Hes7 - hes family bHLH transcription factor 7 Gene

Also Known as bHLHb37

Species: Mus musculus

Gene Type: protein coding
Gene ID: 84653

Summary

Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription, DNA-templated. Acts upstream of or within several processes, including negative regulation of transcription by RNA polymerase II; post-anal tail morphogenesis; and somitogenesis. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; retina; small intestine; unsegmented mesenchyme; and urinary system. Human ortholog(s) of this gene implicated in spondylocostal dysostosis. Orthologous to human HES7 (hes family bHLH transcription factor 7). [provided by Alliance of Genome Resources, Apr 2022]

Hes7 Products (2)

mRNA Protein Name
NM_001401507.1 NP_001388436.1 transcription factor HES-7 isoform 2
NM_033041.5 NP_149030.2 transcription factor HES-7 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
16342160 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within Notch signaling pathway IDA
IDA: Inferred from direct assay
11260262 MGI
acts upstream of or within negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
12783854 MGI
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
18775957 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
11260262 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
21750544 MGI
acts upstream of or within post-anal tail morphogenesis IMP
IMP: Inferred from mutant phenotype
11641270 MGI
acts upstream of or within rhythmic process IDA
IDA: Inferred from direct assay
11641270 MGI
acts upstream of or within rhythmic process IMP
IMP: Inferred from mutant phenotype
15170214 MGI
acts upstream of or within skeletal system development IMP
IMP: Inferred from mutant phenotype
11641270 MGI
acts upstream of or within somitogenesis IMP
IMP: Inferred from mutant phenotype
11641270 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transcription factor HES-7

  • bHLH factor Hes7

  • hairy and enhancer of split 7

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-125130 Hesperetin 7-O-glucoside Inhibitor 99.38% Unkown
HY-RS06140 HES7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22199 Hes7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28721 Hes7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hes7 NCBI NCBI:84667