STK40 - serine/threonine kinase 40 Gene

Also Known as SHIK; SgK495

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 83931

About STK40

Cytogenetic location: 1p34.3 Genomic coordinates (GRCh38): 1:36,339,628-36,385,924 (from NCBI)

This gene has 8 transcripts (splice variants), 206 orthologues and 3 paralogues. Ubiquitous expression in testis (RPKM 28.4), ovary (RPKM 17.2) and 25 other tissues.

Summary

Predicted to enable ATP binding activity; protein serine kinase activity; and protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation. Predicted to act upstream of or within several processes, including glycogen metabolic process; lung development; and respiratory system process. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

STK40 Products (3)

mRNA	Protein	Name
NM_001282546.2	NP_001269475.1	serine/threonine-protein kinase 40 isoform 1
NM_001282547.2	NP_001269476.1	serine/threonine-protein kinase 40 isoform 2
NM_032017.3	NP_114406.1	serine/threonine-protein kinase 40 isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21784977	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STK40 Protein Structure

Pkinase

0
100
200
300
400
435 a.a.

Protein Preferred Names	Protein Names
serine/threonine-protein kinase 40	SINK-homologous serine/threonine-protein kinase

STK40 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	STK40	Q8N2I9	SLIRP	Homo sapiens	Q9GZT3	Validated Y2H	32296183
Intra	STK40	Q8N2I9	TRIB1	Homo sapiens	Q96RU8	Anti Tag CoIP	25852190
Intra	STK40	Q8N2I9	TRIB1	Homo sapiens	Q96RU8	Anti Tag CoIP	33961781
Intra	STK40	Q8N2I9	TRIB1	Homo sapiens	Q96RU8	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant STK40 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76098	STK40 Protein, Human (sf9, His-GST)	Q8N2I9-1 (M1-K435)	≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Hypomelanosis Of Ito	Incontinentia Pigmenti Achromians Nevus Of Ito Ipa Ito Hypomelanosis Ito Pigmentation Disorders HMI Incontinentia Pigmenti, Type I, Formerly Ip1, Formerly Bloch-Siemans Syndrome Incontinentia Pigmenti Achromians Syndrome Ito'S Nevus Incontinentia Pigmenti Type 1 Nevi Of Ito Nevus Fuscocaeruleus Acromiodeltoideus Bloch Sulzberger Syndrome Skin Pigmentation Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13942	STK40 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19744	Stk40 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26241	Stk40 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	STK40	VGNC	VGNC:46923
Rattus norvegicus	STK40	RGD	RGD:727884
Bos taurus	STK40	VGNC	VGNC:35402
Macaca mulatta	STK40	VGNC	VGNC:78186
Felis catus	STK40	VGNC	VGNC:65788
Mus musculus	STK40	MGD	MGI:1921428
Others	STK40	NCBI