MASTL - microtubule associated serine/threonine kinase like Gene

Also Known as GW; GWL; THC2; MAST-L; GREATWALL

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 84930

About MASTL

Cytogenetic location: 10p12.1 Genomic coordinates (GRCh38): 10:27,154,479-27,187,953 (from NCBI)

This gene has 4 transcripts (splice variants), 208 orthologues, 13 paralogues and is associated with 1 phenotype. Ubiquitous expression in bone marrow (RPKM 4.9), testis (RPKM 3.4) and 25 other tissues.

Summary

This gene encodes a microtubule-associated serine/threonine kinase. Mutations at this locus have been associated with autosomal dominant thrombocytopenia, also known as thrombocytopenia-2. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Feb 2010]

MASTL Products (7)

mRNA	Protein	Name
NM_001172303.3	NP_001165774.1	serine/threonine-protein kinase greatwall isoform 1
NM_001172304.3	NP_001165775.1	serine/threonine-protein kinase greatwall isoform 3
NM_001320756.2	NP_001307685.1	serine/threonine-protein kinase greatwall isoform 4
NM_001320757.2	NP_001307686.1	serine/threonine-protein kinase greatwall isoform 5
NM_001372029.1	NP_001358958.1	serine/threonine-protein kinase greatwall isoform 6
NM_001372030.1	NP_001358959.1	serine/threonine-protein kinase greatwall isoform 7
NM_032844.5	NP_116233.2	serine/threonine-protein kinase greatwall isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables kinase activity	IDA IDA: Inferred from direct assay	20818157	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	20538976	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in G2/M transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	20538976	GOA
involved in mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	20538976	GOA
involved in regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	20818157	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in centrosome	IDA IDA: Inferred from direct assay	20538976	GOA
located in cleavage furrow	IDA IDA: Inferred from direct assay	20538976	GOA
located in nucleus	IDA IDA: Inferred from direct assay	20538976	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MASTL Protein Structure

Pkinase

0
200
400
600
800
879 a.a.

Protein Preferred Names	Protein Names
serine/threonine-protein kinase greatwall	greatwall kinase homolog

MASTL Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P86892	GWL Antibody (YA6585)	WB, ICC/IF, IP	Human, Monkey

Related Diseases

Diseases	Alias
Autosomal Thrombocytopenia With Normal Platelets
Thrombocytopenia 2	THC2 Thrombocytopenia, Autosomal Dominant, 2 Thrombocytopenia Autosomal Dominant 2 Thrombocytopenia-2
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Gray Platelet Syndrome	Platelet Alpha-Granule Deficiency GPS Bdplt4 Bleeding Disorder, Platelet-Type, 4 Grey Platelet Syndrome Platelet-Type Bleeding Disorder 4 Marked Decrease Or Absence Of Alpha-Granules And Of Platelet-Specific Alpha-Granule Proteins Deficient Alpha Granule Syndrome Platelet Alpha Granule Deficiency Platelet Granule Defect Alpha Storage Pool Deficiency Bleeding Disorder Platelet-Type 4

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-137552	MKI-1	Inhibitor	98.13%	Unkown
HY-156716	MASTL-IN-2	Inhibitor	98.89%	Unkown
HY-156715	MASTL-IN-1	Inhibitor	99.54%	Unkown
HY-162732	MASTL-IN-4	Inhibitor	99.69%	Unkown
HY-W231513	MASTL/Aurora A-IN-1	Inhibitor	99.47%	Unkown
HY-185310	MKI-2	Inhibitor	/	Unkown
HY-162731	MASTL-IN-3	Inhibitor	98.86%	Unkown
HY-182391	MKI-3	Inhibitor	/	Unkown
HY-185310A	MKI-2 hydrochloride	Inhibitor	99.57%	Unkown
HY-E70743	MASTL Recombinant Human Active Protein Kinase		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MASTL	MGD	MGI:1914371
Canis familiaris	MASTL	VGNC	VGNC:43036
Rattus norvegicus	MASTL	RGD	RGD:1309186
Bos taurus	MASTL	VGNC	VGNC:31260
Macaca mulatta	MASTL	VGNC	VGNC:97789
Felis catus	MASTL	VGNC	VGNC:63395
Others	MASTL	NCBI