PAX8 - paired box 8 Gene

Also Known as PAX-8

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7849

About PAX8

Cytogenetic location: 2q14.1 Genomic coordinates (GRCh38): 2:113,215,997-113,278,921 (from NCBI)

This gene has 14 transcripts (splice variants), 167 orthologues, 50 paralogues and is associated with 85 phenotypes. Biased expression in thyroid (RPKM 261.2) and kidney (RPKM 40.3).

Summary

This gene encodes a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins that contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2010]

PAX8 Products (4)

mRNA Protein Name
NM_003466.4 NP_003457.1 paired box protein Pax-8 isoform PAX8A
NM_013952.4 NP_039246.1 paired box protein Pax-8 isoform PAX8C
NM_013953.4 NP_039247.1 paired box protein Pax-8 isoform PAX8D
NM_013992.4 NP_054698.1 paired box protein Pax-8 isoform PAX8E

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
8861958 GOA
enables DNA binding IMP
IMP: Inferred from mutant phenotype
9590296 GOA
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
9388203 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
9388203 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19010321 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
15356023 GOA
Biological Process GO Annotation Evidence References Source
involved in DNA-templated transcription IDA
IDA: Inferred from direct assay
9590296 GOA
involved in branching involved in ureteric bud morphogenesis IEP
IEP: Inferred from expression pattern
1337742 GOA
involved in cellular response to gonadotropin stimulus IDA
IDA: Inferred from direct assay
15961562 GOA
involved in central nervous system development IEP
IEP: Inferred from expression pattern
15494458 GOA
involved in kidney development IEP
IEP: Inferred from expression pattern
15494458 GOA
involved in mesenchymal to epithelial transition involved in metanephros morphogenesis IEP
IEP: Inferred from expression pattern
8861958 GOA
involved in metanephric S-shaped body morphogenesis IEP
IEP: Inferred from expression pattern
1337742 GOA
involved in metanephric comma-shaped body morphogenesis IEP
IEP: Inferred from expression pattern
1337742 GOA
involved in metanephric epithelium development IEP
IEP: Inferred from expression pattern
7856737 GOA
involved in otic vesicle development IEP
IEP: Inferred from expression pattern
15494458 GOA
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
8413205 GOA
involved in positive regulation of thyroid hormone generation IMP
IMP: Inferred from mutant phenotype
15356023 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
9388203 GOA
involved in regulation of thyroid-stimulating hormone secretion IMP
IMP: Inferred from mutant phenotype
15356023 GOA
involved in thyroid gland development IEP
IEP: Inferred from expression pattern
1337742 GOA
involved in thyroid gland development IMP
IMP: Inferred from mutant phenotype
9590296 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
9388203 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PAX8 Protein Structure

PAX

PAX: 'Paired box' domain (9 - 133)

  • 0
  • 100
  • 200
  • 300
  • 398 a.a.
Protein Preferred Names Protein Names

paired box protein Pax-8

  • paired domain gene 8

PAX8 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PAX8 Q06710 TLE5 Homo sapiens Q08117-2
Validated Y2H
32296183
Intra
PAX8 Q06710 CDK3 Homo sapiens Q00526
Y2H Prey Pooling
32296183
Intra
PAX8 Q06710 LONRF1 Homo sapiens Q17RB8
Validated Y2H
32296183
Intra
PAX8 Q06710 NCL Homo sapiens P19338
Display Tech
20195357
Intra
PAX8 Q06710 DOK4 Homo sapiens Q8TEW6
Validated Y2H
32296183
Intra
PAX8 Q06710 SAE1 Homo sapiens Q9UBE0
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PAX8 Proteins

Cat. No. Product Name Accession Purity
HY-P74651 PAX8 Protein, Human (His) Q06710 (P2-S146) ≥ 95%, as determined by reducing SDS-PAGE.

PAX8 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83433 PAX8 Antibody (YA3178) WB, IHC-P, ICC/IF Human
HY-P84500 PAX8 Antibody (YA4197) WB, IHC-P, FC, ELISA Human
HY-P84500A PAX8 Antibody (YA4197)(PBS only) WB, IHC-P, FC, ELISA Human
HY-P85779 PAX8 Antibody (YA5471) WB Mouse
HY-P86202 PAX8 Antibody (YA5894) WB, IHC-P, ICC/IF, ELISA Human, Mouse, Rat

