GALR3 - galanin receptor 3 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8484

About GALR3

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:37,823,382-37,825,485 (from NCBI)

This gene has 1 transcript (splice variant), 97 orthologues and 16 paralogues. Low expression observed in reference dataset.

Summary

The neuropeptide Galanin modulates a variety of physiologic processes including cognition/memory, sensory/pain processing, hormone secretion, and feeding behavior. The human Galanin receptors are G protein-coupled receptors that functionally couple to their intracellular effector through distinct signaling pathways. GALR3 is found in many tissues and may be expressed as 1.4-, 2.4-, and 5-kb transcripts [provided by RefSeq, Jul 2008]

GALR3 Products (1)

mRNA Protein Name
NM_003614.2 NP_003605.1 galanin receptor type 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables galanin receptor activity IDA
IDA: Inferred from direct assay
9832121 GOA
enables peptide hormone binding IDA
IDA: Inferred from direct assay
24517231 GOA
enables peptide hormone binding IPI
IPI: Inferred from physical interaction
9832121 GOA
Biological Process GO Annotation Evidence References Source
involved in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IDA
IDA: Inferred from direct assay
9832121 GOA
involved in galanin-activated signaling pathway IDA
IDA: Inferred from direct assay
9832121 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
24517231 GOA
Cellular Component GO Annotation Evidence References Source
located in cilium IDA
IDA: Inferred from direct assay
28154160 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GALR3 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (34 - 291)

  • 0
  • 100
  • 200
  • 300
  • 368 a.a.
Protein Preferred Names Protein Names

galanin receptor type 3

  • GAL3-R

Related Diseases

Diseases Alias
Alzheimer Disease, Familial, 1

  • Alzheimer Disease

  • Alzheimer'S Disease

  • Presenile And Senile Dementia

  • AD1

  • Alzheimer Disease, Susceptibility To

  • Alzheimer Disease, Late-Onset, Susceptibility To

  • Alzheimer Disease 1, Familial

  • AD

  • Familial Alzheimer Disease

  • Alzheimer Disease, Late-Onset

  • Alzheimers Dementia

  • Alzheimer Dementia

  • Alzheimer Sclerosis

  • Alzheimer Syndrome

  • Alzheimer-Type Dementia

  • Dat

  • Primary Senile Degenerative Dementia

  • Sdat

  • Alzheimer Disease 1

  • Autosomal Dominant Alzheimer Disease

  • Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

  • Late Onset Alzheimer Disease

  • Alzheimers Disease

  • Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

  • Late-Onset Alzheimers Disease

  • Alzheimer'S Disease Pathway Kegg

  • Dementia Due To Alzheimer'S Disease

  • Alzheimer Disease Type 1

  • Alzheimers
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P1130 M871 Antagonist 99.98% Unkown
HY-P1135 M1145 Agonist 99.96% Unkown
HY-P1135A M1145 TFA Agonist / Unkown
HY-RS05266 GALR3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22523 Galr3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29044 Galr3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus GALR3 RGD RGD:2658
Bos taurus GALR3 VGNC VGNC:29241
Macaca mulatta GALR3 VGNC VGNC:107792
Canis familiaris GALR3 VGNC VGNC:41102
Mus musculus GALR3 MGD MGI:1329003
Others GALR3 NCBI