1. Gene
  2. IL12A - interleukin 12A Gene

IL12A - interleukin 12A Gene

Homo sapiens

Also known as P35; CLMF; NFSK; NKSF1; IL-12A

Gene ID: 3592 | Gene type: protein coding

About IL12A

Cytogenetic location: 3q25.33 Genomic coordinates (GRCh38): 3:159,988,835-159,996,019 (from NCBI)

This gene has 7 transcripts (splice variants), 233 orthologues and is associated with 2 phenotypes. Broad expression in esophagus (RPKM 2.2), lung (RPKM 1.4) and 19 other tissues.

Summary

This gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity. [provided by RefSeq, Jul 2008]

IL12A Products(4)

mRNA Protein Name
NM_001354582.2 NP_001341511.1 interleukin-12 subunit alpha isoform 2
NM_001397992.1 NP_001384921.1 interleukin-12 subunit alpha isoform 4 precursor
NM_001354583.2 NP_001341512.1 interleukin-12 subunit alpha isoform 3
NM_000882.4 NP_000873.2 interleukin-12 subunit alpha isoform 1 precursor

IL12A Protein Structure

IL12

IL12: Interleukin-12 alpha subunit (35 - 253)

  • 0
  • 100
  • 200
  • 253 a.a.
Protein Preferred Names Protein Names

interleukin-12 subunit alpha

CLMF p35

IL-12, subunit p35

IL35 subunit

NF cell stimulatory factor chain 1

NK cell stimulatory factor chain 1

cytotoxic lymphocyte maturation factor 1, p35

cytotoxic lymphocyte maturation factor 35 kDa subunit

interleukin 12, p35

interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)

interleukin-12 alpha chain

Recombinant IL12A Proteins

Cat. No. Product Name Accession Purity
HY-P7032 IL-12 Protein, Human (HEK293) P29459 (R23-S219) & P29460 (I23-S328) ≥95%
HY-P70338 IL-35 Protein, Human (HEK293, Fc) P29459 (R23-S219)&Q14213 (R21-K229) ≥95%
HY-P7032G GMP IL-12 Protein, Human (HEK293) P29459 (R23-S219) & P29460 (I23-S328) ≥95%
HY-P73156 GMP IL-12 Protein, Human (HEK293, His) P29459 (R23-S219) & P29460 (I23-S328) ≥95%
HY-P73880 IL-35 Protein, Human (HEK293, Flag-His) P29459 (R23-S219)&Q14213 (R21-K229) ≥95%
HY-P73881 IL-35 Protein, Human (full length, HEK293, Fc) P29459 (M1-S219)&Q14213 (M1-K229) ≥95%
HY-P73882 IL-35 Protein, Human (HEK293, His-hFc-Myc) P29459 (R23-S219)&Q14213 (R21-K229) ≥95%
HY-P73898 IL-12 Protein, Human (HEK293, His) P29459 (R23-S219) & P29460 (I23-S328) ≥95%
HY-P73899 IL-12 Protein, Human (547a.a, HEK293) P29459 (M1-S219)&P29460 (M1-S328) ≥95%
HY-P77511 IL-12 Protein, Human (Biotinylated, HEK293, His) P29459 (R23-S219) & P29460 (I23-S328) ≥95%
HY-P77702 IL-12 Protein, Human (Biotinylated, HEK293, His-Avi) P29459 (R23-S219) & P29460 (I23-S328) ≥95%
HY-P700099AF Animal-Free IL-12 alpha Protein, Human (His) P29459 (R23-S219) ≥95%

Related Diseases

Diseases Alias
Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Behcet Syndrome

Behcet Disease

Behcet'S Syndrome

Behcet'S Disease

Behçet Disease

Bd

Adamantiades-Behcet Disease

Triple Symptom Complex

Behet'S Syndrome

Bd Syndrome

Behçet Syndrome

Behçet'S Disease

Behçet'S Syndrome

Behcet Triple Symptom Complex

Malignant Aphthosis

Old Silk Route Disease

Adamantiades-Behçet Disease

Primary Biliary Cholangitis

Primary Biliary Cirrhosis

Biliary Liver Cirrhosis

Chronic Nonsuppurative Destructive Cholangitis

Familial Primary Biliary Cirrhosis

Pbc

Hanot Syndrome

Cholestatic Cirrhosis

Biliary Cirrhosis Primary

Liver Cirrhosis, Biliary

Hanot'S Cirrhosis

Biliary Cirrhosis

Pericholangiolic Biliary Cirrhosis

Tannhauser-Magendantz Syndrome

Hanot-Rossle Syndrome

Hypertrophic Cirrhosis

Todd Cirrhosis

Hanot Cirrhosis

Charcot Cirrhosis

Mahon-Tannhauser Syndrome

Toxic Cirrhosis

Hypertrophic Biliary Cirrhosis

Monolobular Cirrhosis

Unilobar Cirrhosis

Xanthomatous Biliary Cirrhosis

Properdin Deficiency, X-Linked

Properdin Deficiency

PFD

CFPD

Properdin P Factor Deficiency

Complement Factor Properdin Deficiency

X-Linked Properdin Deficiency

Properdin Deficiency, Type I

Properdin Deficiency, Type 1

Properdin Deficiency Disease

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Rattus norvegicus IL12A RGD RGD:620562
Mus musculus IL12A MGD MGI:96539
Canis familiaris IL12A VGNC VGNC:41932
Bos taurus IL12A VGNC VGNC:30110
Felis catus IL12A VGNC VGNC:102761
Macaca mulatta IL12A VGNC VGNC:84168
Macaca fascicularis IL12A NCBI NCBI:102115316
Others IL12A NCBI