Ran - RAN, member RAS oncogene family Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 84509

Summary

Enables several functions, including dynein intermediate chain binding activity; guanyl ribonucleotide binding activity; and importin-alpha family protein binding activity. Involved in several processes, including cellular response to mineralocorticoid stimulus; hippocampus development; and spermatid development. Located in several cellular components, including male germ cell nucleus; manchette; and sperm flagellum. Part of nuclear pore. Used to study sciatic neuropathy. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human RAN (RAN, member Ras oncogene family). [provided by Alliance of Genome Resources, Apr 2022]

Ran Products (1)

mRNA Protein Name
NM_053439.2 NP_445891.1 GTP-binding nuclear protein Ran

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GDP binding IDA
IDA: Inferred from direct assay
19505478 RGD
enables GTP binding IDA
IDA: Inferred from direct assay
19505478 RGD
enables dynein intermediate chain binding IDA
IDA: Inferred from direct assay
18667152 RGD
enables importin-alpha family protein binding IDA
IDA: Inferred from direct assay
18667152 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
8918934 RGD
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
19505478 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
9398662 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to mineralocorticoid stimulus IEP
IEP: Inferred from expression pattern
22811487 RGD
involved in hippocampus development IEP
IEP: Inferred from expression pattern
18493952 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
16003757 RGD
involved in spermatid development IEP
IEP: Inferred from expression pattern
12211070 RGD
Cellular Component GO Annotation Evidence References Source
located in male germ cell nucleus IDA
IDA: Inferred from direct assay
11870094 RGD
located in manchette IDA
IDA: Inferred from direct assay
12211070 RGD
part of nuclear pore IDA
IDA: Inferred from direct assay
9398662 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
19505478 RGD
located in sperm flagellum IDA
IDA: Inferred from direct assay
12211070 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

GTP-binding nuclear protein Ran

  • GTPase Ran

  • ras-like protein TC4

  • ras-related nuclear protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-173350 Ran-IN-1 99.89% Unkown
HY-W250191 Tergitol / Unkown
HY-W141374 CB096 98.72% Unkown
HY-120743 Triplin / Unkown
HY-125964 LLP-3 Inhibitor 98.13% Unkown
HY-RS11641 RAN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16834 Ran Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23276 Ran Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ran NCBI NCBI:5901