CASP6 - caspase 6 Gene

Also Known as Mch2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 83584

About CASP6

Primary_assembly 2: 218,466,076-218,478,502 forward strand.mRatBN7.2:CM026975.1

This gene has 1 transcript (splice variant), 268 orthologues, 12 paralogues and is associated with 16 phenotypes. Biased expression in Thymus (RPKM 132.6), Liver (RPKM 128.) and 9 other tissues.

Summary

Enables endopeptidase activity. Involved in several processes, including acute inflammatory response to non-antigenic stimulus; axonal fasciculation; and positive regulation of programmed cell death. Located in several cellular components, including axon; cytosol; and neuronal cell body. Used to study status epilepticus. Biomarker of brain ischemia; endometritis; middle cerebral artery infarction; and prostate carcinoma. Human ortholog(s) of this gene implicated in ovarian carcinoma. Orthologous to human CASP6 (Caspase 6). [provided by Alliance of Genome Resources, Apr 2022]

CASP6 Products (2)

mRNA Protein Name
NM_001271984.1 NP_001258913.1 caspase-6
NM_031775.3 NP_113963.2 caspase-6

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables endopeptidase activity IDA
IDA: Inferred from direct assay
12081569 RGD
Biological Process GO Annotation Evidence References Source
involved in acute inflammatory response to non-antigenic stimulus IDA
IDA: Inferred from direct assay
18175566 RGD
involved in axonal fasciculation IMP
IMP: Inferred from mutant phenotype
25898930 RGD
involved in lens development in camera-type eye IEP
IEP: Inferred from expression pattern
15161922 RGD
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
12606487 RGD
involved in positive regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
11433428 RGD
involved in positive regulation of retinal cell programmed cell death IMP
IMP: Inferred from mutant phenotype
12917395 RGD
involved in response to cytokine IDA
IDA: Inferred from direct assay
15201138 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
12967350 RGD
involved in response to gamma radiation IEP
IEP: Inferred from expression pattern
10590178 RGD
involved in response to glucose IMP
IMP: Inferred from mutant phenotype
12606487 RGD
involved in response to hydrogen peroxide IDA
IDA: Inferred from direct assay
17571084 RGD
involved in response to iron ion IMP
IMP: Inferred from mutant phenotype
17571084 RGD
involved in response to metal ion IEP
IEP: Inferred from expression pattern
11960910 RGD
involved in response to testosterone IEP
IEP: Inferred from expression pattern
12724284 RGD
involved in response to toxic substance IEP
IEP: Inferred from expression pattern
16733813 RGD
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
25898930 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
25898930 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CASP6 Protein Structure

CASc

CASc: smart00115 (19 - 272)

  • 0
  • 100
  • 200
  • 277 a.a.
Protein Preferred Names Protein Names

caspase-6

  • CASP-6

  • apoptotic protease Mch-2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-125194 NWL-117 Inhibitor / Unkown
HY-RS01959 CASP6 Human Pre-designed siRNA Set A / Unkown
HY-RS01960 Casp6 Mouse Pre-designed siRNA Set A / Unkown
HY-RS01961 CASP6 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens CASP6 NCBI NCBI:839