Related Diseases

Diseases Alias
Hypothyroidism, Congenital, Nongoitrous, 2

  • Thyroid Dysgenesis

  • CHNG2

  • Thyroid Hypoplasia

  • Thyroid Hemiagenesis

  • Thyroid Agenesis

  • Athyreotic Hypothyroidism

  • Rtsh

  • Thyrotropin Resistance

  • Hypothyroidism, Congenital, Due To Thyroid Dysgenesis Or Hypoplasia

  • Congenital Nongoitrous Hypothyroidism 2

  • Thyroid, Ectopic

  • Hypothyroidism, Congenital, Due To Thyroid Dysgenesis

  • Hypothyroidism, Athyreotic

  • Thyrotropin

  • Resistance To Thyrotropin

  • Congenital Hypothyroidism Due To Thyroid Dysgenesis Or Hypoplasia

  • Hypothyroidism, Congenital, Non-Goitrous, 2

  • Congenital Hypothyroidism Due To Thyroid Dysgenesis

  • Thyroid-Stimulating Hormone Resistance

  • Thyroid Ectopic

  • Ectopic Thyroid

  • Hypothyroidism, Congenital, Nongoitrous, 3

  • Thyroid Hormone Resistance Syndrome

  • Hypothyroidism, Congenital, Nongoitrous, 1
Athyreosis
Thyroid Ectopia
Congenital Hypothyroidism

  • Cretinism

  • Neonatal Hypothyroidism

  • Ch

  • Cht

  • Congenital Myxedema

  • Myxedema, Congenital

  • Endemic Cretinism

  • Congenital Iodine-Deficiency Syndrome

  • Fetal Iodine Deficiency Syndrome

  • Congenital Iodine-Deficiency Hypothyroidism Nos
Differentiated Thyroid Carcinoma

  • Papillary Or Follicular Thyroid Carcinoma

  • Well-Differentiated Thyroid Carcinoma

  • Differentiated Thyroid Gland Carcinoma
Hypothyroidism

  • Thyroid Diseases

  • Thyroid Disease

  • Thyroid Deficiency

  • Thyroid Insufficiency

  • Dysfunction Thyroid

  • Thyroid Dysfunction
Thyroid Gland Cancer

  • Thyroid Gland Carcinoma

  • Malignant Neoplasm Of Thyroid Gland

  • Malignant Tumour Of Thyroid Gland

  • Thyroid Neoplasm

  • Thyroid Neoplasms

  • Neoplasm Of Thyroid Gland

  • Thyroid Gland Neoplasm

  • Head And Neck Cancer, Thyroid

  • Neoplasm Of The Thyroid Gland

  • Cancer Of The Thyroid

  • Primary Malignant Neoplasm Of Thyroglossal Duct

  • Malignant Neoplasm Of Thyroglossal Duct

  • Primary Malignant Neoplasm Of Thyroid Gland

  • Thyroglossal Duct Cancer

  • Toxic Goitre Malignant Tumour

  • Cancerous Goitre
Endosalpingiosis
Goiter

  • Goitre
Follicular Adenoma

  • Follicular Adenoma Of The Thyroid Gland

  • Thyroid Follicular Adenoma

  • Adenoma Follicular

  • Follicular Thyroid Adenoma

  • Thyroid Gland Follicular Adenoma
Thyroid Gland Anaplastic Carcinoma

  • Anaplastic Thyroid Carcinoma

  • Anaplastic Thyroid Cancer

  • Thyroid Cancer, Anaplastic

  • Thyroid Carcinoma, Anaplastic

  • Thyroid Carcinoma Anaplastic
Ovarian Mesodermal Adenosarcoma

  • Ovarian Mullerian Adenosarcoma

  • Ovarian Adenosarcoma
Thymus Basaloid Carcinoma

  • Basaloid Carcinoma Of The Thymus

  • Thymic Basaloid Carcinoma
Mucinous Cystadenofibroma
Sarcomatoid Renal Cell Carcinoma

  • Renal Cell Carcinoma, Spindle Cell
Nephrogenic Adenoma

  • Nephrogenic Metaplasia
Cystadenofibroma
Bladder Clear Cell Adenocarcinoma

  • Bladder Mesonephric Adenocarcinoma

  • Clear Cell Adenocarcinoma Of Bladder
Urethra Clear Cell Adenocarcinoma

  • Clear Cell Adenocarcinoma Of The Urethra

  • Urethral Clear Cell Adenocarcinoma
Pendred Syndrome

  • Goiter-Deafness Syndrome

  • Deafness With Goiter

  • PDS

  • Thyroid Dyshormonogenesis 2b

  • Tdh2b

  • Autosomal Recessive Sensorineural Hearing Impairment And Goiter

  • Pendred'S Syndrome

  • Thyroid Hormonogenesis, Genetic Defect In, 2b

  • Hypothyroidism, Congenital, Due To Dyshormonogenesis, 2b

  • Congenital Hypothyroidism Due To Dyshormonogenesis 2b

  • Genetic Defect In Thyroid Hormonogenesis 2b

  • Autosomal Recessive Sensorineural Hearing Impairment, Enlarged Vestibular Aqueduct, And Goiter

