H3C3 - H3 clustered histone 3 Gene

Homo sapiens

Also known as H3.1; H3/c; H3C1; H3C2; H3C4; H3C6; H3C7; H3C8; H3FC; H3C10; H3C11; H3C12; HIST1H3C

Gene ID: 8352 | Gene type: protein coding

About H3C3

Cytogenetic location: 6p22.2 Genomic coordinates (GRCh38): 6:26,045,384-26,045,869 (from NCBI)

This gene has 1 transcript (splice variant), 70 orthologues and 20 paralogues.

Summary

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]

H3C3 Products(1)

mRNA	Protein	Name
NM_003531.3	NP_003522.1	histone H3.1

H3C3 Protein Structure

Histone

0
100
136 a.a.

Protein Preferred Names

Protein Names

histone H3.1

H3 histone family, member C

Recombinant H3C3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72332	Histone H3 Protein, Human	P68431 (A2-A136)	≥95%
HY-P72335	Histone H3 Protein, Human (98a.a, His)	P68431 (P39-A136)	≥95%
HY-P72798	Histone H3 Protein, Human (His)	P68431 (A2-A136)	≥95%
HY-P72332A	Histone H3 Protein, Human (N-His)	P68431 (A2-A136)	≥95%

Related Diseases

Diseases

Alias

Histone Mutated Tumor

Histone Mutated Tumour

Brain Stem Cancer

Brain Stem Neoplasms	Malignant Neoplasm Of Brain Stem
Malignant Neoplasm Of Brainstem	Neoplasm Of Adult Brain Stem
Neoplasm Of Brain Stem	Primary Brain Stem Neoplasm
Primary Brain Stem Tumor	Brain Stem Neoplasm
Brain Stem--Cancer	Brain Stem Neoplasms, Primary

Diffuse Midline Glioma, H3 K27m-Mutant

Diffuse Intrinsic Pontine Glioma	Dipg
Infiltrative Brainstem Glioma

Childhood Brain Stem Glioma

Pediatric Glioma Of The Brainstem

Hutchinson-Gilford Progeria Syndrome

Progeria	HGPS
Hutchinson-Gilford Syndrome	Hutchinson-Gilford Progeria
Hutchinson Gilford Syndrome	Hutchinson Gilford Progeria Syndrome
Hutchinson-Gilford Disease	Progeria Of Childhood
Hutchinson-Gilford-Progeria Syndrome

Adult Brainstem Astrocytoma

Adult Brain Stem Astrocytoma

Posterior Fossa Ependymoma

Clear Cell Chondrosarcoma

Chondrosarcoma, Clear Cell

Brain Stem Glioma

Brainstem Glioma	Brainstem Neuroglial Tumor
Glioma Of Brainstem

Spinal Cord Astrocytoma

Astrocytoma Of Spinal Cord

Spinal Astrocytoma

Spinal Cord Glioma

Glial Tumor Of Spinal Cord	Glial Neoplasm Spinal Cord
Glioma Of Spinal Cord

Anaplastic Pleomorphic Xanthoastrocytoma

Charcot-Marie-Tooth Disease, X-Linked Recessive, 3

CMTX3	Charcot-Marie-Tooth Disease X-Linked Recessive 3
Charcot-Marie-Tooth Neuropathy, X-Linked Recessive, 3	Cmt3x
X-Linked Charcot-Marie-Tooth Disease Type 3	Charcot-Marie-Tooth Neuropathy X-Linked Recessive 3
Charcot-Marie-Tooth Disease, X-Linked Type 3, Recessive

High Grade Ependymoma

Ependymal Neoplasm	Ependymal Tumors
Malignant Ependymoma	Ependymal Tumor
Anaplastic Ependymoma	Experimental Organism Malignant Ependymoma
Ependymoma Of Brain

Idh-Wildtype Glioblastoma

Astrocytoma, Idh-Mutant, Grade 4

Idh-Mutant Glioblastoma

Juvenile Pilocytic Astrocytoma

Diffuse Astrocytoma

Diffuse Astrocytoma, Low Grade	Who Grade Ii Astrocytoma
Fibrillary Astrocytoma	Gemistocytic Astrocytoma
Low-Grade Diffuse Astrocytoma	Protoplasmic Astrocytoma

Spinal Cancer

Spinal Cord Neoplasm	Spinal Cord Neoplasms
Spinal Neoplasms	Intraspinal Tumor
Malignant Tumor Of The Spinal Cord	Spinal Cord Cancer
Spinal Neoplasm	Tumor Of The Spinal Cord
Tumors Spinal Cord	Intraspinal Neoplasm
Spinal Cord--Cancer

Pilomyxoid Astrocytoma

Cerebral Ventricle Cancer

Cerebral Ventricle Neoplasms	Cerebral Ventricle Neoplasm
Intraventricular Tumor Of Brain

Supratentorial Ependymoma

Low Grade Glioma

Benign Glioma

Intracranial Cavernous Angioma

Intracranial Cavernoma

Intracranial Cavernous Hemangioma

Intracranial Structure Hemangioma

Angioma Of Intracranial Structure	Hemangioma Of Intracranial Structure
Hemangioma Of Intracranial Structures

Central Nervous System Benign Neoplasm

Benign Neoplasm Of The Central Nervous System

Pilocytic Astrocytoma

Juvenile Pilocytic Astrocytoma	Grade I Astrocytic Tumor
Piloid Astrocytoma

Atypical Teratoid Rhabdoid Tumor

Rhabdoid Tumor Predisposition Syndrome	Rtps
Atypical Teratoid/Rhabdoid Tumor	Rhabdoid Predisposition Syndrome
Familial Posterior Fossa Brain Tumor Of Infancy	Familial Rhabdoid Tumor
At/Rt	Atypical Teratoid Rhabdoid Tumour
Atypical Teratoid/Rhabdoid Tumour	Rhabdoid Tumor Of The Cns
Rhabdoid Tumour Of The Cns	Familial Posterior Fossa Brain Tumor Syndrome
Hereditary Swi/Snf Deficiency Syndrome	Atrt

Infratentorial Cancer

Infratentorial Neoplasms	Brain Neoplasm, Infratentorial
Malignant Infratentorial Tumors

Spinal Cord Disease

Spinal Cord Diseases	Myelopathy
Bone Marrow Diseases

Anaplastic Oligodendroglioma

Anaplastic Astrocytoma

Grade Iii Astrocytoma	Astrocytoma, Anaplastic
Grade Iii Astrocytic Tumor

Alpha-Thalassemia

Alpha Thalassemia	Alpha Thalassaemia
Alpha Plus Thalassemia	Thalassemia, Alpha-
Thalassemias, Alpha-	A-Thalassemia
Α-Thalassemia	A-THAL
Thalassemia	Alpha Thalassaemia Syndrome

Giant Cell Glioblastoma

Monstrocellular Sarcoma