H3C2 - H3 clustered histone 2 Gene

Also Known as H3/l; H3C1; H3C3; H3C4; H3C6; H3C7; H3C8; H3FL; H3C10; H3C11; H3C12; HIST1H3B

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8358

About H3C2

Cytogenetic location: 6p22.2 Genomic coordinates (GRCh38): 6:26,031,589-26,032,099 (from NCBI)

This gene has 1 transcript (splice variant), 80 orthologues, 20 paralogues and is associated with 53 phenotypes.

Summary

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]

H3C2 Products (1)

mRNA Protein Name
NM_003537.4 NP_003528.1 histone H3.1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IDA
IDA: Inferred from direct assay
30867594 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10949293 GOA
Biological Process GO Annotation Evidence References Source
involved in epigenetic regulation of gene expression IDA
IDA: Inferred from direct assay
16267050 GOA
acts upstream of positive effect gene expression IDA
IDA: Inferred from direct assay
30867594 GOA
involved in nucleosome assembly IDA
IDA: Inferred from direct assay
14718166 GOA
involved in nucleosome assembly IMP
IMP: Inferred from mutant phenotype
25615412 GOA
Cellular Component GO Annotation Evidence References Source
part of nucleosome IDA
IDA: Inferred from direct assay
14718166 GOA
part of nucleosome IPI
IPI: Inferred from physical interaction
21812398 GOA
located in nucleus IDA
IDA: Inferred from direct assay
21636898 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
14718166 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

H3C2 Protein Structure

Histone

Histone: Core histone H2A/H2B/H3/H4 (58 - 132)

  • 0
  • 100
  • 136 a.a.
Protein Preferred Names Protein Names

histone H3.1

  • H3 histone family, member L

Recombinant H3C2 Proteins

Cat. No. Product Name Accession Purity
HY-P72332 Histone H3 Protein, Human P68431 (A2-A136) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P72335 Histone H3 Protein, Human (98a.a, His) P68431 (P39-A136) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P72798 Histone H3 Protein, Human (His) P68431 (A2-A136) ≥ 90%, as determined by reducing SDS-PAGE.

H3C2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P80166 Histone H3 Antibody (YA368) WB, ICC/IF, IHC-P, IP, ChIP Human, Mouse, Rat
HY-P85644 Histone H3 Antibody(HRP) (YA5336) WB Zebrafish
HY-P85652 Histone H3 Antibody (YA5344) WB, ICC/IF, ELISA Human, Mouse, Rat
HY-P85670 Histone H3 (Di Methyl Lys79) Antibody (YA5362) WB Human, Mouse, Rat
HY-P85671 Histone H3 (Tri Methyl Lys36) Antibody (YA5363) WB, IP Human, Mouse, Rat
HY-P86071 Histone H3 (Tri Methyl Lys36) Antibody (YA5763) WB, IHC-P, ICC/IF, IP, ELISA Human, Mouse, Rat
HY-P86113 Histone H3 (Di Methyl Lys4) Antibody (YA5805) WB, IHC-P, ICC/IF, IP, ELISA Human, Mouse, Rat
HY-P86144 Histone H3 (Acetyl Lys36) Antibody (YA5836) WB, IHC-P, ICC/IF, IP, ChIP, ELISA Human, Mouse, Rat
HY-P86148 Histone H3 (Di Methyl Lys9) Antibody (YA5840) WB, IHC-P, ICC/IF, IP, ChIP, ELISA Human, Mouse, Rat