  • Goiter-Hearing Loss Syndrome

  • Goitre-Deafness Syndrome

  • Goitre Deafness
Urethra Adenocarcinoma

  • Adenocarcinoma Of The Urethra

  • Urethral Adenocarcinoma
Epithelioid Type Angiomyolipoma

  • Epithelioid Angiomyolipoma
Ovarian Mucinous Neoplasm

  • Ovarian Mucinous Tumor

  • Malignant Ovarian Mucinous Neoplasm

  • Mucinous Tumor Of Ovary

  • Malignant Ovarian Mucinous Tumor
Benign Teratoma

  • Dermoid Cyst

  • Cystic Dermoid Choristoma

  • Dermoid Choristoma

  • Mature Cystic Teratoma

  • Dermoid Tumour

  • Teratoma, Benign

  • Dermoid Cyst Of Ovary
Fallopian Tube Carcinoma

  • Fallopian Tube Cancer

  • Cancer Of The Fallopian Tube

  • Carcinoma Of Fallopian Tube

  • Neoplasm Of Fallopian Tube

  • Fallopian Tube Neoplasms

  • Fallopian Tube Ca

  • Fallopian Tube Neoplasm

  • Malignant Neoplasm Of Uterine Tube

  • Malignant Tumor Of Fallopian Tube

  • Malignant Tumour Of Fallopian Tube

  • Tumor Of The Fallopian Tube

  • Tumor, Fallopian Tube, Malignant

  • Malignant Tumor Of Fallopian Tubes

  • Cancer Of Fallopian Tubes

  • Malignant Tubal Tumor

  • Tubal Cancer

  • Malignant Neoplasm Of Fallopian Tube

  • Primary Malignant Neoplasm Of Fallopian Tube

  • Cancer Of The Oviduct
Thymus Clear Cell Carcinoma

  • Clear Cell Carcinoma Of The Thymus

  • Thymic Clear Cell Carcinoma
Renal Pelvis Adenocarcinoma

  • Adenocarcinoma Of Renal Pelvis

  • Adenocarcinoma Of The Kidney Pelvis
Ovarian Seromucinous Carcinoma

  • Mixed Epithelial Carcinoma Of Ovary

  • Ovary Mixed Epithelial Carcinoma
Chronic Salpingitis
Vulvar Sebaceous Carcinoma
Atypical Follicular Adenoma
Rete Testis Neoplasm
Rete Testis Adenocarcinoma

