved in Sertoli cell barrier remodeling IEP
IEP: Inferred from expression pattern
20534520 RGD
involved in astrocyte differentiation IMP
IMP: Inferred from mutant phenotype
23843614 RGD
involved in cellular response to epidermal growth factor stimulus IEP
IEP: Inferred from expression pattern
10209028 RGD
involved in cellular response to interleukin-1 IEP
IEP: Inferred from expression pattern
21191089 RGD
involved in cellular response to pyrimidine ribonucleotide IEP
IEP: Inferred from expression pattern
22065602 RGD
involved in cellular response to transforming growth factor beta stimulus IDA
IDA: Inferred from direct assay
22319661 RGD
involved in cellular response to trichostatin A IEP
IEP: Inferred from expression pattern
12445420 RGD
involved in cellular response to triterpenoid IEP
IEP: Inferred from expression pattern
20566646 RGD
involved in cellular response to tumor necrosis factor IDA
IDA: Inferred from direct assay
22319661 RGD
involved in negative regulation of axon extension IMP
IMP: Inferred from mutant phenotype
19846719 RGD
involved in negative regulation of bleb assembly IMP
IMP: Inferred from mutant phenotype
22786929 RGD
involved in positive regulation of actin filament polymerization IMP
IMP: Inferred from mutant phenotype
18256280 RGD
involved in positive regulation of astrocyte differentiation IMP
IMP: Inferred from mutant phenotype
23843614 RGD
involved in positive regulation of dendrite morphogenesis IMP
IMP: Inferred from mutant phenotype
18430734 RGD
involved in positive regulation of dendritic spine morphogenesis IMP
IMP: Inferred from mutant phenotype
23441206 RGD
involved in positive regulation of fibroblast migration IMP
IMP: Inferred from mutant phenotype
20566646 RGD
involved in positive regulation of filopodium assembly IMP
IMP: Inferred from mutant phenotype
18256280 RGD
involved in positive regulation of lamellipodium assembly IMP
IMP: Inferred from mutant phenotype
18256280 RGD
involved in positive regulation of neuron differentiation IMP
IMP: Inferred from mutant phenotype
18256280 RGD
involved in positive regulation of protein localization to plasma membrane IMP
IMP: Inferred from mutant phenotype
21844200 RGD
involved in positive regulation of protein targeting to membrane IMP
IMP: Inferred from mutant phenotype
20739464 RGD
involved in positive regulation of synapse assembly IMP
IMP: Inferred from mutant phenotype
18430734 RGD
involved in postsynapse organization IDA
IDA: Inferred from direct assay
18430734 RGD
involved in postsynapse organization IMP
IMP: Inferred from mutant phenotype
18430734 RGD
involved in postsynaptic actin cytoskeleton organization IDA
IDA: Inferred from direct assay
18430734 RGD
involved in postsynaptic actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
18430734 RGD
involved in regulation of actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
20739464 RGD
involved in regulation of myosin II filament organization IMP
IMP: Inferred from mutant phenotype
18256280 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
19095743 RGD
involved in response to heparin IEP
IEP: Inferred from expression pattern
17488504 RGD
involved in spermatogenesis IEP
IEP: Inferred from expression pattern
20534520 RGD
Cellular Component GO Annotation Evidence References Source
located in Golgi membrane IDA
IDA: Inferred from direct assay
15147909 RGD
located in actin filament IDA
IDA: Inferred from direct assay
10209028 RGD
located in apical ectoplasmic specialization IDA
IDA: Inferred from direct assay
23546604 RGD
part of apical tubulobulbar complex IDA
IDA: Inferred from direct assay
22797892 RGD
located in basal ectoplasmic specialization IDA
IDA: Inferred from direct assay
23546604 RGD
located in cell leading edge IDA
IDA: Inferred from direct assay
17855387 RGD
located in cell-cell junction IDA
IDA: Inferred from direct assay
22319661 RGD
located in concave side of sperm head IDA
IDA: Inferred from direct assay
22332112 RGD
located in excitatory synapse IDA
IDA: Inferred from direct assay
18430734 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
18430734 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
18430734 RGD
located in hemidesmosome IDA
IDA: Inferred from direct assay
15093736 RGD
located in lamellipodium IDA
IDA: Inferred from direct assay
15252126 RGD
located in leading edge of lamellipodium IDA
IDA: Inferred from direct assay
17855387 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
22319661 RGD
located in podosome IDA
IDA: Inferred from direct assay
15093736 RGD
located in podosome core IDA
IDA: Inferred from direct assay
24290759 RGD
is active in postsynapse EXP
EXP: Inferred from Experiment
15020595 RGD
is active in postsynapse IDA
IDA: Inferred from direct assay
15020595 RGD
is active in postsynapse IMP
IMP: Inferred from mutant phenotype
18430734 RGD
located in ruffle IDA
IDA: Inferred from direct assay
10209028 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

actin-related protein 3

  • ARP3 actin related protein 3 homolog

  • actin-like protein 3

  • actin-related protein 3 homolog (yest)

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00231 ACTR3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00232 ACTR3B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19403 Actr3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25895 Actr3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Actr3 NCBI NCBI:10096