2. Gene
  3. UBE2M - ubiquitin conjugating enzyme E2 M Gene

UBE2M - ubiquitin conjugating enzyme E2 M Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as UBC12; hUbc12; UBC-RS2

Gene ID: 9040 | Gene type: protein coding

About UBE2M

Cytogenetic location: 19q13.43 Genomic coordinates (GRCh38): 19:58,555,712-58,558,611 (from NCBI)

This gene has 5 transcripts (splice variants) and 124 orthologues. Ubiquitous expression in brain (RPKM 24.7), testis (RPKM 23.2) and 25 other tissues.

Summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating Enzyme family. The encoded protein is linked with a ubiquitin-like protein, NEDD8, which can be conjugated to cellular proteins, such as Cdc53/culin. [provided by RefSeq, Jul 2008]

UBE2M Products(1)

mRNA Protein Name
NM_003969.4 NP_003960.1 NEDD8-conjugating enzyme Ubc12

UBE2M Protein Structure

UQ_con

UQ_con: Ubiquitin-conjugating enzyme (33 - 167)

  • 0
  • 100
  • 183 a.a.
Protein Preferred Names Protein Names

NEDD8-conjugating enzyme Ubc12

NEDD8 carrier protein

Recombinant UBE2M Proteins

Cat. No. Product Name Accession Purity
HY-P71406 UBE2M Protein, Human P61081 (M1-K183) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-111505 NAcM-OPT Inhibitor 99.81% Unkown
HY-RS15355 UBE2M Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus UBE2M VGNC VGNC:36589
Mus musculus UBE2M MGD MGI:108278
Felis catus UBE2M VGNC VGNC:66762
Rattus norvegicus UBE2M RGD RGD:1307614
Canis familiaris UBE2M VGNC VGNC:48059
Others UBE2M NCBI