  • Adenocarcinoma Of Rete Testis

  • Adenocarcinoma Of The Rete Testis
Hemangioblastoma

  • Capillary Hemangioblastoma
Thyroid Gland Mucoepidermoid Carcinoma

  • Mucoepidermoid Thyroid Carcinoma
Thyroid Angiosarcoma

  • Hemangiosarcoma Of The Thyroid
Angiomyolipoma

  • Angiomyolipoma Of Kidney
Thyroid Sarcoma

  • Sarcoma Of The Thyroid Gland

  • Thyroid Gland Sarcoma
Wolffian Duct Adenocarcinoma

  • Cervical Mesonephric Adenocarcinoma
Graves' Disease

  • Graves Disease

  • Exophthalmic Goiter

  • Basedow'S Disease

  • Grave'S Disease

  • Basedow Disease

  • Toxic Diffuse Goiter

  • Graves' Hyperthyroidism

  • Parry Disease

  • Autoimmune Hyperthyroidism

  • Toxic Multinodular Goiter
Thyroid Gland Follicular Carcinoma

  • Follicular Thyroid Carcinoma

  • Follicular Adenocarcinoma

  • Follicular Adenocarcinoma, Well Differentiated

  • Follicular Carcinoma

  • Thyroid Adenocarcinoma

  • Adenocarcinoma, Follicular
Ovarian Benign Neoplasm

  • Benign Ovarian Neoplasm
Carcinosarcoma

  • Mixed Tumor, Mullerian

  • Malignant Mixed Mesodermal Tumor

  • Malignant Mixed Mullerian Tumor

  • Mmmt

  • Mixed Tumor, Mesodermal

  • Mesodermal Mixed Tumor

  • Mixed Mesodermal Tumor

  • Mullerian Mixed Tumor

  • Mixed Mullerian Tumor

  • Malignant Mixed Müllerian Tumor

  • Mixed Müllerian Tumor

  • Mixed Tumor Mullerian

  • Mixed Tumor, Not Otherwise Specified
Rete Testis Adenoma
Urethral Diverticulum

  • Urethral Sacculation
Wolffian Duct Adenoma

  • Benign Mesonephroma

  • Mesonephric Adenoma

  • Mesonephroma, Benign

  • Fatwo

  • Female Adnexal Tumor Of Probable Wolffian Origin

  • Wat

  • Wolffian Adenoma

  • Wolffian Adnexal Tumor

  • Wolffian Tumor
Glycogen-Rich Clear Cell Breast Carcinoma

  • Glycogen-Rich Carcinoma
Mediastinum Sarcoma

  • Sarcoma Of Mediastinum
Nephrogenic Adenoma Of Urinary Bladder

  • Nephrogenic Adenoma Of The Urinary Bladder
Papillary Carcinoma

  • Carcinoma, Papillary

  • Carcinoma Papillary
Thyroid Malformation
Serous Cystadenocarcinoma

  • Serous Adenocarcinoma

  • Cystadenocarcinoma, Serous

  • Serous Carcinoma

  • Cystadenocarcinoma Serous
Kidney Benign Neoplasm

  • Renal And Ureteral Tumor

  • Benign Kidney Neoplasm
Fallopian Tube Adenocarcinoma

  • Adenocarcinoma Of The Fallopian Tube
Thyroid Cancer, Nonmedullary, 2

  • Thyroid Carcinoma, Follicular

  • Follicular Thyroid Carcinoma

  • NMTC2

  • Thyroid Cancer, Follicular

  • Thyroid Carcinoma, Follicular, Somatic

  • Ftc

  • Thyroid Cancer, Non-Medullary, 2

  • Thyroid Follicular Carcinoma

  • Follicular Thyroid Cancer

  • Cancer, Thyroid, Nonmedullary, Type 2

  • Thyroid Gland Adenocarcinoma

  • Follicular Carcinoma Of Unspecified Site

  • Moderately Differentiated Follicular Carcinoma Of Thyroid Gland

  • Pure Follicle Carcinoma Of Thyroid Gland

  • Pure Follicle Follicular Carcinoma Of Unspecified Site

  • Pure Follicular Carcinoma Of Thyroid Gland

  • Trabecular Follicular Carcinoma Of Thyroid Gland

  • Trabecular Follicular Carcinoma Of Unspecified Site

  • Well Differentiated Follicular Carcinoma Of Unspecified Site

  • Well Differentiated Follicular Carcinoma Of Thyroid Gland
Ovarian Large-Cell Neuroendocrine Carcinoma

  • Non-Small-Cell Type Neuroendocrine Carcinoma Of Ovary

  • Ovarian Large Cell Neuroendocrine Carcinoma
Bladder Benign Neoplasm
Endocervical Carcinoma

  • Carcinoma Of Endocervix

  • Carcinoma Of The Endocervix
Ovarian Mixed Germ Cell Neoplasm

  • Mixed Germ Cell Tumor Of Ovary

  • Ovarian Mixed Germ Cell Tumor
Collecting Duct Carcinoma

  • Kidney Medullary Carcinoma

  • Renal Medullary Carcinoma

  • Bdc

  • Bellini Carcinoma

  • Bellini Duct Carcinoma

  • Cdc

  • Collecting Duct Carcinoma Of The Kidney

  • Renal Cell Adenocarcinoma

  • Carcinoma Of Renal Collecting Duct

  • Renal Carcinoma, Collecting Duct Type

  • Renal Cell Carcinoma

  • Bellini'S Duct Carcinoma

  • Renal Collecting Duct Carcinoma

  • Adenocarcinoma Of Kidney
Nasal Cavity Olfactory Neuroblastoma

  • Olfactory Neuroblastoma Of The Nasal Cavity
Peritoneum Cancer

  • Peritoneal Neoplasm

  • Cancer Of Peritoneum

  • Malignant Tumor Of Peritoneum

  • Peritoneal Neoplasms
Combined Thymoma
Mixed Type Thymoma

  • Thymoma, Mixed Type

  • Thymoma, Type Ab
Benign Struma Ovarii
Epididymis Adenocarcinoma

  • Adenocarcinoma Of The Epididymis
Water-Clear Cell Adenoma
Epididymis Cancer

  • Malignant Tumor Of Epididymis

  • Malignant Epididymal Tumor

  • Malignant Neoplasm Of Epididymis

  • Neoplasm Of Epididymis
Thyroid Gland Disease

  • Abnormality Of The Thyroid Gland

  • Thyroid Diseases
Urethra Cancer

  • Cancer Of Urethra

  • Malignant Tumour Of Urethra

  • Malignant Urethral Neoplasm

  • Urethral Ca
Renal Adenoma

  • Renal Cell Adenoma
Peritoneal Serous Adenocarcinoma

  • Primary Peritoneal Serous Adenocarcinoma
Papillary Serous Adenocarcinoma

  • Micropapillary Serous Carcinoma

  • Serous Surface Papillary Carcinoma

  • Papillary Serous Carcinoma

  • Papillary Serous Cystadenocarcinoma
Thyroid Dyshormonogenesis 1

  • TDH1

  • Hypothyroidism, Congenital, Due To Dyshormonogenesis, 1

  • Genetic Defect In Thyroid Hormonogenesis 1

  • Thyroid Hormonogenesis, Genetic Defect In, 1

  • Iodine Accumulation, Transport, Or Trapping Defect

  • Iodide Accumulation, Transport, Or Trapping Defect

  • Chdh1

  • Congenital Hypothyroidism Due To Dyshormonogenesis Type 1

  • Iodine Accumulation, Transport Or Trapping Defect
Cystic Teratoma

  • Dermoid Cyst

  • Benign Teratoma
Perivascular Epithelioid Cell Tumor

  • Pecoma

  • Perivascular Epithelioid Cell Neoplasms

  • Neoplasm With Perivascular Epithelioid Cell Differentiation
Clear Cell Hidradenoma

