SLFN11 - schlafen family member 11 Gene

Also Known as SLFN8/9

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 91607

About SLFN11

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:35,350,305-35,373,621 (from NCBI)

This gene has 14 transcripts (splice variants), 108 orthologues and 6 paralogues. Ubiquitous expression in lung (RPKM 14.8), thyroid (RPKM 12.0) and 24 other tissues.

Summary

Enables tRNA binding activity. Involved in several processes, including defense response to virus; negative regulation of G1/S transition of mitotic cell cycle; and replication fork arrest. Located in cytosol; nucleoplasm; and site of DNA damage. [provided by Alliance of Genome Resources, Apr 2022]

SLFN11 Products (16)

mRNA Protein Name
NM_001104587.2 NP_001098057.1 schlafen family member 11
NM_001104588.2 NP_001098058.1 schlafen family member 11
NM_001104589.2 NP_001098059.1 schlafen family member 11
NM_001104590.2 NP_001098060.1 schlafen family member 11
NM_001376007.1 NP_001362936.1 schlafen family member 11
NM_001376008.1 NP_001362937.1 schlafen family member 11
NM_001376009.1 NP_001362938.1 schlafen family member 11
NM_001376010.1 NP_001362939.1 schlafen family member 11
NM_001376011.1 NP_001362940.1 schlafen family member 11
NM_001387158.1 NP_001374087.1 schlafen family member 11
NM_001387159.1 NP_001374088.1 schlafen family member 11
NM_001387160.1 NP_001374089.1 schlafen family member 11
NM_001387161.1 NP_001374090.1 schlafen family member 11
NM_001387162.1 NP_001374091.1 schlafen family member 11
NM_001387163.1 NP_001374092.1 schlafen family member 11
NM_152270.4 NP_689483.3 schlafen family member 11

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP hydrolysis activity IDA
IDA: Inferred from direct assay
29395061 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
29395061 GOA
enables tRNA binding IDA
IDA: Inferred from direct assay
23000900 GOA
Biological Process GO Annotation Evidence References Source
involved in DNA damage response IDA
IDA: Inferred from direct assay
29395061 GOA
involved in chromatin remodeling IDA
IDA: Inferred from direct assay
29395061 GOA
involved in defense response to virus IMP
IMP: Inferred from mutant phenotype
23000900 GOA
involved in negative regulation of DNA replication IDA
IDA: Inferred from direct assay
29395061 GOA
involved in negative regulation of G1/S transition of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
22927417 GOA
involved in replication fork arrest IDA
IDA: Inferred from direct assay
29395061 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
22927417 GOA
located in site of DNA damage IDA
IDA: Inferred from direct assay
29395061 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLFN11 Protein Structure

AlbA_2

AlbA_2: Putative DNA-binding domain (209 - 324)

DUF2075

DUF2075: Uncharacterized conserved protein (DUF2075) (595 - 679)

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  • 901 a.a.
Protein Preferred Names Protein Names

schlafen family member 11

SLFN11 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83769 SLFN11 Antibody WB Human

Related Diseases

Diseases Alias
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13363 SLFN11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990947 Tilatamig Inhibitor 99.99% Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SLFN11 RGD RGD:1359139
Others SLFN11 NCBI