CTSF - cathepsin F Gene

Also Known as CATSF; CLN13

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8722

About CTSF

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:66,563,464-66,568,606 (from NCBI)

This gene has 39 transcripts (splice variants), 541 orthologues, 12 paralogues and is associated with 2 phenotypes. Broad expression in ovary (RPKM 64.5), testis (RPKM 55.5) and 24 other tissues.

Summary

Cathepsins are papain family cysteine proteinases that represent a major component of the lysosomal proteolytic system. Cathepsins generally contain a signal sequence, followed by a propeptide and then a catalytically active mature region. The very long (251 amino acid residues) proregion of the Cathepsin F precursor contains a C-terminal domain similar to the pro-segment of Cathepsin L-like Enzymes, a 50-residue flexible linker peptide, and an N-terminal domain predicted to adopt a cystatin-like fold. The Cathepsin F proregion is unique within the papain family cysteine proteases in that it contains this additional N-terminal segment predicted to share structural similarities with cysteine Protease Inhibitors of the cystatin superfamily. This cystatin-like domain contains some of the elements known to be important for inhibitory activity. CTSF encodes a predicted protein of 484 Amino acids which contains a 19 residue signal peptide. Cathepsin F contains five potential N-glycosylation sites, and it may be targeted to the endosomal/lysosomal compartment via the mannose 6-phosphate receptor pathway. The Cathepsin F gene is ubiquitously expressed, and it maps to chromosome 11q13, close to the gene encoding Cathepsin W. [provided by RefSeq, Jul 2008]

CTSF Products (1)

mRNA	Protein	Name
NM_003793.4	NP_003784.2	cathepsin F precursor

CTSF Protein Structure

Inhibitor_I29

Peptidase_C1

0
100
200
300
400
484 a.a.