  • Clear Cell Myoepithelioma

  • Eccrine Acrospiroma
Krukenberg Carcinoma

  • Krukenberg Tumor

  • Krukenberg Neoplasm

  • Krukenberg'S Tumor
Metanephric Adenoma
Adenofibroma
Endometrial Squamous Cell Carcinoma

  • Squamous Cell Carcinoma Of Endometrium
Peritoneal Mesothelioma

  • Malignant Mesothelioma Of Peritoneum

  • Advanced Malignant Mesothelioma Of Peritoneum

  • Advanced Malignant Peritoneal Mesothelioma

  • Advanced Peritoneal Malignant Mesothelioma
Ovarian Germ Cell Teratoma

  • Germ Cell Teratoma Of Ovary

  • Ovarian Teratoma
Clear Cell Adenocarcinoma

  • Mesonephroma

  • Water-Clear Cell Adenocarcinoma

  • Adenocarcinoma, Clear Cell

  • Malignant Mesonephroma

  • Mesonephroid Clear Cell Carcinoma

  • Mesonephroma, Malignant

  • Water-Clear Cell Carcinoma

  • Wolffian Duct Neoplasm

  • Adenocarcinoma Clear Cell

  • Mesonephric Tumor
Colloid Adenoma

  • Macrofollicular Adenoma
Ovarian Germ Cell Cancer

  • Ovarian Germ Cell Tumor

  • Malignant Germ Cell Tumor Of Ovary

  • Germ Cell Neoplasm Of Ovary

  • Germ Cell Tumor Of Ovary

  • Mogct

  • Malignant Ovarian Germ Cell Tumor

  • Malignant Ovarian Germ Cell Neoplasm
Thyroid Dyshormonogenesis 2a

  • TDH2A

  • Iodide Peroxidase Deficiency

  • Deficiency Of Iodide Peroxidase

  • Thyroid Peroxidase Deficiency

  • Genetic Defect In Thyroid Hormonogenesis 2a

  • Thyroid Hormonogenesis, Genetic Defect In, 2a

  • Hypothyroidism, Congenital, Due To Dyshormonogenesis, 2a

  • Chdh2a

  • Congenital Hypothyroidism Due To Dyshormonogenesis Type 2a

  • Thyroid Hormone Organification Defect 2

  • Tiod
Ovarian Mucinous Adenocarcinoma

  • Mucinous Carcinoma Of Ovary
Wilms Tumor 5

  • Wilms Tumor

  • WT5

  • Wilms Tumor Susceptibility-5

  • Wilms Tumor And Radial Bilateral Aplasia

  • Nephroblastoma

  • Wilms' Tumor

  • Wilms Tumor, Susceptibility To

  • Wtsl

  • Bilateral Radial Aplasia With Wilms Tumor

  • Embryonal Adenosarcoma

  • Embryonal Nephroma

  • Kidney Wilms Tumor

  • Kidney, Adenomyosarcoma, Embryonal

  • Kidney, Carcinosarcoma, Embryonal

  • Kidney, Embryoma

  • Kidney, Embryonal Mixed Tumor

  • Nephroma

  • Renal Adenosarcoma

  • Renal Cancer, Wilms

  • Renal Wilms Tumor

  • Tumor, Wilms

  • Hereditary Susceptibility To Wilms Tumor 5
Neuroendocrine Tumor

  • Neuroendocrine Neoplasm

  • Neuroendocrine Tumors

  • Carcinoma, Neuroendocrine
Thyroid Gland Medullary Carcinoma

  • Medullary Thyroid Carcinoma

  • Medullary Carcinoma Of The Thyroid Gland

  • Ultimobranchial Thyroid Tumor

  • Ultimobranchial Thyroid Tumour

  • Thyroid Cancer, Medullary
Cystinuria

  • CSNU

  • Cystinuria Type B

  • Cystinuria Type A

  • Cystinuria, Type I, Formerly

  • Csnu1, Formerly

  • Cystinuria, Type Ii, Formerly

  • Cystinuria, Type Iii, Formerly

  • Csnu3, Formerly

  • Cystinuria, Type Non-I, Formerly

  • Cystinuria-Lysinuria

  • Cystinuria-Lysinuria Syndrome

  • Csnu1

  • Csnu3

  • Cystinuria 1

  • Cystinuria Type A/B

  • Cystinuria Type I

  • Cystinuria Type Ii

  • Cystinuria Type Iii

  • Cystinuria Type Non-I

  • Cystinuria, Type A/B

  • Cystinuria Type 1

  • Cystinuria - Lysinuria

  • Csnu - [Cystinuria]

