Nefl - neurofilament light chain Gene

Also Known as Nfl; NF-L; NF68

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 83613

Summary

Enables Phospholipase binding activity and protein domain specific binding activity. Involved in several processes, including central nervous system development; intermediate filament Cytoskeleton organization; and response to corticosterone. Located in growth cone and neurofilament. Colocalizes with neuron projection. Used to study congenital hypothyroidism. Biomarker of hypothyroidism; mental depression; sciatic neuropathy; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease (multiple); amyotrophic lateral sclerosis; and invasive ductal carcinoma. Orthologous to human NEFL (neurofilament light chain). [provided by Alliance of Genome Resources, Apr 2022]

Nefl Products (1)

mRNA Protein Name
NM_031783.2 NP_113971.1 neurofilament light polypeptide

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables phospholipase binding IPI
IPI: Inferred from physical interaction
16819285 RGD
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
16819285 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
9388258 RGD
Biological Process GO Annotation Evidence References Source
involved in cerebral cortex development IEP
IEP: Inferred from expression pattern
10439464 RGD
involved in hippocampus development IEP
IEP: Inferred from expression pattern
14620872 RGD
involved in intermediate filament polymerization or depolymerization IDA
IDA: Inferred from direct assay
10362553 RGD
involved in neurofilament bundle assembly IDA
IDA: Inferred from direct assay
7721944 RGD
involved in protein polymerization IDA
IDA: Inferred from direct assay
17157386 RGD
involved in response to acrylamide IEP
IEP: Inferred from expression pattern
17043767 RGD
involved in response to corticosterone IEP
IEP: Inferred from expression pattern
17229084 RGD
involved in response to peptide hormone IEP
IEP: Inferred from expression pattern
18157692 RGD
involved in response to sodium arsenite IDA
IDA: Inferred from direct assay
18674524 RGD
involved in response to toxic substance IEP
IEP: Inferred from expression pattern
18001836 RGD
involved in spinal cord development IEP
IEP: Inferred from expression pattern
2108255 RGD
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
8737171 RGD
located in growth cone IDA
IDA: Inferred from direct assay
12226091 RGD
located in neurofilament IDA
IDA: Inferred from direct assay
7721944 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neurofilament light polypeptide

  • 68 kDa neurofilament protein

  • 68kDa neurofilament

  • neurofilament triplet L protein

  • neurofilament, light polypeptide

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09184 NEFL Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17540 Nefl Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23998 Nefl Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nefl NCBI NCBI:4747