Ntf3 - neurotrophin 3 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 81737

Summary

Enables nerve growth factor binding activity. Involved in modulation of chemical synaptic transmission; nervous system development; and response to immobilization stress. Predicted to be located in cytoplasmic vesicle. Predicted to be active in several cellular components, including axon; dendrite; and synaptic vesicle. Biomarker of status epilepticus. Human ortholog(s) of this gene implicated in Alzheimer's disease and asthma. Orthologous to human NTF3 (neurotrophin 3). [provided by Alliance of Genome Resources, Apr 2022]

Ntf3 Products (4)

mRNA Protein Name
NM_001270868.1 NP_001257797.1 neurotrophin-3 isoform 2
NM_001270869.1 NP_001257798.1 neurotrophin-3 isoform 1
NM_001270870.1 NP_001257799.1 neurotrophin-3 isoform 3 precursor
NM_031073.3 NP_112335.3 neurotrophin-3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables nerve growth factor binding IMP
IMP: Inferred from mutant phenotype
2164684 RGD
Biological Process GO Annotation Evidence References Source
involved in modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
14507970 RGD
involved in myelination IDA
IDA: Inferred from direct assay
15139015 RGD
involved in nervous system development IMP
IMP: Inferred from mutant phenotype
2164684 RGD
involved in positive regulation of glial cell differentiation IDA
IDA: Inferred from direct assay
15139015 RGD
involved in response to immobilization stress IEP
IEP: Inferred from expression pattern
7568018 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neurotrophin-3

  • HDNF

  • NGF-2

  • NT-3

  • nerve growth factor 2

  • neurotrophic factor

  • neurotrophin-3 (HDNF/NT-3)

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09616 NTF3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20313 Ntf3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26821 Ntf3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ntf3 NCBI NCBI:4908