Protein Preferred Names	Protein Names
cathepsin F

Recombinant CTSF Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71701	CTSF Protein, Human (His)	Q9UBX1 (P273-D484)	≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Ceroid Lipofuscinosis, Neuronal, 13	Neuronal Ceroid Lipofuscinosis 13 CLN13 Neuronal Ceroid Lipofuscinosis 13 Kufs Type Cln13 Disease Lipofuscinosis, Ceroid, Neuronal, Type 13
Neuronal Ceroid Lipofuscinosis	Hereditary Ceroid Lipofuscinosis Batten Disease Ncl Neuronal Ceroid-Lipofuscinoses Lipofuscinosis, Ceroid, Neuronal Juvenile Neuronal Ceroid Lipofuscinosis Cerebromacular Dystrophy Cerebromacular Degeneration Ceroid-Lipofuscinosis Ncl - [Neuronal Ceroid Lipofuscinosis] Amaurotic Familial Idiocy Amaurotic Idiocy Amaurotic Idiot Neuronal Lipofuscinosis Pigmentary Retinal Lipoid Neuronal Heredodegeneration
Ceroid Lipofuscinosis, Neuronal, 10	Neuronal Ceroid Lipofuscinosis Due To Cathepsin D Deficiency Neuronal Ceroid Lipofuscinosis 10 CLN10 Cathepsin D Deficiency Congenital Neuronal Ceroid Lipofuscinosis Neuronal Ceroid Lipofuscinosis Cathepsin D-Deficient Cln10 Disease Ceroid Lipofuscinosis, Neuronal, Cathepsin D-Deficient Cln10 Disease, Adult Cln10 Disease, Congenital Cln10 Disease, Juvenile Cln10 Disease, Late Infantile Ceroid Lipofuscinosis Neuronal Cathepsin D-Deficient Cathepsin D Deficient Neuronal Ceroid Lipofuscinosis Congenital Ncl Lipofuscinosis, Ceroid, Neuronal, Type 10 Neuronal Ceroid Lipofuscinosis, Congenital
Ceroid Lipofuscinosis, Neuronal, 11	Neuronal Ceroid Lipofuscinosis 11 CLN11 Cln11 Disease Grn-Related Neuronal Ceroid-Lipofuscinosis Lipofuscinosis, Ceroid, Neuronal, Type 11
Spinocerebellar Ataxia, Autosomal Recessive 7	SCAR7 Autosomal Recessive Spinocerebellar Ataxia 7 Spinocerebellar Ataxia Autosomal Recessive 7 Childhood Onset Autosomal Recessive Slowly Progressive Spinocerebellar Ataxia Childhood-Onset Autosomal Recessive Slowly Progressive Spinocerebellar Ataxia Autosomal Recessive Spinocerebellar Ataxia Type 7 Spinocerebellar Ataxia, Autosomal Recessive, 7 Ataxia, Spinocerebellar, Autosomal Recessive, Type 7
Clonorchiasis	Oriental Liver Fluke Disease Clonorchis Liver Infection Clonorchiosis Chinese Liver Fluke Disease Hepatic Distomiasis Due To Clonorchis Sinensis Infection Due To Clonorchis Sinensis Hepatic Distomiasis Hepatic Distomatosis Chinese Liver Fluke Disorder Oriental Liver Fluke Disorder Clonorchis Infestation Chinese Liver Fluke Infestation Liver Fluke Disease Due To Clonorchis Sinensis Oriental Liver Fluke Infestation
Progressive Myoclonus Epilepsy 3	Cln14 Disease Epm3 Neuronal Ceroid Lipofuscinosis 14 Pme Type 3 Progressive Myoclonic Epilepsy Due To Kctd7 Deficiency Progressive Myoclonus Epilepsy Type 3 Epilepsy, Progressive Myoclonic 3
Keratopathy
Paragonimiasis	Infection By Paragonimus Lung Fluke Disease Lung Fluke Infection Pulmonary Paragonimiasis Paragonimus Westermani Infection Pulmonary Distomiasis Parasitic Haemoptysis Oriental Lung Fluke Disease Endemic Haemoptysis Paragonimosis Pulmonary Distomatosis Lung Fluke Disorder Infestation By Paragonimus Infection Due To Paragonimus Species Infestation Due To Paragonimus Species Oriental Lung Fluke Infestation Endemic Oriental Haemoptysis
Ceroid Lipofuscinosis, Neuronal, 3	Batten Disease Juvenile Neuronal Ceroid Lipofuscinosis Neuronal Ceroid Lipofuscinosis 3 CLN3 Jncl Spielmeyer-Vogt Disease Vogt-Spielmeyer Disease Spielmeyer-Sjogren Disease Cln3 Disease Neuronal Ceroid Lipofuscinosis, Juvenile Cln3 Disease, Juvenile Spielmeyer Sjogren Disease Vogt Spielmeyer Disease Batten-Mayou Disease Batten-Spielmeyer-Vogt Disease Cln3-Related Neuronal Ceroid-Lipofuscinosis Juvenile Batten Disease Juvenile Cerebroretinal Degeneration Classic Juvenile Ncl Classic Juvenile Neuronal Ceroid Lipofuscinosis Juvenile Ncl Lipofuscinosis, Ceroid, Neuronal, Type 3
Opisthorchiasis	Infection By Opisthorchis Infection Due To Opisthorchis Infection Due To Cat Liver Fluke Infection By Cat Liver Fluke Opisthorchiosis Cat Liver Fluke Fever Cat Liver Fluke Disease Opisthorchis Infestation Cat Liver Fluke Infestation
Spastic Paraplegia 48, Autosomal Recessive	SPG48 Hereditary Spastic Paraplegia 48 Autosomal Recessive Spastic Paraplegia Type 48 Autosomal Recessive Spastic Paraplegia 48 Paraplegia, Spastic, Type 48, Autosomal Recessive
Galactosialidosis	Goldberg Syndrome Neuraminidase Deficiency With Beta-Galactosidase Deficiency Ppca Deficiency GSL Lysosomal Protective Protein Deficiency Cathepsin A Deficiency Neuraminidase/Beta-Galactosidase Expression Protective Protein/Cathepsin A Deficiency Ngbe Cathepsin A Deficiency Of Lysosomal Protective Protein Deficiency Of Deficiency Of Cathepsin A Neuraminidase Beta-Galactosidase Deficiency Protective Protein Cathepsin A Deficiency
Progressive Myoclonus Epilepsy	Pme Progressive Myoclonic Epilepsy Myoclonic Epilepsies, Progressive Unverricht-Lundborg Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03334	CTSF Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22132	Ctsf Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28654	Ctsf Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CTSF	MGD	MGI:1861434
Bos taurus	CTSF	VGNC	VGNC:27815
Macaca mulatta	CTSF	VGNC	VGNC:71555
Rattus norvegicus	CTSF	RGD	RGD:1308181
Canis familiaris	CTSF	VGNC	VGNC:39711
Felis catus	CTSF	VGNC	VGNC:82005
Others	CTSF	NCBI