IL12A - interleukin 12A Gene

Also Known as P35; CLMF; NFSK; NKSF1; IL-12A

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3592

About IL12A

Cytogenetic location: 3q25.33 Genomic coordinates (GRCh38): 3:159,988,835-159,996,019 (from NCBI)

This gene has 7 transcripts (splice variants), 233 orthologues and is associated with 2 phenotypes. Broad expression in esophagus (RPKM 2.2), lung (RPKM 1.4) and 19 other tissues.

Summary

This gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity. [provided by RefSeq, Jul 2008]

IL12A Products (4)

mRNA Protein Name
NM_001354582.2 NP_001341511.1 interleukin-12 subunit alpha isoform 2
NM_001397992.1 NP_001384921.1 interleukin-12 subunit alpha isoform 4 precursor
NM_001354583.2 NP_001341512.1 interleukin-12 subunit alpha isoform 3
NM_000882.4 NP_000873.2 interleukin-12 subunit alpha isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
contributes to cytokine activity IDA
IDA: Inferred from direct assay
1674604 GOA
enables cytokine activity IDA
IDA: Inferred from direct assay
7584494 GOA
contributes to growth factor activity IDA
IDA: Inferred from direct assay
1674604 GOA
enables interleukin-12 beta subunit binding IPI
IPI: Inferred from physical interaction
11023671 GOA
enables interleukin-27 binding IPI
IPI: Inferred from physical interaction
9342359 GOA
enables protein binding IDA
IDA: Inferred from direct assay
10899108 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
7527811 GOA
enables protein heterodimerization activity IPI
IPI: Inferred from physical interaction
1674604 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in cell migration IDA
IDA: Inferred from direct assay
7903063 GOA
involved in cellular response to virus IMP
IMP: Inferred from mutant phenotype
25754930 GOA
involved in defense response to Gram-positive bacterium IEP
IEP: Inferred from expression pattern
1357073 GOA
involved in extrinsic apoptotic signaling pathway IDA
IDA: Inferred from direct assay
16942485 GOA
involved in interleukin-12-mediated signaling pathway IDA
IDA: Inferred from direct assay
7584494 GOA
acts upstream of negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis IGI
IGI: Inferred from genetic interaction
30106099 GOA
involved in negative regulation of interleukin-17 production IDA
IDA: Inferred from direct assay
16482511 GOA
acts upstream of or within negative regulation of protein secretion IGI
IGI: Inferred from genetic interaction
30106099 GOA
involved in negative regulation of smooth muscle cell proliferation IDA
IDA: Inferred from direct assay
16942485 GOA
acts upstream of negative regulation of vascular endothelial growth factor signaling pathway IGI
IGI: Inferred from genetic interaction
30106099 GOA
involved in positive regulation of NK T cell activation IDA
IDA: Inferred from direct assay
19088061 GOA
involved in positive regulation of T cell mediated cytotoxicity IDA
IDA: Inferred from direct assay
1674604 GOA
involved in positive regulation of cell adhesion IDA
IDA: Inferred from direct assay
7903063 GOA
involved in positive regulation of dendritic cell chemotaxis IMP
IMP: Inferred from mutant phenotype
25754930 GOA
involved in positive regulation of lymphocyte proliferation IDA
IDA: Inferred from direct assay
1674604 GOA
involved in positive regulation of mononuclear cell proliferation IMP
IMP: Inferred from mutant phenotype
11023671 GOA
involved in positive regulation of natural killer cell activation IDA
IDA: Inferred from direct assay
1674604 GOA
involved in positive regulation of natural killer cell mediated cytotoxicity IDA
IDA: Inferred from direct assay
2204066 GOA
involved in positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target IDA
IDA: Inferred from direct assay
7903063 GOA
involved in positive regulation of smooth muscle cell apoptotic process IDA
IDA: Inferred from direct assay
16942485 GOA
involved in positive regulation of type II interferon production IDA
IDA: Inferred from direct assay
1674604 GOA
involved in positive regulation of tyrosine phosphorylation of STAT protein IDA
IDA: Inferred from direct assay
12372421 GOA
involved in response to UV-B IDA
IDA: Inferred from direct assay
8992506 GOA
involved in response to lipopolysaccharide IDA
IDA: Inferred from direct assay
7605994 GOA
involved in response to virus IEP
IEP: Inferred from expression pattern
16548883 GOA
Cellular Component GO Annotation Evidence Verweise Source
is active in extracellular space IDA
IDA: Inferred from direct assay
10899108 GOA
located in extracellular space IDA
IDA: Inferred from direct assay
16456693 GOA
part of interleukin-12 complex IDA
IDA: Inferred from direct assay
2204066 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IL12A Protein Structure

