Thra - thyroid hormone receptor alpha Gene

Also Known as ERBA1; Thra1; c-erbA-1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 81812

Summary

Enables DNA-binding transcription factor activity, RNA polymerase II-specific; nucleic acid binding activity; and protein homodimerization activity. Involved in several processes, including animal organ development; digestive tract development; and regulation of transcription, DNA-templated. Located in cytosol; mitochondrion; and nucleus. Human ortholog(s) of this gene implicated in congenital nongoitrous hypothyroidism 6 and renal cell carcinoma. Orthologous to human THRA (Thyroid Hormone Receptor alpha). [provided by Alliance of Genome Resources, Apr 2022]

Thra Products (2)

mRNA Protein Name
NM_001017960.2 NP_001017960.1 thyroid hormone receptor alpha isoform TRalpha1
NM_031134.2 NP_112396.2 c-erbAalpha2 isoform TRalpha2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
12039959 RGD
enables intronic transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
20368265 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
20078863 RGD
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
8407924 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
8407924 RGD
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
8407924 RGD
enables single-stranded RNA binding IDA
IDA: Inferred from direct assay
16356627 RGD
Biological Process GO Annotation Evidence References Source
involved in adrenal gland development IEP
IEP: Inferred from expression pattern
17496154 RGD
involved in digestive tract development IEP
IEP: Inferred from expression pattern
17496154 RGD
involved in embryonic organ development IEP
IEP: Inferred from expression pattern
17496154 RGD
involved in kidney development IEP
IEP: Inferred from expression pattern
17496154 RGD
involved in liver development IEP
IEP: Inferred from expression pattern
17496154 RGD
involved in lung development IEP
IEP: Inferred from expression pattern
17496154 RGD
involved in negative regulation of DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
2537467 RGD
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12039959 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
19794517 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
18930353 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

thyroid hormone receptor alpha

c-erbAalpha2

  • C-erbA-alpha

  • avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 1

  • c-erb-A thyroid hormone receptor

  • c-erbA-alpha2

  • nuclear receptor subfamily 1 group A member 1

  • thyroid hormone receptor alpha 1 (avian erythroblastic leukemia viral (v-erb-a)

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14499 THRA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17595 Thra Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24055 Thra Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Thra NCBI NCBI:7067