2. Gene
  3. Plk2 - polo-like kinase 2 Gene

Plk2 - polo-like kinase 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Snk

Gene ID: 83722 | Gene type: protein coding

About Plk2

Primary_assembly 2: 41,969,176-41,974,947 forward strand.mRatBN7.2:CM026975.1

This gene has 2 transcripts (splice variants), 221 orthologues, 4 paralogues and is associated with 8 phenotypes. Biased expression in Brain (RPKM 389.), Liver (RPKM 239.2) and 9 other tissues.

Summary

Enables protein serine/threonine kinase activity. Involved in several processes, including Rap protein signal transduction; negative regulation of dendritic spine development; and regulation of synaptic plasticity. Located in dendrite. Orthologous to human PLK2 (polo like kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Plk2 Products(1)

mRNA Protein Name
NM_031821.2 NP_114009.1 serine/threonine-protein kinase PLK2

Plk2 Protein Structure

STKc_PLK2

STKc_PLK2: cd14188 (76 - 330)

POLO_box_1

POLO_box_1: cd13118 (499 - 584)

POLO_box_2

POLO_box_2: cd13117 (597 - 678)

  • 0
  • 200
  • 400
  • 600
  • 682 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase PLK2

PLK-2

polo-like kinase 1

serine/threonine-protein kinase SNK

serum-inducible kinase

Related Agents

Approval
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12137 Volasertib Inhibitor 99.41% Yes
HY-12137A Volasertib trihydrochloride Inhibitor / Unkown
Clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Phase
HY-12037A Rigosertib Inhibitor 98.35% Phase 3
HY-12037 Rigosertib sodium Inhibitor 99.57% Phase 3
HY-50698 BI 2536 Inhibitor 99.95% Phase 2
HY-147298 Plogosertib Inhibitor 99.95% Phase 2
HY-15160 TAK-960 Inhibitor 99.75% Phase 1
HY-15160B TAK-960 dihydrochloride Inhibitor 99.19% Phase 1
HY-15160A TAK-960 hydrochloride Inhibitor / Phase 1
Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-108597 TC-S 7005 Inhibitor 99.56% Unkown
HY-12134 Poloxin Inhibitor 98.01% Unkown
HY-149100 PLK1-IN-6 Inhibitor / Unkown
HY-115589 YLT-11 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Plk2 NCBI NCBI:10769