  • Cystine Disease
Ovarian Carcinosarcoma

  • Ovarian Malignant Mixed Mullerian Tumor

  • Mmmt Of The Ovary

  • Malignant Mixed Mullerian Tumor Of The Ovary

  • Ovarian Malignant Mixed Epithelial Mesenchymal Tumor

  • Ovarian Malignant Mesodermal Mixed Tumor

  • Ovarian Mmmt

  • Malignant Mixed Müllerian Tumor Of The Ovary

  • Ovarian Malignant Mixed Müllerian Tumor

  • Carcinosarcoma Of Ovary
Hypothyroidism, Thyroidal Or Athyroidal, With Spiky Hair And Cleft Palate

  • Bamforth-Lazarus Syndrome

  • Bamforth Syndrome

  • Hypothyroidism, Athyroidal, With Spiky Hair And Cleft Palate

  • Hypothyroidism Cleft Palate Hypothyroidism, Athyroidal, With Spiky Hair And Cleft Palate

  • Athyroidal Hypothyroidism-Spiky Hair-Cleft Palate Syndrome

  • Hypothyroidism-Cleft Palate Syndrome

  • BLS

  • Athyroidal Hypothyroidism With Spiky Hair And Cleft Palate
Mixed Cell Type Cancer

  • Malignant Mixed Neoplasm

  • Malignant Mixed Tumor

  • Mixed Neoplasm

  • Mixed Tumor, Malignant

  • Malignant Mixed Cancer

  • Mixed Tumor

  • Malignant Mixed Tumor, Not Otherwise Specified

  • Mixed Salivary Gland Tumor

  • Mixed Tumor, Not Otherwise Specified
Malignant Struma Ovarii

  • Struma Ovarii, Malignant
Endemic Goiter

  • Iodine-Deficiency-Related Endemic Goitre

  • Simple Goitre

  • Goiter, Endemic

  • Euthyroid Goiter
Renal Cell Carcinoma, Nonpapillary

  • Renal Cell Carcinoma

  • RCC

  • Nonpapillary Renal Cell Carcinoma

  • Clear Cell Renal Cell Carcinoma

  • Hypernephroma

  • Adenocarcinoma Of Kidney

  • Renal Carcinoma, Chromophobe, Somatic

  • Clear Cell Carcinoma Of Kidney

  • Clear-Cell Metastatic Renal Cell Carcinoma

  • Clear Cell Renal Carcinoma

  • Renal Cell Carcinoma, Somatic

  • Conventional Renal Cell Carcinoma

  • Conventional Renal Cell Carcinoma

  • Renal Clear Cell Carcinoma

  • Ccrcc

  • Hereditary Clear Cell Renal Cell Carcinoma

  • Carcinoma, Renal Cell

  • Renal Cell Carcinoma, Clear Cell, Somatic

  • Renal Cell Carcinoma, Clear Cell

  • Clear Cell Kidney Carcinoma

  • Clear Cell Rcc

  • Cystic-Multilocular Variant

  • Clear Cell Renal Cell Adenocarcinoma

  • Hereditary Clear Cell Renal Cell Adenocarcinoma

  • Common Renal Cell Carcinoma

  • Crcc

  • Renal Cell Carcinoma Non-Papillary

  • Carcinoma Renal Cell

  • Renal Cell Cancer

  • Carcinoma, Renal Cell, Nonpapillary
Prostatic Acinar Adenocarcinoma

  • Acinar Prostate Adenocarcinoma
Nephrogenic Adenoma Of The Urethra

  • Nephrogenic Adenoma Of Urethra
Ovarian Endodermal Sinus Tumor

  • Endodermal Sinus Tumor Of Ovary

  • Ovarian Yolk Sac Tumor

  • Endodermal Sinus Tumour Of Ovary

  • Ovarian Endodermal Sinus Tumour

  • Ovarian Yolk Sac Tumour
Multinodular Goiter
Ureterocele
Renal Oncocytoma

  • Oncocytoma, Renal

  • Oncocytoma Of Kidney

  • Renal Epithelial Oncocytic Tumor

  • Oncocytoma Kidney

  • Oncocytoma Renal

  • Kidney Oncocytoma
Ovarian Primitive Germ Cell Tumor
Glandular Cystitis

  • Cystitis Glandularis
Endocervical Adenocarcinoma

  • Endocervical Carcinoma
Gallbladder Signet Ring Cell Adenocarcinoma

  • Signet Ring Cell Carcinoma Of The Gallbladder
Papillary Adenocarcinoma

  • Infiltrating And Papillary Adenocarcinoma

  • Infiltrating Papillary Adenocarcinoma

  • Adenocarcinoma Papillary

  • Adenocarcinoma, Papillary
Thymic Carcinoma

  • Malignant Thymoma

  • Thymoma, Malignant
Cystadenocarcinoma
Appendix Cancer

  • Appendiceal Neoplasms

  • Cancer Of The Appendix

  • Malignant Neoplasm Of Appendix Vermiformis

