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UBE2M - ubiquitin conjugating enzyme E2 M Gene

Also Known as UBC12; hUbc12; UBC-RS2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9040

About UBE2M

Cytogenetic location: 19q13.43 Genomic coordinates (GRCh38): 19:58,555,712-58,558,611 (from NCBI)

This gene has 5 transcripts (splice variants) and 124 orthologues. Ubiquitous expression in brain (RPKM 24.7), testis (RPKM 23.2) and 25 other tissues.

Summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating Enzymes, or E1s, ubiquitin-conjugating Enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is linked with a ubiquitin-like protein, NEDD8, which can be conjugated to cellular proteins, such as Cdc53/culin. [provided by RefSeq, Jul 2008]

UBE2M Products (1)

mRNA	Protein	Name
NM_003969.4	NP_003960.1	NEDD8-conjugating enzyme Ubc12

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables NEDD8 transferase activity	IDA IDA: Inferred from direct assay	19250909	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15361859	GOA
enables ubiquitin-protein transferase activity	IMP IMP: Inferred from mutant phenotype	15694336	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in protein modification process	IMP IMP: Inferred from mutant phenotype	15694336	GOA
involved in protein neddylation	IDA IDA: Inferred from direct assay	19250909	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBE2M Protein Structure

UQ_con

0
100
183 a.a.

Protein Preferred Names	Protein Names
NEDD8-conjugating enzyme Ubc12	NEDD8 carrier protein

UBE2M Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	UBE2M	P61081	PRKN	Homo sapiens	O60260-5	Validated Y2H	32814053
Intra	UBE2M	P61081	PRKN	Homo sapiens	O60260-5	Y2H Array	32814053
Intra	UBE2M	P61081	PRKN	Homo sapiens	O60260-5	Y2H Pooling	32814053
Intra	UBE2M	P61081	GNB2	Homo sapiens	P62879	Validated Y2H	32814053
Intra	UBE2M	P61081	GNB2	Homo sapiens	P62879	Y2H Pooling	32814053
Intra	UBE2M	P61081	GNB2	Homo sapiens	P62879	Y2H Array	32814053
Intra	UBE2M	P61081	CUL1	Homo sapiens	Q13616	Enzymatic Study	18805092
Intra	UBE2M	P61081	RBX1	Homo sapiens	P62877	Validated Y2H	32296183
Intra	UBE2M	P61081	RBX1	Homo sapiens	P62877	Enzymatic Study	18805092
Intra	UBE2M	P61081	RBX1	Homo sapiens	P62877	Y2H	19549727
Intra	UBE2M	P61081	NEDD8	Homo sapiens	Q15843	Comigration in SDS	18264111
Intra	UBE2M	P61081	NEDD8	Homo sapiens	Q15843	Anti Bait CoIP	17353931
Intra	UBE2M	P61081	NEDD8	Homo sapiens	Q15843	Pull Down	19713960
Intra	UBE2M	P61081	NEDD8	Homo sapiens	Q15843	Anti Tag CoIP	35271311
Intra	UBE2M	P61081	NEDD8	Homo sapiens	Q15843	Enzymatic Study	17098746
Intra	UBE2M	P61081	NEDD8	Homo sapiens	Q15843	Anti Tag CoIP	33961781
Intra	UBE2M	P61081	NEDD8	Homo sapiens	Q15843	Anti Tag CoIP	28514442
Intra	UBE2M	P61081	NEDD8	Homo sapiens	Q15843	MAPPIT	25416956
Intra	UBE2M	P61081	UBA3	Homo sapiens	Q8TBC4	Anti Tag CoIP	35271311
Intra	UBE2M	P61081	UBA3	Homo sapiens	Q8TBC4	Anti Bait CoIP	17353931
Intra	UBE2M	P61081	UBA3	Homo sapiens	Q8TBC4	Enzymatic Study	18805092
Intra	UBE2M	P61081	UBA3	Homo sapiens	Q8TBC4	Enzymatic Study	17098746
Intra	UBE2M	P61081	UBA3	Homo sapiens	Q8TBC4	X-Ray Diffraction	15694336
Intra	UBE2M	P61081	UBA3	Homo sapiens	Q8TBC4	Anti Tag CoIP	33961781
Intra	UBE2M	P61081	UBA3	Homo sapiens	Q8TBC4	Y2H	19549727
Intra	UBE2M	P61081	DCUN1D1	Homo sapiens	Q96GG9	Anti Tag CoIP	33961781
Intra	UBE2M	P61081	DCUN1D1	Homo sapiens	Q96GG9	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant UBE2M Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71406	UBE2M Protein, Human	P61081 (M1-K183)	≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-111505	NAcM-OPT	Inhibitor	98.69%	Unkown
HY-RS15355	UBE2M Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19492	Ube2m Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25986	Ube2m Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	UBE2M	VGNC	VGNC:36589
Mus musculus	UBE2M	MGD	MGI:108278
Felis catus	UBE2M	VGNC	VGNC:66762
Rattus norvegicus	UBE2M	RGD	RGD:1307614
Canis familiaris	UBE2M	VGNC	VGNC:48059
Others	UBE2M	NCBI