Related Diseases

Diseases Alias
Hematologic Cancer

  • Hematologic Neoplasm

  • Hematologic Neoplasms

  • Hematologic Malignancies

  • Blood Cancer

  • Hematologic Malignancy

  • Hematological Tumors

  • Hematopoietic And Lymphoid System Tumor

  • Hematopoietic Cancer

  • Hematopoietic Neoplasm

  • Hematopoietic Tumors

  • Malignant Hematopoietic Neoplasm

  • Liquid Tumor

  • Hematopoietic Neoplasms
Histone Mutated Tumor

  • Histone Mutated Tumour
Diffuse Midline Glioma, H3 K27m-Mutant

  • Diffuse Intrinsic Pontine Glioma

  • Dipg

  • Infiltrative Brainstem Glioma
Brain Stem Cancer

  • Brain Stem Neoplasms

  • Malignant Neoplasm Of Brain Stem

  • Malignant Neoplasm Of Brainstem

  • Neoplasm Of Adult Brain Stem

  • Neoplasm Of Brain Stem

  • Primary Brain Stem Neoplasm

  • Primary Brain Stem Tumor

  • Brain Stem Neoplasm

  • Brain Stem--Cancer

  • Brain Stem Neoplasms, Primary
Adult Infiltrating Astrocytic Neoplasm

  • Adult Infiltrating Astrocytoma

  • Adult Infiltrating Astrocytic Tumor
Hutchinson-Gilford Progeria Syndrome

  • Progeria

  • HGPS

  • Hutchinson-Gilford Syndrome

  • Hutchinson-Gilford Progeria

  • Hutchinson Gilford Syndrome

  • Hutchinson Gilford Progeria Syndrome

  • Hutchinson-Gilford Disease

  • Progeria Of Childhood

  • Hutchinson-Gilford-Progeria Syndrome
Brain Stem Glioma

  • Brainstem Glioma

  • Brainstem Neuroglial Tumor

  • Glioma Of Brainstem
Posterior Fossa Ependymoma
Childhood Brain Stem Glioma

  • Pediatric Glioma Of The Brainstem
Idh-Wildtype Glioblastoma
High Grade Ependymoma

  • Ependymal Neoplasm

  • Ependymal Tumors

  • Malignant Ependymoma

  • Ependymal Tumor

  • Anaplastic Ependymoma

  • Experimental Organism Malignant Ependymoma

  • Ependymoma Of Brain
Adult Astrocytic Tumour

  • Adult Astrocytoma

  • Adult Astrocytic Tumors
Diffuse Astrocytoma

  • Diffuse Astrocytoma, Low Grade

  • Who Grade Ii Astrocytoma

  • Fibrillary Astrocytoma

  • Gemistocytic Astrocytoma

  • Low-Grade Diffuse Astrocytoma

  • Protoplasmic Astrocytoma
Rela Fusion-Positive Ependymoma

  • Supratentorial C11orf95-Rela Fused Ependymoma

  • C11orf95 Fusion-Positive Supratentorial Ependymoma
Pilomyxoid Astrocytoma
Anaplastic Oligodendroglioma
Low Grade Glioma

  • Benign Glioma
Pilocytic Astrocytoma

  • Juvenile Pilocytic Astrocytoma

  • Grade I Astrocytic Tumor

  • Piloid Astrocytoma
Central Nervous System Benign Neoplasm

  • Benign Neoplasm Of The Central Nervous System
Anaplastic Astrocytoma

  • Grade Iii Astrocytoma

  • Astrocytoma, Anaplastic

  • Grade Iii Astrocytic Tumor
Atypical Teratoid Rhabdoid Tumor

  • Rhabdoid Tumor Predisposition Syndrome

  • Rtps

  • Atypical Teratoid/Rhabdoid Tumor

  • Rhabdoid Predisposition Syndrome

  • Familial Posterior Fossa Brain Tumor Of Infancy

  • Familial Rhabdoid Tumor

  • At/Rt

  • Atypical Teratoid Rhabdoid Tumour

  • Atypical Teratoid/Rhabdoid Tumour

  • Rhabdoid Tumor Of The Cns

  • Rhabdoid Tumour Of The Cns

  • Familial Posterior Fossa Brain Tumor Syndrome

  • Hereditary Swi/Snf Deficiency Syndrome

  • Atrt
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05966 H3C1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05968 H3C2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05969 H3C3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05970 H3C6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05971 H3C7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05972 H3C8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus H3C2 MGD MGI:2448319