  • Malignant Tumor Of Appendix

  • Malignant Tumor Of The Appendix

  • Malignant Neoplasm Of Appendix

  • Carcinoma Of The Appendix
Appendix Disease

  • Disorder Of Appendix
Appendix Adenocarcinoma

  • Cystadenocarcinoma

  • Mucinous Adenocarcinoma

  • Adenocarcinoma Of Appendix

  • Appendiceal Adenocarcinoma

  • Adenocarcinoma Of The Appendix

  • Colonic Type Adenocarcinoma

  • Nonmucinous Adenocarcinoma
Ovarian Serous Carcinoma

  • Ovarian Serous Adenocarcinoma
Hypothyroidism, Congenital, Nongoitrous, 1

  • Tsh Resistance

  • CHNG1

  • Hypothyroidism Due To Tsh Receptor Mutations

  • Thyrotropin Resistance

  • Thyroid-Stimulating Hormone

  • Rtsh

  • Hypothyroidism Due To Unresponsiveness To Thyrotropin

  • Congenital Nongoitrous Hypothyroidism 1

  • Thyroid-Stimulating Hormone, Resistance To

  • Hypothyroidism, Nonautoimmune

  • Hypothyroidism, Congenital, Due To Tsh Resistance

  • Hypothyroidism, Congenital, Non-Goitrous, 1

  • Congenital Hypothyroidism Due To Tsh Resistance

  • Non-Autoimmune Hypothyroidism

  • Thyroid-Stimulating Hormone Resistance

  • Hypothyroidism, Congenital, Nongoitrous, Type 1

  • Hypothyroidism, Congenital, Nongoitrous, 3

  • Thyroid Hormone Resistance Syndrome
Perivascular Tumor

  • Malignant Perivascular Cancer
Uterus Perivascular Epithelioid Cell Tumor

  • Uterine Corpus Pecoma
Laryngeal Neuroendocrine Tumor

  • Laryngeal Neuroendocrine Tumour

  • Neuroendocrine Tumor Of Larynx

  • Neuroendocrine Tumour Of Larynx

  • Neuroendocrine Neoplasm Of Larynx
Thymus Large Cell Carcinoma

  • Large Cell Carcinoma Of The Thymus

  • Thymic Large Cell Neuroendocrine Carcinoma
Papillary Adenoma

  • Glandular Papilloma

  • Adenoma
Mucinous Adenocarcinoma

  • Mucin-Producing Adenocarcinoma

  • Mucin-Secreting Adenocarcinoma

  • Mucin-Secreting Carcinoma

  • Mucous Carcinoma

  • Pseudomyxoma Peritonei With Unknown Primary Site

  • Adenocarcinoma, Mucinous
Female Reproductive Endometrioid Cancer

  • Endometrioid Tumor

  • Endometrioid Neoplasm

  • Female Reproductive Endometrioid Neoplasm
Ovary Adenocarcinoma

  • Ovarian Adenocarcinoma

  • Adenocarcinoma Of The Ovary

  • Ovarian Adenoacanthoma

  • Adenocarcinoma Of Ovary
Mixed Germ Cell Cancer

  • Mixed Germ Cell Tumor

  • Mixed Germ Cell Neoplasm

  • Mixed Germ Cell Tumour

  • Mixed Teratoma And Seminoma
Colon Leiomyosarcoma

  • Colonic Leiomyosarcoma
Alveolar Soft Part Sarcoma

  • ASPS

  • Alveolar Soft-Part Sarcoma

  • Sarcoma, Alveolar Soft Part

  • Alveolar Soft Tissue Sarcoma

  • Sarcoma Alveolar Soft Part

  • Adult Alveolar Soft-Part Sarcoma

  • Childhood Alveolar Soft-Part Sarcoma
Endometrial Adenocarcinoma

  • Endometrial Endometrioid Adenocarcinoma

  • Endometrial Adenoacanthoma

  • Endometrial Endometrioid Adenocarcinoma, Variant With Squamous Differentiation

  • Adenocarcinoma Of Endometrium

  • Adenocarcinoma Of The Endometrium

  • Adenocarcinoma Of Uterus

  • Endometrial Endometrioid Adenocarcinoma With Squamous Differentiation

  • Endometrioid Adenoma Or Carcinoma

  • Endometrioid Adenomas And Carcinomas

  • Endometrioid Carcinoma Of Endometrium

  • Endometrium Adenocarcinoma
Urethral Benign Neoplasm

  • Urethral Neoplasms

  • Neoplasm Of Urethra

  • Neoplasm. Urethra

  • Urethral Neoplasm

  • Urethral Carcinoma

  • Malignant Neoplasm Of Urethra
Renal Cell Carcinoma, Papillary, 1

  • Papillary Renal Cell Carcinoma

  • Hereditary Papillary Renal Cell Carcinoma

  • Papillary Renal Cell Carcinoma, Sporadic

