BCAS1 - brain enriched myelin associated protein 1 Gene

Also Known as AIBC1; NABC1; PMES-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8537

About BCAS1

Cytogenetic location: 20q13.2 Genomic coordinates (GRCh38): 20:53,943,541-54,070,594 (from NCBI)

This gene has 11 transcripts (splice variants) and 125 orthologues. Biased expression in stomach (RPKM 58.5), colon (RPKM 41.1) and 7 other tissues.

Summary

This gene resides in a region at 20q13 which is amplified in a variety of tumor types and associated with more aggressive tumor phenotypes. Among the genes identified from this region, it was found to be highly expressed in three amplified breast Cancer cell lines and in one breast tumor without amplification at 20q13.2. However, this gene is not in the common region of maximal amplification and its expression was not detected in the breast Cancer cell line MCF7, in which this region is highly amplified. Although not consistently expressed, this gene is a candidate oncogene. [provided by RefSeq, Apr 2016]

BCAS1 Products (7)

mRNA Protein Name
NM_001316361.3 NP_001303290.1 breast carcinoma-amplified sequence 1 isoform 2
NM_001323347.2 NP_001310276.1 breast carcinoma-amplified sequence 1 isoform 2
NM_001366295.2 NP_001353224.1 breast carcinoma-amplified sequence 1 isoform 3
NM_001366296.2 NP_001353225.1 breast carcinoma-amplified sequence 1 isoform 4
NM_001366297.2 NP_001353226.1 breast carcinoma-amplified sequence 1 isoform 5
NM_001366298.2 NP_001353227.1 breast carcinoma-amplified sequence 1 isoform 6
NM_003657.4 NP_003648.2 breast carcinoma-amplified sequence 1 isoform 1
Protein Preferred Names Protein Names

breast carcinoma-amplified sequence 1

  • amplified and overexpressed in breast cancer

BCAS1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P86253 NABC1 Antibody (YA5945) WB Human

Related Diseases

Diseases Alias
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-16993 OICR-9429 99.71% Unkown
HY-RS01399 BCAS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22405 Bcas1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28929 Bcas1 Rat Pre-designed siRNA Set A / Unkown
Bioactive MoleculesInhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991567 VX5 Modulator 96.19% Unkown
HY-P992476 TJX7 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus BCAS1 MGD MGI:1924210
Macaca mulatta BCAS1 VGNC VGNC:98871
Rattus norvegicus BCAS1 RGD RGD:628644
Felis catus BCAS1 VGNC VGNC:98869
Canis familiaris BCAS1 VGNC VGNC:98867
Bos taurus BCAS1 VGNC VGNC:98868
Others BCAS1 NCBI