2. GPCR/G Protein Neuronal Signaling
  3. Neuropeptide Y Receptor
  4. M1145

M1145, a chimeric peptide, is a selective galanin receptor type 2 (GAL2) agonist, with a Ki of 6.55 nM. M1145 shows more than 90-fold higher affinity for GAL2 over GAL1 (Ki=587 nM) and a 76-fold higher affinity over GalR3 (Ki=497 nM). M1145 has an additive effect on the signal transduction of galanin.

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M1145 Chemical Structure

M1145 Chemical Structure

CAS No. : 1172089-00-7

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Based on 1 publication(s) in Google Scholar

Other Forms of M1145:

M1145 Related Antibodies

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Description

M1145, a chimeric peptide, is a selective galanin receptor type 2 (GAL2) agonist, with a Ki of 6.55 nM. M1145 shows more than 90-fold higher affinity for GAL2 over GAL1 (Ki=587 nM) and a 76-fold higher affinity over GalR3 (Ki=497 nM). M1145 has an additive effect on the signal transduction of galanin[1].

In Vitro

M1145 has an additive effect on the signal transduction of galanin, are concentrations of M1145 of 0.1 μM and higher all give a maximum transduction. Signal transduction was examined by assessing the ability to stimulate inositol phosphates (IP) production in CHO cells expressing GalR2. Treatment with M1145, which stimulates IP production with an EC50 of 38 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

M1145 Related Antibodies
Molecular Weight

2774.23

Formula

C128H205N37O32
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Arg-Gly-Arg-Gly-Asn-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-Val-Leu-Pro-Pro-Pro-Ala-Leu-Ala-Leu-Ala-NH2
Sequence Shortening

RGRGNWTLNSAGYLLGPVLPPPALALA-NH2
SMILES

[RGRGNWTLNSAGYLLGPVLPPPALALA-NH2]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Purity & Documentation
References
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M1145 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

M11451172089-00-7M 1145M-1145Neuropeptide Y ReceptorNPY receptortransductionsignalCHOcellsadditiveselectiveInhibitorinhibitorinhibit

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