1. GPCR/G Protein
    Neuronal Signaling
  2. Neuropeptide Y Receptor
  3. M1145 TFA

M1145 TFA 

Cat. No.: HY-P1135A
Handling Instructions

M1145 TFA, a chimeric peptide, is a selective galanin receptor type 2 (GAL2) agonist, with a Ki of 6.55 nM. M1145 TFA shows more than 90-fold higher affinity for GAL2 over GAL1 (Ki=587 nM) and a 76-fold higher affinity over GalR3 (Ki=497 nM). M1145 TFA has an additive effect on the signal transduction of galanin.

For research use only. We do not sell to patients.

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M1145 TFA Chemical Structure

M1145 TFA Chemical Structure

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Description

M1145 TFA, a chimeric peptide, is a selective galanin receptor type 2 (GAL2) agonist, with a Ki of 6.55 nM. M1145 TFA shows more than 90-fold higher affinity for GAL2 over GAL1 (Ki=587 nM) and a 76-fold higher affinity over GalR3 (Ki=497 nM). M1145 TFA has an additive effect on the signal transduction of galanin[1].

In Vitro

M1145 TFA has an additive effect on the signal transduction of galanin, are concentrations of M1145 TFA of 0.1 μM and higher all give a maximum transduction. Signal transduction was examined by assessing the ability to stimulate inositol phosphates (IP) production in CHO cells expressing GalR2. Treatment with M1145 TFA, which stimulates IP production with an EC50 of 38 nM[1].

Molecular Weight

2888.25

Formula

C₁₃₀H₂₀₆F₃N₃₇O₃₄

Sequence

Arg-Gly-Arg-Gly-Asn-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-Val-Leu-Pro-Pro-Pro-Ala-Leu-Ala-Leu-Ala-NH2

Sequence Shortening

RGRGNWTLNSAGYLLGPVLPPPALALA-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

M1145M 1145M-1145Neuropeptide Y ReceptorNPY receptortransductionsignalCHOcellsadditiveselectiveInhibitorinhibitorinhibit

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M1145 TFA
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