Il12a - interleukin 12A Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 84405

About Il12a

Primary_assembly 2: 152,965,769-152,972,734 forward strand.mRatBN7.2:CM026975.1

This gene has 2 transcripts (splice variants), 234 orthologues and is associated with 13 phenotypes. Biased expression in Thymus (RPKM 41.7), Uterus (RPKM 24.6) and 6 other tissues.

Summary

Predicted to enable interleukin-12 beta subunit binding activity; interleukin-27 binding activity; and protein heterodimerization activity. Predicted to contribute to cytokine activity and growth factor activity. Involved in response to granulocyte colony-stimulating factor. Predicted to be located in cell surface; cytoplasm; and extracellular space. Predicted to be part of interleukin-12 complex. Human ortholog(s) of this gene implicated in hepatitis C; hepatocellular carcinoma; and primary biliary cholangitis. Orthologous to human IL12A (interleukin 12A). [provided by Alliance of Genome Resources, Apr 2022]

Il12a Products (1)

mRNA Protein Name
NM_053390.1 NP_445842.1 interleukin-12 subunit alpha precursor

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in response to granulocyte colony-stimulating factor IEP
IEP: Inferred from expression pattern
12668156 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Il12a Protein Structure

IL12

IL12: pfam03039 (16 - 214)

  • 0
  • 100
  • 200
  • 215 a.a.
Protein Preferred Names Protein Names

interleukin-12 subunit alpha

  • CLMF p35

  • IL-12 subunit p35

  • IL-12A

  • cytotoxic lymphocyte maturation factor 35 kDa subunit

  • interleukin 12 p35 subunit

Recombinant Il12a Proteins

Cat. No. Product Name Accession Purity
HY-P7370 IL-12 Protein, Rat (CHO) Q9R103 (R23-S215)&E9PU71 (M23-S335) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P72598 IL-12 Protein, Rat (HEK293, His) Q9R103 (R23-S215)&Q9R278 (M23-S335) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06677 IL12A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06678 Il12a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06679 Il12a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174642 Human IL12A mRNA / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Il12a NCBI NCBI:3592