Lgals3 - galectin 3 Gene

Also Known as L-34; CBP30; gal-3; AGE-R3

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 83781

Summary

Enables several functions, including Fc-gamma Receptor I complex binding activity; IgE binding activity; and advanced glycation end-product receptor activity. Involved in several processes, including negative regulation of cell proliferation in bone marrow; positive regulation of angiogenesis; and positive regulation of serotonin secretion. Located in several cellular components, including cell surface; extracellular space; and nucleus. Biomarker of several diseases, including acute kidney failure; attention deficit hyperactivity disorder; brain ischemia; congestive heart failure; and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in asthma. Orthologous to human LGALS3 (Galectin 3). [provided by Alliance of Genome Resources, Apr 2022]

Lgals3 Products (1)

mRNA Protein Name
NM_031832.1 NP_114020.1 galectin-3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables Fc-gamma receptor I complex binding IDA
IDA: Inferred from direct assay
8347574 RGD
enables IgE binding IDA
IDA: Inferred from direct assay
2249984 RGD
enables advanced glycation end-product receptor activity IDA
IDA: Inferred from direct assay
8529130 RGD
enables disaccharide binding IDA
IDA: Inferred from direct assay
2249984 RGD
enables monosaccharide binding IDA
IDA: Inferred from direct assay
2249984 RGD
Biological Process GO Annotation Evidence References Source
involved in negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
16600178 RGD
involved in negative regulation of cell proliferation in bone marrow IDA
IDA: Inferred from direct assay
9241534 RGD
involved in positive regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
19573520 RGD
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
19573520 RGD
involved in positive regulation of serotonin secretion IDA
IDA: Inferred from direct assay
8347574 RGD
involved in response to quercetin IEP
IEP: Inferred from expression pattern
28032729 RGD
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
9241534 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
9241534 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

galectin-3

  • 35 kDa lectin

  • CBP 35

  • IgE binding protein

  • carbohydrate-binding protein 35

  • epsilon BP

  • galactose-specific lectin 3

  • igE-binding protein

  • laminin-binding protein

  • lectin L-29

  • lectin galactoside-binding soluble 3 protein

  • lectin, galactose binding, solub

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07604 LGALS3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07605 LGALS3BP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16882 Lgals3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19847 Lgals3bp Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23324 Lgals3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26345 Lgals3bp Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992257 Anti-LGALS3BP Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lgals3 NCBI NCBI:3958