IL12

IL12: Interleukin-12 alpha subunit (35 - 253)

  • 0
  • 100
  • 200
  • 253 a.a.
Protein Preferred Names Protein Names

interleukin-12 subunit alpha

  • CLMF p35

  • IL-12, subunit p35

  • IL35 subunit

  • NF cell stimulatory factor chain 1

  • NK cell stimulatory factor chain 1

  • cytotoxic lymphocyte maturation factor 1, p35

  • cytotoxic lymphocyte maturation factor 35 kDa subunit

  • interleukin 12, p35

  • interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)

  • interleukin-12 alpha chain

IL12A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
IL12A P29459 IL12B Homo sapiens P29460
Comig Non-Denat Gel
7527811
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IL12A Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P7032 IL-12 Protein, Human (HEK293) P29459 (R23-S219)&P29460 (I23-S328) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P70338 IL-35 Protein, Human (HEK293, Fc) P29459 (R23-S219)&Q14213 (R21-K229) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P7032G GMP IL-12 Protein, Human (HEK293) P29459 (R23-S219)&P29460 (I23-S328) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P73156 GMP IL-12 Protein, Human (HEK293, His) P29459 (R23-S219)&P29460 (I23-S328) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P73880 IL-35 Protein, Human (HEK293, Flag-His) P29459 (R23-S219)&Q14213 (R21-K229) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P73882 IL-35 Protein, Human (HEK293, His, hFc-Flag) P29459 (R23-S219)&Q14213 (R21-K229) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P73898 IL-12 Protein, Human (HEK293, His) P29459 (R23-S219)&P29460 (I23-S328) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P77511 IL-12 Protein, Human (Biotinylated, HEK293, His) P29459 (R23-S219)&P29460 (I23-S328) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P77702 IL-12 Protein, Human (Biotinylated, HEK293, His-Avi) P29459 (R23-S219)&P29460 (I23-S328) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P700099AF Animal-Free IL-12 alpha Protein, Human (His) P29459 (R23-S219) ≥ 95%, as determined by reducing SDS-PAGE.

IL12A Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P811069 IL-12A Antibody WB, IHC-P Human, Bovine

Related Diseases

Diseases Alias
Inflammatory Bowel Disease

  • Inflammatory Bowel Diseases

  • Bowel Disease, Inflammatory
Behcet Syndrome

  • Behcet Disease

  • Behcet'S Syndrome

  • Behcet'S Disease

  • Behçet Disease

  • Bd

  • Adamantiades-Behcet Disease

  • Triple Symptom Complex

  • Behet'S Syndrome

  • Bd Syndrome

  • Behçet Syndrome

  • Behçet'S Disease

  • Behçet'S Syndrome

  • Behcet Triple Symptom Complex

  • Malignant Aphthosis

  • Old Silk Route Disease

  • Adamantiades-Behçet Disease
Primary Biliary Cholangitis

  • Primary Biliary Cirrhosis

  • Biliary Liver Cirrhosis

  • Chronic Nonsuppurative Destructive Cholangitis

  • Familial Primary Biliary Cirrhosis

  • Pbc

  • Hanot Syndrome

  • Cholestatic Cirrhosis

  • Biliary Cirrhosis Primary

  • Liver Cirrhosis, Biliary

  • Hanot'S Cirrhosis

  • Biliary Cirrhosis

  • Pericholangiolic Biliary Cirrhosis

  • Tannhauser-Magendantz Syndrome

  • Hanot-Rossle Syndrome

  • Hypertrophic Cirrhosis

  • Todd Cirrhosis

  • Hanot Cirrhosis

  • Charcot Cirrhosis

  • Mahon-Tannhauser Syndrome

  • Toxic Cirrhosis

  • Hypertrophic Biliary Cirrhosis

  • Monolobular Cirrhosis

  • Unilobar Cirrhosis

  • Xanthomatous Biliary Cirrhosis
Properdin Deficiency, X-Linked

  • Properdin Deficiency

  • PFD

  • CFPD

  • Properdin P Factor Deficiency

  • Complement Factor Properdin Deficiency

  • X-Linked Properdin Deficiency

  • Properdin Deficiency, Type I

  • Properdin Deficiency, Type 1

  • Properdin Deficiency Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS06677 IL12A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06678 Il12a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06679 Il12a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174642 Human IL12A mRNA / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus IL12A RGD RGD:620562
Mus musculus IL12A MGD MGI:96539
Canis familiaris IL12A VGNC VGNC:41932
Bos taurus IL12A VGNC VGNC:30110
Felis catus IL12A VGNC VGNC:102761
Macaca mulatta IL12A VGNC VGNC:84168
Others IL12A NCBI