MGAM - maltase-glucoamylase Gene
Also Known as MG; MGA
Species: Homo sapiens
About MGAM
This gene has 9 transcripts (splice variants), 1 gene allele, 315 orthologues and 6 paralogues. Biased expression in small intestine (RPKM 57.9), duodenum (RPKM 42.9) and 2 other tissues.
Summary
This gene encodes maltase-glucoamylase, which is a brush border membrane enzyme that plays a role in the final steps of digestion of starch. The protein has two catalytic sites identical to those of sucrase-isomaltase, but the proteins are only 59% homologous. Both are members of glycosyl hydrolase family 31, which has a variety of substrate specificities. [provided by RefSeq, Jul 2008]
MGAM Products (2)
| mRNA | Protein | Name |
|---|---|---|
| NM_001365693.1 | NP_001352622.1 | maltase-glucoamylase isoform 1 |
| NM_004668.3 | NP_004659.2 | maltase-glucoamylase isoform 2 |
| Molecular Function GO Annotation | Evidence | Verweise | Source |
|---|---|---|---|
| enables alpha-1,4-glucosidase activity |
IDA
IDA: Inferred from direct assay
|
18036614 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
32296183 | GOA |
| Biological Process GO Annotation | Evidence | Verweise | Source |
|---|---|---|---|
| involved in dextrin catabolic process |
IDA
IDA: Inferred from direct assay
|
18036614 | GOA |
| involved in maltose catabolic process |
IDA
IDA: Inferred from direct assay
|
18036614 | GOA |
| Cellular Component GO Annotation | Evidence | Verweise | Source |
|---|---|---|---|
| located in apical plasma membrane |
IDA
IDA: Inferred from direct assay
|
3143729 | GOA |
MGAM Protein Structure
Trefoil: Trefoil (P-type) domain (89 - 132)
Glyco_hydro_31: Glycosyl hydrolases family 31 (349 - 821)
Trefoil: Trefoil (P-type) domain (960 - 998)
Glyco_hydro_31: Glycosyl hydrolases family 31 (1215 - 1717)
- 0
- 300
- 600
- 900
- 1200
- 1500
- 1857 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
maltase-glucoamylase |
|
MGAM Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | Verweise |
|---|---|---|---|---|---|---|---|
|
Intra
|
MGAM | O43451 | AQP6 | Homo sapiens | Q13520 | 32296183 | |
|
Intra
|
MGAM | O43451 | AQP6 | Homo sapiens | Q13520 | 32296183 | |
|
Intra
|
MGAM | O43451 | AQP6 | Homo sapiens | Q13520 | 32296183 | |
|
Intra
|
MGAM | O43451 | SLC18A1 | Homo sapiens | P54219-3 | 32296183 | |
|
Intra
|
MGAM | O43451 | SLC18A1 | Homo sapiens | P54219-3 | 32296183 | |
|
Intra
|
MGAM | O43451 | SLC18A1 | Homo sapiens | P54219-3 | 32296183 | |
|
Intra
|
MGAM | O43451 | CPLX4 | Homo sapiens | Q7Z7G2 | 32296183 | |
|
Intra
|
MGAM | O43451 | CPLX4 | Homo sapiens | Q7Z7G2 | 32296183 | |
|
Intra
|
MGAM | O43451 | CPLX4 | Homo sapiens | Q7Z7G2 | 32296183 | |
|
Intra
|
MGAM | O43451 | GPR42 | Homo sapiens | O15529 | 32296183 | |
|
Intra
|
MGAM | O43451 | GPR42 | Homo sapiens | O15529 | 32296183 | |
|
Intra
|
MGAM | O43451 | CREB3L1 | Homo sapiens | Q96BA8 | 32296183 | |
|
Intra
|
MGAM | O43451 | CREB3L1 | Homo sapiens | Q96BA8 | 32296183 | |
|
Intra
|
MGAM | O43451 | CREB3L1 | Homo sapiens | Q96BA8 | 32296183 | |
|
Intra
|
MGAM | O43451 | TMEM14B | Homo sapiens | Q9NUH8 | 32296183 | |
|
Intra
|
MGAM | O43451 | TMEM14B | Homo sapiens | Q9NUH8 | 32296183 | |
|
Intra
|
MGAM | O43451 | TMEM14B | Homo sapiens | Q9NUH8 | 32296183 |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Intestinal Disaccharidase Deficiency |
|
|
| Glycogen Storage Disease Ii |
|
|
| Diarrhea |
|
|
| Pneumatosis Cystoides Intestinalis |
|
|
| Sucrase-Isomaltase Deficiency, Congenital |
|
|
| Glycogen Storage Disease |
|
|
| Residual Stage Of Open Angle Glaucoma |
|
|
| Protein-Energy Malnutrition |
|
|
| Hirata Disease |
|
|
| Scheie Syndrome |
|
|
| Postgastrectomy Syndrome |
|
|
| Hypoglycemic Coma |
|
|
| Lactase Deficiency, Congenital |
|
|
| Colon Adenocarcinoma |
|
|
| Glycogen Storage Disease Iii |
|
|
| Danon Disease |
|
|
| Diabetes Mellitus, Ketosis-Prone |
|
|
| Diabetic Autonomic Neuropathy |
|
|
| Nutritional Deficiency Disease |
|
|
| Functional Gastric Disease |
|
|
| Sphingolipidosis |
|
|
| Dysentery |
|
|
| Diabetes Mellitus |
|
|
| Mucopolysaccharidosis, Type Ii |
|
|
| Gaucher'S Disease |
|
|
| Acute Laryngopharyngitis |
|
|
| Parkinson Disease 17 |
|
|
| Myoclonic Epilepsy Of Lafora |
|
|
| Carbohydrate Metabolic Disorder |
|
|
| Mucopolysaccharidosis Iii |
|
|
| Barre-Lieou Syndrome |
|
|
| Lipid Metabolism Disorder |
|
|
| Hypertension, Essential |
|
|
| Hypertrophic Cardiomyopathy |
|
|
| Myopathy |
|
|
| Neuromuscular Disease |
|
|
| Type 2 Diabetes Mellitus |
|
|
| Peripheral Nervous System Disease |
|
|
| Body Mass Index Quantitative Trait Locus 11 |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Rattus norvegicus | MGAM | RGD | RGD:9369725 |
| Mus musculus | MGAM | MGD | MGI:1203495 |
| Felis catus | MGAM | VGNC | VGNC:68246 |
| Canis familiaris | MGAM | VGNC | VGNC:43211 |
| Macaca mulatta | MGAM | VGNC | VGNC:74713 |
| Bos taurus | MGAM | VGNC | VGNC:31446 |
| Others | MGAM | NCBI |