country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Fgfr3 - fibroblast growth factor receptor 3 Gene

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 84489

About Fgfr3

Primary_assembly 14: 76,987,993-77,003,341 reverse strand.mRatBN7.2:CM026987.1

This gene has 3 transcripts (splice variants), 191 orthologues, 54 paralogues and is associated with 74 phenotypes. Biased expression in Lung (RPKM 455.3), Brain (RPKM 133.8) and 5 other tissues.

Summary

Enables Fibroblast Growth Factor binding activity and fibroblast growth factor-activated receptor activity. Involved in cell-cell signaling; Fibroblast Growth Factor receptor signaling pathway; and positive regulation of cell population proliferation. Located in cell surface; cytoplasm; and nucleus. Biomarker of chondrosarcoma. Human ortholog(s) of this gene implicated in several diseases, including Crouzon syndrome-acanthosis nigricans syndrome; LADD syndrome; SADDAN; bone development disease (multiple); and carcinoma (multiple). Orthologous to human FGFR3 (Fibroblast Growth Factor receptor 3). [provided by Alliance of Genome Resources, Apr 2022]

Fgfr3 Products (1)

mRNA	Protein	Name
NM_053429.2	NP_445881.2	fibroblast growth factor receptor 3 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables fibroblast growth factor binding	IPI IPI: Inferred from physical interaction	15231666	RGD
enables fibroblast growth factor receptor activity	IDA IDA: Inferred from direct assay	15231666	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in cell-cell signaling	IDA IDA: Inferred from direct assay	15231666	RGD
involved in fibroblast growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	15231666	RGD
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	15231666	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	15614790	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Fgfr3 Protein Structure

Ig_3

IgI_2_FGFR

IgI_3_FGFR

PTKc_FGFR3

0
200
400
600
804 a.a.

Protein Preferred Names	Protein Names
fibroblast growth factor receptor 3

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-174981	LC-MF-4	Degrader	98.05%	Unkown
HY-184598	CYB-5067	Degrader	/	Unkown
HY-181752	FGFR3-IN-12	Inhibitor	/	Unkown
HY-183780	FGFR-IN-27	Inhibitor	/	Unkown
HY-160013	FGFR-IN-12	Inhibitor	/	Unkown
HY-184250	FGFR-IN-28	Inhibitor	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991106	IMC-D11	Inhibitor	98.51%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Fgfr3	NCBI	NCBI:2261