P2rx3 - purinergic receptor P2X 3 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 81739

About P2rx3

Primary_assembly 3: 70,080,851-70,125,178 reverse strand.mRatBN7.2:CM026976.1

This gene has 2 transcripts (splice variants), 275 orthologues, 6 paralogues and is associated with 2 phenotypes. Biased expression in Kidney (RPKM 11.6), Adrenal (RPKM 5.2) and 9 other tissues.

Summary

Enables several functions, including ATP binding activity; extracellularly ATP-gated cation channel activity; and identical protein binding activity. Involved in several processes, including behavioral response to formalin induced pain; neuronal action potential; and positive regulation of sensory perception of pain. Located in several cellular components, including dendritic spine; membrane raft; and rough endoplasmic reticulum. Is integral component of plasma membrane. Is integral component of presynaptic membrane. Orthologous to human P2RX3 (purinergic receptor P2X 3). [provided by Alliance of Genome Resources, Apr 2022]

P2rx3 Products (2)

mRNA Protein Name
NM_001270621.1 NP_001257550.1 P2X purinoceptor 3 isoform 2
NM_031075.2 NP_112337.2 P2X purinoceptor 3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
12581826 RGD
enables extracellularly ATP-gated monoatomic cation channel activity IDA
IDA: Inferred from direct assay
7566119 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
15313628 RGD
enables purinergic nucleotide receptor activity IDA
IDA: Inferred from direct assay
7566119 RGD
Biological Process GO Annotation Evidence References Source
involved in behavioral response to formalin induced pain IMP
IMP: Inferred from mutant phenotype
24120766 RGD
involved in cellular response to ATP IDA
IDA: Inferred from direct assay
7566119 RGD
involved in neuronal action potential IDA
IDA: Inferred from direct assay
12581826 RGD
Cellular Component GO Annotation Evidence References Source
located in dendritic spine IDA
IDA: Inferred from direct assay
9721930 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
9721930 RGD
located in plasma membrane IMP
IMP: Inferred from mutant phenotype
7566119 RGD
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
26801076 RGD
located in terminal bouton IDA
IDA: Inferred from direct assay
9721930 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

P2rx3 Protein Structure

P2X_receptor

P2X_receptor: pfam00864 (26 - 378)

  • 0
  • 100
  • 200
  • 300
  • 416 a.a.
Protein Preferred Names Protein Names

P2X purinoceptor 3

  • ATP receptor

  • P2X3

  • purinergic receptor P2X, ligand-gated ion channel, 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09903 P2RX3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09904 P2rx3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09905 P2rx3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens P2rx3 NCBI NCBI:5024