  • Papillary Renal Cell Adenocarcinoma

  • RCCP

  • RCCP1

  • Renal Cell Carcinoma, Papillary

  • Renal Cell Carcinoma, Papillary, 1, Familial And Somatic

  • Chromophil Carcinoma Of Kidney

  • Papillary Kidney Carcinoma

  • Sporadic Papillary Renal Cell Carcinoma

  • Chromophil Renal Cell Carcinoma

  • Papillary Renal Carcinoma, Malignant -

  • Papillary Renal Cell Carcinoma, Bilateral -

  • Papillary Renal Cell Carcinoma, Familial -

  • Papillary Renal Cell Carcinoma, Multiple -

  • Papillary Renal Cell Carcinoma, Sporadic -

  • Renal Adenocarcinoma

  • Chromophil Rcc

  • Hprcc

  • Renal Cell Carcinoma Papillary

  • Chromophilic Renal Cell Carcinoma

  • Prcc

  • Carcinoma, Renal Cell, Papillary, Type 1

  • Type 1 Papillary Renal Cell Carcinoma

  • Renal Cell Carcinoma

  • Hereditary Papillary Renal Carcinoma
Ovarian Serous Cystadenofibroma
Ovarian Cystadenocarcinoma

  • Cystadenocarcinoma Of Ovary

  • Cystadenocarcinoma Of The Ovary
Malignant Ovarian Surface Epithelial-Stromal Neoplasm

  • Malignant Ovarian Surface Epithelial-Stromal Tumor
Epithelioid Cell Synovial Sarcoma

  • Synovial Sarcoma, Epithelioid Cell

  • Epithelioid Synovial Sarcoma
Endocrine Organ Benign Neoplasm
Lymphohistiocytoid Mesothelioma
Ovarian Serous Adenofibroma
Papillary Adenofibroma
Chromophobe Renal Cell Carcinoma

  • Chromophobe Adenocarcinoma

  • Chromophobe Carcinoma Of Kidney

  • Kidney Chromophobe

  • Renal Cell Carcinoma, Chromophobe Cell

  • Crcc

  • Chrcc

  • Chromophobe Renal Cell Adenocarcinoma

  • Chromophobe Renal Carcinoma

  • Chromophobe Carcinoma
Fallopian Tube Endometrioid Adenocarcinoma

  • Endometrioid Carcinoma Of The Fallopian Tube

  • Fallopian Tube Endometrioid Cancer

  • Fallopian Tube Endometrioid Neoplasm

  • Fallopian Tube Endometrioid Tumor
Subacute Lymphocytic Thyroiditis
Ovarian Serous Cystadenocarcinoma

  • Serous Cystadenoma

  • Cystadenoma Serous

  • Cystadenoma, Serous
Wilms Tumor 1

  • Nephroblastoma

  • Wilms Tumor

  • WT1

  • Wilms' Tumor

  • Bilateral Wilms Tumor

  • Wilms Tumor, Type 1

  • Wilms Tumor, Somatic

  • Adult Nephroblastoma

  • Wt1 Disorder

  • Renal Embryonic Tumor

  • Adult Kidney Wilms Tumor

  • Childhood Kidney Wilms Tumor

  • Nonanaplastic Kidney Wilms Tumor
Renal Hypodysplasia/Aplasia 1

  • Renal Agenesis

  • Renal Adysplasia

  • Renal Aplasia

  • RHDA1

  • Hereditary Renal Aplasia

  • Hra

  • Hereditary Urogenital Adysplasia

  • Hypodysplasia/Aplasia, Renal, Type 1

  • Congenital Absence Of Kidneys Syndrome

  • Congenital Absence Of Kidney

  • Aplastic Kidney
Cervix Carcinoma

  • Cancer Of Cervix

  • Carcinoma Of Cervix

  • Carcinoma Cervix Uteri

  • Carcinoma Of The Cervix Uteri
Cakut

  • Renal Or Urinary Tract Malformation

  • Congenital Anomalies Of Kidney And Urinary Tract

  • Congenital Anomaly Of Kidney And Urinary Tract

  • Congenital Anomalies Of The Kidney And Urinary Tract

  • Kidney And Urinary Tract, Anomalies, Congenital

  • Renal Hypodysplasia, Nonsyndromic, 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10095 PAX8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174555 Human PAX8 mRNA / Unkown
HY-RS18962 Pax8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25453 Pax8 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PAX8 MGD MGI:97492
Bos taurus PAX8 VGNC VGNC:32599
Canis familiaris PAX8 VGNC VGNC:44279
Rattus norvegicus PAX8 RGD RGD:620434
Felis catus PAX8 VGNC VGNC:68702
Macaca mulatta PAX8 VGNC VGNC:75767
Others PAX8 NCBI