2. GPCR/G Protein
    Neuronal Signaling
  3. Neuropeptide Y Receptor
  4. M1145

M1145 

Cat. No.: HY-P1135
Handling Instructions

M1145, a chimeric peptide, is a selective galanin receptor type 2 (GAL2) agonist, with a Ki of 6.55 nM. M1145 shows more than 90-fold higher affinity for GAL2 over GAL1 (Ki=587 nM) and a 76-fold higher affinity over GalR3 (Ki=497 nM). M1145 has an additive effect on the signal transduction of galanin.

For research use only. We do not sell to patients.

M1145 Chemical Structure

M1145 Chemical Structure

CAS No. : 1172089-00-7

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Description

M1145, a chimeric peptide, is a selective galanin receptor type 2 (GAL2) agonist, with a Ki of 6.55 nM. M1145 shows more than 90-fold higher affinity for GAL2 over GAL1 (Ki=587 nM) and a 76-fold higher affinity over GalR3 (Ki=497 nM). M1145 has an additive effect on the signal transduction of galanin[1].

In Vitro

M1145 has an additive effect on the signal transduction of galanin, are concentrations of M1145 of 0.1 μM and higher all give a maximum transduction. Signal transduction was examined by assessing the ability to stimulate inositol phosphates (IP) production in CHO cells expressing GalR2. Treatment with M1145, which stimulates IP production with an EC50 of 38 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

2774.23

Formula

C128H205N37O32
CAS No.
Sequence

Arg-Gly-Arg-Gly-Asn-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-Val-Leu-Pro-Pro-Pro-Ala-Leu-Ala-Leu-Ala-NH2
Sequence Shortening

RGRGNWTLNSAGYLLGPVLPPPALALA-NH2
SMILES

[RGRGNWTLNSAGYLLGPVLPPPALALA-NH2]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

M11451172089-00-7M 1145M-1145Neuropeptide Y ReceptorNPY receptortransductionsignalCHOcellsadditiveselectiveInhibitorinhibitorinhibit

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