Pax8 - paired box 8 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 81819

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in regulation of transcription, DNA-templated and sulfur compound metabolic process. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in nucleoplasm. Human ortholog(s) of this gene implicated in congenital hypothyroidism and congenital nongoitrous hypothyroidism 2. Orthologous to human PAX8 (paired box 8). [provided by Alliance of Genome Resources, Apr 2022]

Pax8 Products (1)

mRNA Protein Name
NM_031141.2 NP_112403.2 paired box protein Pax-8

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
15888455 RGD
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
1508216 RGD
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
1508216 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
12441357 RGD
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
11145590 RGD
Biological Process GO Annotation Evidence References Source
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
9214635 RGD
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
1508216 RGD
involved in regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
11145590 RGD
involved in sulfur compound metabolic process IEP
IEP: Inferred from expression pattern
12237116 RGD
Cellular Component GO Annotation Evidence References Source
located in nucleoplasm IDA
IDA: Inferred from direct assay
12441357 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

paired box protein Pax-8

  • Pax-8 protein

  • paired box gene 8

Pax8 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Pax8 P51974 Nkx2-1 Rattus norvegicus P23441
Pull Down
12441357
Intra
Pax8 P51974 Wbp2 Rattus norvegicus Q8R478
Phage Display
14531730
Intra
Pax8 P51974 Wbp2 Rattus norvegicus Q8R478
Pull Down
14531730
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10095 PAX8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174555 Human PAX8 mRNA / Unkown
HY-RS18962 Pax8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25453 Pax8 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pax8 NCBI NCBI:7849