RNGTT - RNA guanylyltransferase and 5'-phosphatase Gene

Also Known as HCE; HCE1; hCAP; CAP1A

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8732

About RNGTT

Cytogenetic location: 6q15 Genomic coordinates (GRCh38): 6:88,609,897-88,963,618 (from NCBI)

This gene has 4 transcripts (splice variants), 207 orthologues and 1 paralogue. Ubiquitous expression in lymph node (RPKM 8.1), testis (RPKM 5.3) and 24 other tissues.

Summary

Enables mRNA guanylyltransferase activity and triphosphatase activity. Involved in 7-methylguanosine mRNA capping. Predicted to be located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

RNGTT Products (3)

mRNA Protein Name
NM_001286426.2 NP_001273355.1 mRNA-capping enzyme isoform b
NM_001286428.2 NP_001273357.1 mRNA-capping enzyme isoform c
NM_003800.5 NP_003791.3 mRNA-capping enzyme isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables RNA guanylyltransferase activity IDA
IDA: Inferred from direct assay
21636784 GOA
enables inorganic triphosphate phosphatase activity IDA
IDA: Inferred from direct assay
9473487 GOA
enables mRNA guanylyltransferase activity IDA
IDA: Inferred from direct assay
9473487 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25137142 GOA
Biological Process GO Annotation Evidence References Source
involved in 7-methylguanosine mRNA capping IDA
IDA: Inferred from direct assay
9473487 GOA
involved in RNA processing IDA
IDA: Inferred from direct assay
21636784 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RNGTT Protein Structure

DSPc

DSPc: Dual specificity phosphatase, catalytic domain (61 - 172)

mRNA_cap_enzyme

mRNA_cap_enzyme: mRNA capping enzyme, catalytic domain (272 - 460)

mRNA_cap_C

mRNA_cap_C: mRNA capping enzyme, C-terminal domain (464 - 560)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 597 a.a.
Protein Preferred Names Protein Names

mRNA-capping enzyme

  • HCAP1

RNGTT Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RNGTT O60942 APPBP2 Homo sapiens Q92624
Validated Y2H
32296183
Intra
RNGTT O60942 APPBP2 Homo sapiens Q92624
Y2H Array
32296183
Intra
RNGTT O60942 APPBP2 Homo sapiens Q92624
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

RNGTT Antibodies

Cat. No. Product Name Application Reactivity
HY-P83214 HCE Antibody (YA2959) WB, ICC/IF, IP Human, Rat
HY-P83214A HCE Antibody (YA2959)(PBS only) WB, ICC/IF, IP Human, Rat

Related Diseases

Diseases Alias
Cecum Carcinoma

  • Cecum Cancer

  • Caecum Carcinoma

  • Carcinoma Of Cecum

  • Cecal Cancer

  • Malignant Neoplasm Of Caecum

  • Malignant Tumor Of The Cecum
Cecum Adenocarcinoma

  • Cecal Adenocarcinoma

  • Adenocarcinoma Of Cecum
Photokeratitis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12099 RNGTT Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta RNGTT VGNC VGNC:76709
Felis catus RNGTT VGNC VGNC:102508
Rattus norvegicus RNGTT RGD RGD:1311410
Bos taurus RNGTT VGNC VGNC:34076
Canis familiaris RNGTT VGNC VGNC:45679
Mus musculus RNGTT MGD MGI:1329041